Center for Childhood Obesity Prevention

儿童肥胖预防中心

• 批准号: 10689804
• 负责人: JUDITH Lynne WEBER
• 金额: $ 229.72万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689804
• 关键词: 4 year old; Address; Adolescent; Adolescent obesity; Arkansas; Asthma; Behavior; Biomedical Research; Burn injury; Caring; Child; Child Health; Classification; Clinical; Collaborations; Communities; Complex; Contracts; Development; Diabetes Mellitus; Dietary Proteins; Disease; Education; Emotional; Energy Metabolism; Ensure; Environment; Epidemiology; Evidence based practice; Food; Goals; Health; Hypertension; Institution; Insulin Resistance; Intervention; Investments; Leadership; Link; Low income; Maintenance; Malignant Neoplasms; Mentors; Metabolic; Mitochondria; Modeling; Muscle function; Obesity; Outcome; Overweight; Pathway interactions; Phase; Phenotype; Physical activity; Pilot Projects; Policies; Population; Prevalence; Prevention strategy; Problem behavior; Procedures; Process; Program Development; Protons; Public Health; Recommendation; Regulation; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rights; Role; Sampling; School-Age Population; Schools; Science; Scientist; Secure; Series; Sleep Disorders; Strategic Planning; System; Teacher Professional Development; Testing; Time; Training; Training Programs; United States; United States National Institutes of Health; Work; Youth; cardiorespiratory fitness; career development; comorbidity; dietary; disorder prevention; energy balance; evidence base; exercise intensity; fitness; fundamental research; improved; innovation; metabolic rate; multidisciplinary; non-alcoholic fatty liver disease; obesity in children; obesity prevention; operation; overweight child; programs; protein intake; recruit; research facility; severe burns; social; translational pipeline

PROJECT SUMMARY The goal of this application is to further develop an integrated, multidisciplinary and translational Center for Childhood Obesity Prevention (CCOP) that will be sustained within the Arkansas Children’s Research Institute. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. In the United States, nearly 1 in 5 school age youth have obesity (1). Among school-age youth in Arkansas, 23% have obesity and 17% are classified as overweight (2). Further, the prevalence of hypertension (4-6), and other obesity-related co-morbidities, have increased dramatically over the last two decades. Additionally, obesity and obesity-promoting behaviors are also linked to a variety of cancers (16). To address this complex problem, a group of emerging scientists recruited in Phase 1 will continue to build their collaborative work in elucidating causes, and testing interventions, to stop the rise and ultimately reduce the prevalence of child overweight and obesity and corresponding comorbidities. In order to establish a broad-based, multi-disciplinary disease prevention center, rooted in a team science approach, projects span the full translational continuum, bringing together research in complex disease origins, epidemiology, and social systems. Ongoing recruitment of additional research project leaders and pilot study investigators will continue to build a critical mass of scientists focused on building the base of evidence for strategies to address the childhood obesity crisis and improve child health. Specific Aim 1: Further enhance the research infrastructure established in Phase 1 to support the Center. Critical institutional support and strong collaborations with multiple key institutional and community partners have been established, and will continue to be enhanced, to provide junior investigators’ access to state-of-the-art biomedical research facilities and resources to pursue inquiry focused on the theme of childhood obesity prevention. Specific Aim 2: Continue to build on the successful faculty development program implemented in Phase 1. The career development training program established in Phase 1 in partnership with the UAMS CTSA’s Research Fundamentals program will continue to be strengthened. A “best practices” senior mentoring program combines a Senior Mentor Rights and Responsibilities contract with guidance from a Senior Mentoring Leadership Team approach. Specific Aim 3: Ensure robust operations and pathway to sustainability for the Center for Childhood Obesity Prevention. Comprehensive operational procedures for managing the Center’s fiscal, regulatory, project development, and research core viability processes were established, and will continue to be strengthened. Significant institutional investment has been secured, and will be leveraged to ensure long term sustainability of the Center.

