Center for Childhood Obesity Prevention

儿童肥胖预防中心

• 批准号: 10397299
• 负责人: JUDITH Lynne WEBER
• 金额: $ 24.27万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10397299
• 关键词: Administrative Supplement; Arkansas; Award; Basic Science; Bioenergetics; Biology; Biomedical Research; Centers of Research Excellence; Child; Chronic Disease; Data; Development; Energy Metabolism; Etiology; Exercise; Feeding behaviors; Funding; Funding Mechanisms; Goals; Habits; Health; Home; Institution; Interdisciplinary Study; Link; Metabolic; Metabolism; National Institute of General Medical Sciences; Obesity; Phenotype; Positioning Attribute; Public Health; Research Institute; Research Personnel; Research Project Grants; Rodent; Rodent Model; Services; System; Time; Translational Research; United States; behavioral phenotyping; excessive weight gain; innovation; instrumentation; metabolic phenotype; obesity in children; obesity prevention; phenotypic data; pre-clinical research; prevent

PROJECT SUMMARY Childhood obesity is a growing threat to public health in the United States. The goal of the Center for Childhood Obesity Prevention (CCOP) at Arkansas Children's Research Institute (ACRI) is to reduce childhood obesity rates in children through integrated, interdisciplinary and translational research. In line with the goals of the Centers of Biomedical Research Excellence (COBRE) funding mechanism, to support the establishment and development of innovative, state-of-the-art biomedical research centers at institutions in Institutional Development Award-eligible states, the CCOP has established a Metabolism and Bioenergetics Core (MBC) to make critical biomedical research services available to CCOP investigators. This instrumentation supplement application will be used to purchase a rodent metabolic and behavioral phenotyping system. This key instrumentation will allow the MBC to provide important rodent phenotyping services to CCOP investigators. Accordingly, this supplement will significantly enhance access for CCOP investigators to state-of-the-art metabolic and behavioral phenotyping instrumentation. Beyond obesity, alterations in how our bodies metabolize and partition fuel is linked to the etiology of several chronic diseases. Accordingly, platforms that accurately determine rodent feeding behavior, activity, substrate metabolism and energy expenditure in real-time provide a wealth of important phenotypic data that increase the impact of basic research employing rodent models. Since ACRI is home to two National Institutes for General Medical Sciences COBRE awards, this instrumentation supplement is well positioned to significantly enhance the impact of numerous NIGMS funded research projects by enhancing access to critical instrumentation.

项目总结