Admin: Mechanical determinants of organ-selective metastatic colonization, dormancy and outgrowth

管理核心：摘要 我们建议组建一个由五位转移性癌症负责人组成的无与伦比的团队 研究涉及五个机构(麻省理工学院、宾夕法尼亚大学、西北大学、麻省理工学院安德森医学中心 得克萨斯大学和哈佛大学达纳·法伯癌症研究所)。拟建的MetNet中心 行政核心将由MPI共同教授罗杰·卡姆领导。这笔赠款的日常管理将是 由位于麻省理工学院的中心管理员管理，负责维护所有相关记录 并将建立和监督与附属机构之间的协议。此外，居中 行政部门将由一名数据管理员提供支持，他将在哈佛大学的博士的共同指导下工作。 弗朗齐斯卡·米歇尔。数据管理员将担任MetNet资源和数据共享工作组成员，并 将负责(与中心管理员合作)共同开发MetNet Center的 网站，关于标准元数据字段的讨论，确定是否将预先发布数据 跨MetNet共享，与不同的NCI癌症联合创建MetNet数据上传的SOP 研究数据共享，并领导有关数据质量控制、交叉验证和 再现性。将成立一个外部咨询委员会(EAC)，将调查人员与 在癌症转移和肿瘤微环境相关领域的专业知识。选管会被设想为一个 一组高度活跃的成员，致力于向MetNet中心领导层提供科学方向和 审查进展评估、研究战略和实施、领导和传播，所有这些都在 努力最大限度地发挥中心的影响力。MetNet中心将提高翻译价值和潜力 通过聘请患者代言人来影响其研究，该患者代言人将作为EAC的审查员和 试点项目赠款申请的评估员，并将被邀请参加每月的研究网络研讨会和 参加季度联合MPI会议和年度现场访问。促进协作和进一步支持 多机构沟通，广泛传播知识，并提供MetNet中心 学员提高技术和专业发展技能的机会，行政核心 将支持虚拟的月度研讨会系列，并将提供MetNet中心内部的研究交流和50,000美元 试点。在目标1中，行政核心将监督和协调项目任务，建立 多学科项目监督，并通过视频会议和面对面建立时间表里程碑 开会。在目标2中，我们将制定、协调、安排和评估研究会议、研究座谈会、 以及来访科学家的项目，这些项目对我们的研究任务和传播至关重要。在《目标3》中，我们将 创建MetNet Center的网站：促进项目成果的沟通；充当访问渠道 外部研究人员的询问点；作为面向公众的可访问研究结果的来源 通知乳腺癌患者社区；并作为所有中心的中央和可访问的存储库 生成的协议。

Administrative Core: SUMMARY We propose to bring together an unparalleled team comprised of five leaders in metastatic cancer research across five institutions (MIT, University of Pennsylvania, Northwestern University, MD Anderson at The University of Texas, and the Dana Farber Cancer Institute at Harvard University). The proposed MetNet Center Administrative Core will be led by co-MPI Prof. Roger Kamm. The day-to-day administration of this grant will be managed by the Center Administrator, located at MIT, who will be responsible for maintaining all records relative to this award and will establish and monitor agreements with affiliated institutions. Additionally, center administration will be supported by a Data Manager, who will be located at Harvard under the co-direction of Dr. Franziska Michor. The Data Manager will sit on the Resource and Data Sharing Working Group of MetNet and will be responsible for the co-development (in collaboration with the Center Administrator) of the MetNet Center’s website, discussions regarding standard metadata fields, determine whether there will be pre-publication of data sharing across the MetNet, create SOPs for MetNet data upload in conjunction with the different NCI Cancer Research Data Commons, and lead the conversations about data quality control, cross validation, and reproducibility. An External Advisory Committee (EAC) will be formed, bringing together investigators with expertise in fields related to cancer metastasis and the tumor microenvironment. The EAC is envisioned as a group of highly active members engaged to advise the MetNet Center leadership on scientific direction and review progress evaluation, research strategies and implementation, leadership and dissemination, all in the effort to maximize the impact of the center. The MetNet center will enhance the translational value and potential impact of its research by engaging a Patient Advocate, who will be a member of the EAC as a reviewer and evaluator of the pilot project grant applications, and will be invited to attend the monthly research webinars and participate in the quarterly Co-MPI meetings, and the Annual Site Visit. To foster collaboration and further support multi-institutional communication, wide reaching knowledge dissemination, and provide the MetNet Center trainees opportunities for enhancing their technical and professional development skills, the Administrative Core will support a virtual, monthly seminar series, and will offer intra-MetNet Center research exchanges and $50,000 pilot projects. In Aim 1 the Administrative Core will oversee and coordinate the project mission, establish multidisciplinary project oversight and establish timeline milestones with videoconferencing and face-to-face meetings. In Aim 2, we will develop, coordinate, schedule, and evaluate research meetings, research symposia, and the visiting scientists’ programs that are critical to our research mission and dissemination. In Aim 3, we will create the MetNet Center’s website to: facilitate communication on program achievements; act as the access point for enquiries from external researchers; serve as publicly-facing source of accessible research results to inform the breast cancer patient community; and serve as a central and accessible repository for all Center generated protocols.