项目摘要 该申请的目标是进一步发展一个综合的，多学科的和翻译中心 儿童肥胖预防（CCOP）计划将在阿肯色州儿童中心内持续开展 研究院儿童肥胖症是一个国家公共卫生威胁， 阿肯色州。在美国，近五分之一的学龄青少年患有肥胖症（1）。在学龄青年中， 在阿肯色州，23%的人肥胖，17%的人超重（2）。此外，高血压的患病率 (4-6)以及其他与肥胖相关的并发症在过去二十年中急剧增加。 此外，肥胖和促进肥胖的行为也与各种癌症有关（16）。解决 在这个复杂的问题上，第一阶段招募的一组新兴科学家将继续建立他们的 在阐明原因和测试干预措施方面的合作，以阻止上升并最终减少 儿童超重和肥胖的患病率以及相应的合并症。 为了建立一个基础广泛，多学科的疾病预防中心，扎根于一支队伍 科学的方法，项目跨越整个翻译连续体，汇集了复杂的研究 疾病起源、流行病学和社会制度。正在征聘更多的研究项目负责人 试点研究的研究人员将继续建立一个关键的科学家质量，重点是建立基础， 为解决儿童肥胖危机和改善儿童健康的战略提供证据。 具体目标1：进一步加强第一阶段建立的研究基础设施， 中心。关键的机构支持和与多个关键机构和社区的强有力合作 已经建立并将继续加强合作伙伴，为初级调查员提供 国家的最先进的生物医学研究设施和资源，以追求调查的主题集中在 儿童肥胖症的预防 具体目标2：继续建立在成功的教师发展计划实施 第一阶段。与UAMS合作在第一阶段建立的职业发展培训计划 CTSA的研究基础计划将继续得到加强。“最佳做法”高级指导 该计划将高级导师的权利和责任合同与高级导师的指导相结合， 指导领导团队方法。 具体目标3：确保中心的稳健运作和可持续发展途径， 儿童肥胖症的预防全面的业务程序，管理中心的财政， 建立了监管、项目开发和研究核心可行性流程，并将继续 强化已经获得了大量的机构投资，并将利用这些投资来确保长期的 中心的可持续性。

项目成果

Prevalence and associations between food insecurity and overweight/obesity among native Hawaiian and Pacific Islander adolescents.

• DOI: 10.1017/s1368980023000769
• 发表时间: 2023-07
• 期刊: PUBLIC HEALTH NUTRITION
• 影响因子: 3.2
• 作者: Long, Christopher R.;Narcisse, Marie-Rachelle;Selig, James P.;Willis, Don E.;Gannon, Matthew;Rowland, Brett;English, Emily S.;McElfish, Pearl A.
• 通讯作者: McElfish, Pearl A.

Implementation fidelity, attitudes, and influence: a novel approach to classifying implementer behavior.

• DOI: 10.1186/s43058-022-00307-0
• 发表时间: 2022-06-06
• 期刊: Implementation science communications

Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity.

• DOI: 10.3389/fendo.2020.00654
• 发表时间: 2020
• 期刊: Frontiers in endocrinology
• 影响因子: 5.2
• 作者: Tas E;Bai S;Ou X;Mercer K;Lin H;Mansfield K;Buchmann R;Diaz EC;Oden J;Børsheim E;Adams SH;Dranoff J
• 通讯作者: Dranoff J

Circulating long-chain acylcarnitine concentrations are not affected by exercise training in pregnant women with obesity.

肥胖孕妇的循环长链酰基肉碱浓度不受运动训练的影响。

• DOI: 10.1152/japplphysiol.00712.2021
• 发表时间: 2022
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Allman,BrittanyR;Spray,BeverlyJ;Lan,RennyS;Andres,Aline;Børsheim,Elisabet
• 通讯作者: Børsheim,Elisabet

Assessing the acceptability and implementation feasibility of a culturally adapted parenting intervention for Marshallese mothers: A study protocol.

• DOI: 10.1016/j.conctc.2023.101240
• 发表时间: 2024-02
• 期刊: Contemporary clinical trials communications
• 影响因子: 1.5