Admin: Mechanical determinants of organ-selective metastatic colonization, dormancy and outgrowth

管理员：器官选择性转移定植、休眠和生长的机械决定因素

• 批准号: 10688245
• 负责人: ROGER D KAMM
• 金额: $ 18.93万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10688245
• 关键词: Achievement; Address; Administrator; Advisory Committees; Advocate; Agreement; Applications Grants; Award; Biochemical; Breast Cancer Patient; Cells; Cessation of life; Chromatin; Chromatin Structure; Circulation; Clinical Data; Collaborations; Communication; Communities; Computer Models; Dana-Farber Cancer Institute; Data; Data Commons; Data Set; Development; Disease; Disease Progression; Disseminated Malignant Neoplasm; Ensure; Environment; Evaluation; Exposure to; Fostering; Gene Expression Profile; Grant; In Vitro; Institution; Intervention; Knowledge; Lead; Leadership; Malignant Neoplasms; Mechanics; Mission; Modeling; Molecular; Monitor; Neoplasm Circulating Cells; Neoplasm Metastasis; Organ; Pathology; Patients; Pennsylvania; Phenotype; Pilot Projects; Program Reviews; Proliferating; Protocols documentation; Publications; Quality Control; Records; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Resource Sharing; Schedule; Scientist; Series; Signal Transduction; Site Visit; Source; Stress; Stromal Cells; Structure; Technology; Texas; Tissues; Universities; Validation; Videoconferencing; Visit; anticancer research; data quality; data sharing; high resolution imaging; in silico; in vivo; meetings; member; metadata standards; multidisciplinary; neoplastic cell; programs; repository; research data dissemination; response; skill acquisition; stressor; symposium; timeline; transcriptome; transcriptomics; tumor microenvironment; virtual; web site; webinar; working group

Administrative Core: SUMMARY We propose to bring together an unparalleled team comprised of five leaders in metastatic cancer research across five institutions (MIT, University of Pennsylvania, Northwestern University, MD Anderson at The University of Texas, and the Dana Farber Cancer Institute at Harvard University). The proposed MetNet Center Administrative Core will be led by co-MPI Prof. Roger Kamm. The day-to-day administration of this grant will be managed by the Center Administrator, located at MIT, who will be responsible for maintaining all records relative to this award and will establish and monitor agreements with affiliated institutions. Additionally, center administration will be supported by a Data Manager, who will be located at Harvard under the co-direction of Dr. Franziska Michor. The Data Manager will sit on the Resource and Data Sharing Working Group of MetNet and will be responsible for the co-development (in collaboration with the Center Administrator) of the MetNet Center’s website, discussions regarding standard metadata fields, determine whether there will be pre-publication of data sharing across the MetNet, create SOPs for MetNet data upload in conjunction with the different NCI Cancer Research Data Commons, and lead the conversations about data quality control, cross validation, and reproducibility. An External Advisory Committee (EAC) will be formed, bringing together investigators with expertise in fields related to cancer metastasis and the tumor microenvironment. The EAC is envisioned as a group of highly active members engaged to advise the MetNet Center leadership on scientific direction and review progress evaluation, research strategies and implementation, leadership and dissemination, all in the effort to maximize the impact of the center. The MetNet center will enhance the translational value and potential impact of its research by engaging a Patient Advocate, who will be a member of the EAC as a reviewer and evaluator of the pilot project grant applications, and will be invited to attend the monthly research webinars and participate in the quarterly Co-MPI meetings, and the Annual Site Visit. To foster collaboration and further support multi-institutional communication, wide reaching knowledge dissemination, and provide the MetNet Center trainees opportunities for enhancing their technical and professional development skills, the Administrative Core will support a virtual, monthly seminar series, and will offer intra-MetNet Center research exchanges and $50,000 pilot projects. In Aim 1 the Administrative Core will oversee and coordinate the project mission, establish multidisciplinary project oversight and establish timeline milestones with videoconferencing and face-to-face meetings. In Aim 2, we will develop, coordinate, schedule, and evaluate research meetings, research symposia, and the visiting scientists’ programs that are critical to our research mission and dissemination. In Aim 3, we will create the MetNet Center’s website to: facilitate communication on program achievements; act as the access point for enquiries from external researchers; serve as publicly-facing source of accessible research results to inform the breast cancer patient community; and serve as a central and accessible repository for all Center generated protocols.

行政核心：摘要 我们提议组建一个无与伦比的团队，由五位转移性癌症领域的领导人组成 研究横跨五个机构（麻省理工学院，宾夕法尼亚大学，西北大学，医学博士安德森在 德克萨斯大学和哈佛大学Dana Farber癌症研究所）。MetNet中心 行政核心将由共同MPI教授罗杰卡姆领导。这笔赠款的日常管理将 由位于麻省理工学院的中心管理员管理，他将负责维护所有相关记录 并将建立和监测与附属机构的协议。此外，中心 管理将由一名数据经理提供支持，该经理将在哈佛的Dr. 弗兰兹斯卡·米克尔数据经理将参加MetNet的资源和数据共享工作组， 将负责MetNet中心的共同开发（与中心管理员合作） 网站，关于标准元数据字段的讨论，确定是否将预先公布数据 在整个MetNet中共享，与不同的NCI Cancer一起创建MetNet数据上传的SOP 研究数据共享，并领导有关数据质量控制，交叉验证和 再现性将成立一个外部咨询委员会，将调查人员与 在癌症转移和肿瘤微环境相关领域的专业知识。选管会的设想是， 一组高度活跃的成员，致力于为MetNet中心领导层提供科学方向方面的建议， 审查进展评估、研究战略和执行、领导和传播，所有这些都在联合国系统内进行。 努力使中心的影响最大化。MetNet中心将提高翻译价值和潜力 通过聘请一名患者倡导者来影响其研究，该患者倡导者将作为EAC的成员担任评审员， 试点项目赠款申请的评估员，并将应邀参加每月的研究网络研讨会， 参加季度Co-MPI会议和年度现场访问。促进合作和进一步支持 多机构沟通，广泛的知识传播，并提供MetNet中心 培训学员的机会，以提高他们的技术和专业发展技能，行政核心 将支持一个虚拟的，每月的研讨会系列，并将提供内部MetNet中心的研究交流和50000美元 试点项目。在目标1中，行政核心将监督和协调项目使命， 多学科项目监督，并通过视频会议和面对面会议确定时间轴里程碑 会议.在目标2中，我们将开发，协调，安排和评估研究会议，研究座谈会， 以及对我们的研究使命和传播至关重要的访问科学家计划。在目标3中，我们 创建MetNet中心的网站，以：促进项目成果的交流; 为外部研究人员提供咨询;作为面向公众的研究成果来源， 告知乳腺癌患者社区;并作为所有中心的中央和可访问的存储库 生成的协议。