National Coordinating Center (NCC) for the Polycystic Kidney Disease (PKD) Research and Translation Core Centers

国家多囊肾病 (PKD) 研究和转化核心中心协调中心 (NCC)

基本信息

  • 批准号:
    10687258
  • 负责人:
  • 金额:
    $ 89.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-20 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary Polycystic Kidney Disease (PKD) is the most common inherited cause of renal failure worldwide. The genes responsible for the most frequent forms of PKD (PKD1, PKD2 and PKHD1) were identified over the past two decades. Progress over these years has led to improved tools for studying cyst formation and progression and these in turn have resulted in an improved understanding of PKD pathophysiology and, most recently, an approved therapy. Despite these advances, however, there is no intervention to halt cystic kidney disease or its systemic manifestations and there remains a pressing need for more effective treatments. In order to promote interdisciplinary and integrated approaches to the identification of novel therapeutic targets, an RFA has been issued to support PKD Research and Translation Core Centers (RTCCs) whose mission will be to develop innovative research tools. Here we establish a new National Coordinating Center (NCC) to provide highly organized administrative support to the RTCCs. We will implement a bold, innovative and outward- facing program that will facilitate collaboration and cohesion between the RTCCs and establish mechanisms for sharing of reagents and expertise broadly. The National Coordinating Center will seek to invigorate and energize research in PKD by supporting and expanding the community of PKD investigators, by promoting data driven science and by developing educational activities that encourage open and critical thinking and attract the brightest new talent to the study of PKD. Leadership of the National Coordinating Center will be provided by two investigators with an in-depth understanding of the PKD field and a deep belief in the importance of collaborative science. The NCC will support the goals of the PKD Research Consortium with the following Aims: 1) Convene the PKD Research Consortium Steering Committee to develop the program’s overall direction, to organize and execute program activities and to assist with broad dissemination of information 2) Develop a multipronged communication plan including an accessible web site for disseminating information about research resources 3) Facilitate collaboration between RTCCs by establishing a framework for joint development of resources 4) Facilitate broad sharing of resources across the consortium 5) Develop an educational program, including an annual scientific symposium that will encourage constructive discourse and diverse and creative approaches to PKD science. 6) Develop, support and execute a pilot and feasibility program that encourages new investigators (both early stage and established) to enter the field of PKD research. 7) Provide educational programming geared toward early stage investigators to foster the development of a new cohort of PKD researchers and leaders. In summary, the collaborative environment fostered by the NCC will catalyze advances that we expect will result in new insights into PKD pathobiology and new therapeutic options for patients with polycystic kidney disease.
项目摘要 多囊肾病(PKD)是全球肾衰竭最常见的遗传性原因。的基因 在过去的两年中,已经确定了负责最常见形式的PKD(PKD 1,PKD 2和PKHD 1)的基因。 几十年这些年来的进展导致了用于研究囊肿形成和进展的改进的工具, 这些反过来又导致了对PKD病理生理学的更好理解,最近, 批准的治疗。然而,尽管有这些进展,但没有干预措施来阻止囊性肾病, 它的全身表现,仍然迫切需要更有效的治疗。为了 促进跨学科和综合方法来识别新的治疗靶点,RFA 已发布,以支持PKD研究和翻译核心中心(RTCC),其使命将是 开发创新的研究工具。在这里,我们建立了一个新的国家协调中心, 向区域培训中心提供高度有组织的行政支助。我们将实施大胆、创新、外向的- 面向计划,将促进RTCC之间的合作和凝聚力,并建立机制 广泛分享试剂和专业知识。国家协调中心将努力振兴和 通过支持和扩大PKD研究人员的社区,通过促进 数据驱动的科学和发展教育活动,鼓励开放和批判性思维, 吸引最聪明的新人才到PKD的研究。国家协调中心的领导将是 由两名研究人员提供,他们对PKD领域有着深入的了解,并对 科学合作的重要性。NCC将支持PKD研究联盟的目标, 以下目标:1)召集PKD研究联盟指导委员会,制定该计划的 全面指导,组织和执行方案活动,并协助广泛传播 2)制定一项多管齐下的宣传计划,包括建立一个便于查阅的网站, 3)通过建立一个框架,促进区域合作中心之间的合作 4)促进在联合体内广泛分享资源5)发展 一个教育计划,包括一个年度科学研讨会,将鼓励建设性的话语 和多样性和创造性的方法来PKD科学。6)开发、支持和执行一项试点和可行性研究 一个鼓励新的研究者(包括早期和成熟的)进入PKD领域的计划 research. 7)提供面向早期调查人员的教育计划,以培养 培养一批新的PKD研究人员和领导者。总之,协作环境 NCC的支持将促进我们预期将导致对PKD病理生物学的新见解的进展 多囊肾的治疗方法有哪些

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Neuroimmune interplay in kidney health and disease: Role of renal nerves.
肾脏健康和疾病中的神经免疫相互作用:肾神经的作用。
  • DOI:
    10.1016/j.autneu.2023.103133
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Gauthier,MadelineM;Hayoz,Sebastien;Banek,ChristopherT
  • 通讯作者:
    Banek,ChristopherT
A song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE mice.
AA 与火之歌:高血压 SLE 小鼠不同性别依赖性肾脏炎症机制。
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Terry J Watnick其他文献

Terry J Watnick的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Terry J Watnick', 18)}}的其他基金

Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)
马里兰州多囊肾病研究与转化核心中心 (MPKD-RTCC)
  • 批准号:
    10693919
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10058977
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10693920
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10231256
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
National Coordinating Center (NCC) for the Polycystic Kidney Disease (PKD) Research and Translation Core Centers
国家多囊肾病 (PKD) 研究和转化核心中心协调中心 (NCC)
  • 批准号:
    10218161
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)
马里兰州多囊肾病研究与转化核心中心 (MPKD-RTCC)
  • 批准号:
    10231255
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)
马里兰州多囊肾病研究与转化核心中心 (MPKD-RTCC)
  • 批准号:
    10058976
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
National Coordinating Center (NCC) for the Polycystic Kidney Disease (PKD) Research and Translation Core Centers
国家多囊肾病 (PKD) 研究和转化核心中心协调中心 (NCC)
  • 批准号:
    10058889
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
Administrative Supplement to Watnick U54DK126114
Watnick U54DK126114 的行政补充
  • 批准号:
    10688699
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:
Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)
马里兰州多囊肾病研究与转化核心中心 (MPKD-RTCC)
  • 批准号:
    10456638
  • 财政年份:
    2020
  • 资助金额:
    $ 89.21万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 89.21万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了