Administrative Supplement to Watnick U54DK126114

整体项目总结 在这个应用中，我们建立了马里兰多囊肾病(PKD)的研究和翻译核心 中心(MPKD-RTCC)。该中心的使命是促进以下领域的翻译和基础研究 通过提供独特的资源、试剂和专业知识 调查人员基础广泛。这一建议利用了MPKD-RTCC在PKD研究方面的悠久传统 过去二十年来一直站在PKD科学前沿的研究人员。该中心由以下人员组成 4个高度协作和集成的生物医学研究核心，共同分发必要的 专门为PKD研究量身定做的试剂和专业知识的“工具箱”。MPKD-RTCC内核包括1) 抗体和载体2)小鼠模型和生物库3)细胞培养和工程4)临床和 翻译。每个核心都满足了从基础到临床的PKD研究管道中的一个关键需求 调查。此外，MPKD-RTCC核心领导人将针对PKD的感知需求开创解决方案 研究人员通过向创新方向拓展。我们希望这一战略将继续我们行之有效的道路。 在全国支持高影响力科学的记录。这些活动将由一个 管理核心由两名经验丰富的调查人员领导，他们将利用两个杰出的 巴尔的摩研究机构、马里兰大学巴尔的摩分校(UMB)和约翰霍普金斯大学 医学部。作为一个团队，他们将推动MPKD-RTCC对以下原则的基本承诺 通过简化SOP以共享高质量试剂和专业知识的协作科学，通过整合我们的 通过协调与PKD研究联盟内的其他区域技术合作中心的协作，开展核心活动。 该中心的具体目标是：1)向国家组织提供关键的最先进的试剂和专业知识 2)向非PKD调查人员提供关键的尖端试剂和专业知识 为了消除与PKD相关研究的障碍3)开发创新的试剂和资源 PKD领域的先进生物医学发现，以推动MPKD-RTCC核心和 PKD研究联盟内的其他RTCC以及5)与其他RTCC合作，该联盟 包括NIDDK在内的指导委员会，以实现PKD研究联盟的总体目标。 通过扩大跨学科合作，我们希望催化生物医学的翻译 将防止多囊肾病及其后果进展的发现。

Overall Project Summary In this application we establish the Maryland Polycystic Kidney Disease (PKD) Research and Translation Core Center (MPKD-RTCC). The mission of this Center is to facilitate translational and basic research in the field of polycystic kidney disease and related disciplines by providing unique resources, reagents and expertise to a broad base of investigators. This proposal capitalizes on a long tradition of PKD research by MPKD-RTCC investigators who have been at the forefront of PKD science for the past two decades. The Center consists of 4 highly collaborative and integrated biomedical research cores that together will distribute an essential “toolbox” of reagents and expertise tailored specifically to PKD research. The MPKD-RTCC cores include 1) Antibody and Vector 2) Mouse Models and Biobank 3) Cell Culture and Engineering and 4) Clinical and Translation. Each core addresses a critical need in the PKD research pipeline, stretching from basic to clinical investigation. In addition, MPKD-RTCC core leaders will pioneer solutions to perceived needs among PKD Researchers by expanding in innovative directions. We expect that this strategy will continue our proven track record of supporting high impact science across the country. These activities will be organized by an Administrative Core led by two experienced investigators who will leverage the resources of two outstanding research institutions in Baltimore, the University of Maryland Baltimore (UMB) and the Johns Hopkins School of Medicine. As a team they will drive the MPKD-RTCC’s fundamental commitment to the principle of collaborative science by streamlining SOPs for sharing high quality reagents and expertise, by integrating our the core’s activities and by coordinating collaboration with other RTCCs within the PKD Research Consortium. The Center’s Specific Aims are: 1) To provide critical state of the art reagents and expertise to a national group of PKD investigators 2) To provide critical state of the art reagents and expertise to non-PKD investigators in order to remove barriers to PKD related research 3) To develop innovative reagents and resources that will advance biomedical discoveries in the field of PKD 4) To drive collaboration between MPKD-RTCC Cores and other RTCCs within the PKD Research Consortium and 5) To partner with other RTCCs, the consortium steering committee including the NIDDK to achieve the overall goals of the PKD Research Consortium. Through expanded interdisciplinary collaborations, we hope to catalyze the translation of biomedical discoveries that will prevent progression of polycystic kidney disease and its consequences.