Center for Childhood Obesity Prevention

儿童肥胖预防中心

• 批准号: 10270950
• 负责人: JUDITH Lynne WEBER
• 金额: $ 233.87万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270950
• 关键词: 4 year old; Address; Adolescent; Adolescent obesity; Arkansas; Asthma; Behavior; Biomedical Research; Burn injury; Caring; Child; Child Health; Clinical; Collaborations; Communities; Complex; Contracts; Diabetes Mellitus; Dietary Proteins; Disease; Education; Emotional; Energy Metabolism; Ensure; Environment; Epidemiology; Evidence based practice; Food; Goals; Health; Hypertension; Insulin Resistance; Intervention; Investments; Leadership; Link; Low income; Maintenance; Malignant Neoplasms; Mentors; Metabolic; Mitochondria; Modeling; Muscle function; Obesity; Outcome; Overweight; Pathway interactions; Phase; Phenotype; Physical activity; Pilot Projects; Plant Roots; Policies; Population; Prevalence; Prevention strategy; Problem behavior; Procedures; Process; Program Development; Protons; Public Health; Regulation; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rights; Role; Sampling; School-Age Population; Schools; Science; Scientist; Secure; Series; Sleep Disorders; Strategic Planning; System; Teacher Professional Development; Testing; Time; Training; Training Programs; United States; United States National Institutes of Health; Work; Youth; base; cardiorespiratory fitness; career development; comorbidity; dietary; disorder prevention; energy balance; evidence base; exercise intensity; fitness; fundamental research; improved; innovation; metabolic rate; multidisciplinary; non-alcoholic fatty liver disease; obesity in children; obesity prevention; operation; overweight child; programs; protein intake; recruit; research and development; research facility; severe burns; social; translational pipeline

PROJECT SUMMARY The goal of this application is to further develop an integrated, multidisciplinary and translational Center for Childhood Obesity Prevention (CCOP) that will be sustained within the Arkansas Children’s Research Institute. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. In the United States, nearly 1 in 5 school age youth have obesity (1). Among school-age youth in Arkansas, 23% have obesity and 17% are classified as overweight (2). Further, the prevalence of hypertension (4-6), and other obesity-related co-morbidities, have increased dramatically over the last two decades. Additionally, obesity and obesity-promoting behaviors are also linked to a variety of cancers (16). To address this complex problem, a group of emerging scientists recruited in Phase 1 will continue to build their collaborative work in elucidating causes, and testing interventions, to stop the rise and ultimately reduce the prevalence of child overweight and obesity and corresponding comorbidities. In order to establish a broad-based, multi-disciplinary disease prevention center, rooted in a team science approach, projects span the full translational continuum, bringing together research in complex disease origins, epidemiology, and social systems. Ongoing recruitment of additional research project leaders and pilot study investigators will continue to build a critical mass of scientists focused on building the base of evidence for strategies to address the childhood obesity crisis and improve child health. Specific Aim 1: Further enhance the research infrastructure established in Phase 1 to support the Center. Critical institutional support and strong collaborations with multiple key institutional and community partners have been established, and will continue to be enhanced, to provide junior investigators’ access to state-of-the-art biomedical research facilities and resources to pursue inquiry focused on the theme of childhood obesity prevention. Specific Aim 2: Continue to build on the successful faculty development program implemented in Phase 1. The career development training program established in Phase 1 in partnership with the UAMS CTSA’s Research Fundamentals program will continue to be strengthened. A “best practices” senior mentoring program combines a Senior Mentor Rights and Responsibilities contract with guidance from a Senior Mentoring Leadership Team approach. Specific Aim 3: Ensure robust operations and pathway to sustainability for the Center for Childhood Obesity Prevention. Comprehensive operational procedures for managing the Center’s fiscal, regulatory, project development, and research core viability processes were established, and will continue to be strengthened. Significant institutional investment has been secured, and will be leveraged to ensure long term sustainability of the Center.

项目摘要 该应用程序的目的是进一步开发一个综合，多学科和翻译中心 为了预防儿童肥胖症（CCOP），将在阿肯色州儿童中维持 研究所。儿童肥胖是一种国家公共卫生威胁，在 阿肯色州。在美国，几乎有五分之一的年龄年轻人患有肥胖症（1）。在学龄的年轻人中 阿肯色州，23％的肥胖症，17％被归类为超重（2）。此外，高血压的患病率 （4-6）和其他与肥胖相关的合并症在过去的二十年中急剧增加。 另外，肥胖和肥胖行为也与各种癌症有关（16）。解决 这个复杂的问题，在第1阶段招募的一群新兴科学家将继续建立他们的 在阐明原因和测试干预措施方面的协作工作，以阻止上升并最终减少 儿童超重和肥胖的患病率以及相应的合并症。 为了建立一个植根于团队的广泛的多学科疾病预防中心 科学方法，项目涵盖了完整的转化连续性，将复杂的研究整合在一起 疾病起源，流行病学和社会系统。持续招募其他研究项目负责人 试点研究调查人员将继续建立一大批专注于建立基础的科学家 解决儿童肥胖危机并改善儿童健康的策略的证据。 特定目的1：进一步增强在第1阶段建立的研究基础设施以支持 中心。与多个关键机构和社区的重要机构支持以及强有力的合作 已经建立了合作伙伴，并将继续得到增强，以提供初级调查人员的访问权限 最先进的生物医学研究设施和资源以追求询问的重点是 儿童肥胖预防。 特定目标2：继续建立在实施的成功教师发展计划的基础上 在第1阶段。与UAMS合作建立的职业发展培训计划 CTSA的研究基础计划将继续得到加强。 “最佳实践”高级心理 计划将高级导师权利和责任合同与高级指导相结合 指导领导团队方法。 特定目的3：确保为中心的强大操作和可持续性途径 儿童肥胖预防。管理中心财政的全面操作程序， 建立了监管，项目开发和研究核心生存能过程，并将继续 得到加强。已经确保了大量的机构投资，并将利用以确保长期 中心的期限可持续性。