Center for Childhood Obesity Prevention

项目摘要 在美国，儿童肥胖对公共健康的威胁日益严重。该中心的目标是 阿肯色州儿童研究所（阿克里）的儿童肥胖预防（CCOP）旨在减少儿童 儿童肥胖率通过综合，跨学科和转化研究。为了实现 生物医学研究卓越中心（COBRE）资助机制，以支持建立 和发展创新，国家的最先进的生物医学研究中心的机构在机构 发展奖资格的国家，CCOP已经建立了一个代谢和生物能量学核心（MBC）， 向CCOP调查人员提供关键的生物医学研究服务。 此仪器补充应用程序将用于购买啮齿动物代谢和行为 表型系统这一关键仪器将使MBC能够提供重要的啮齿动物表型分析 为CCOP调查员提供服务。因此，这一补编将大大加强CCOP的利用， 最先进的代谢和行为表型分析仪器。 除了肥胖，我们的身体如何代谢和分配燃料的改变与几种疾病的病因有关。 慢性病因此，准确地确定啮齿动物进食行为、活动、底物 实时的代谢和能量消耗提供了丰富的重要的表型数据， 使用啮齿动物模型的基础研究的影响。由于阿克里是两个国家研究所的所在地， 一般医学科学COBRE奖，这种仪器补充是很好的定位，以显着 通过增加获得关键信息的机会，增强NIGMS资助的众多研究项目的影响力 仪器仪表

PROJECT SUMMARY Childhood obesity is a growing threat to public health in the United States. The goal of the Center for Childhood Obesity Prevention (CCOP) at Arkansas Children's Research Institute (ACRI) is to reduce childhood obesity rates in children through integrated, interdisciplinary and translational research. In line with the goals of the Centers of Biomedical Research Excellence (COBRE) funding mechanism, to support the establishment and development of innovative, state-of-the-art biomedical research centers at institutions in Institutional Development Award-eligible states, the CCOP has established a Metabolism and Bioenergetics Core (MBC) to make critical biomedical research services available to CCOP investigators. This instrumentation supplement application will be used to purchase a rodent metabolic and behavioral phenotyping system. This key instrumentation will allow the MBC to provide important rodent phenotyping services to CCOP investigators. Accordingly, this supplement will significantly enhance access for CCOP investigators to state-of-the-art metabolic and behavioral phenotyping instrumentation. Beyond obesity, alterations in how our bodies metabolize and partition fuel is linked to the etiology of several chronic diseases. Accordingly, platforms that accurately determine rodent feeding behavior, activity, substrate metabolism and energy expenditure in real-time provide a wealth of important phenotypic data that increase the impact of basic research employing rodent models. Since ACRI is home to two National Institutes for General Medical Sciences COBRE awards, this instrumentation supplement is well positioned to significantly enhance the impact of numerous NIGMS funded research projects by enhancing access to critical instrumentation.