Neural mechanisms of maturing out of problem alcohol use

摆脱酗酒问题的成熟神经机制

• 批准号: 10704169
• 负责人: Jillian Elizabeth Hardee
• 金额: $ 60.23万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704169
• 关键词: Accounting; Adolescent and Young Adult; Age; Alcohol abuse; Alcohol consumption; Alcohols; Amygdaloid structure; Anxiety; Behavior; Behavioral Mechanisms; Brain; Cues; Data; Data Analyses; Data Collection; Development; Disinhibition; Drug usage; Emotional; Emotions; Esthesia; Female; Functional Magnetic Resonance Imaging; Gender; Heavy Drinking; Image; Impulsivity; Individual; Intervention; Knowledge; Limbic System; Magnetic Resonance Imaging; Marriage; Measurement; Measures; Mental Depression; Methods; Modeling; Neurobiology; Neuropsychology; Outcome; Participant; Patient Self-Report; Pattern; Play; Process; Psychosocial Assessment and Care; Relapse; Reporting; Research; Resolution; Rest; Rewards; Risk; Risk Behaviors; Risk Factors; Role; Sampling; Scanning; Sex Differences; Social Environment; Structure; System; Testing; Time; Woman; alcohol cue; alcohol effect; alcohol risk; alcohol use disorder; behavior prediction; binge drinker; binge drinking; cognitive control; coping; cue reactivity; design; drinking; efficacious treatment; emerging adulthood; emotion dysregulation; emotion regulation; executive function; follow up assessment; follow-up; functional MRI scan; improved; improved outcome; individualized medicine; lifetime risk; male; men; multimodality; neural; neural patterning; neurobehavioral; neurodevelopment; neuroimaging; neuromechanism; neurotoxic; novel; predictive marker; problem drinker; psychosocial; recruit; resilience; response; sex; stem; young adult

ABSTRACT There is a normative decrease in problem alcohol use that naturally occurs in the mid-20s after binge and heavy drinking peak, a process called “maturing out”. While most young adults mature out of problem use, a subset persist or escalate in their drinking; these individuals are at risk for lifetime struggles with alcohol use disorders. What differentiates those who mature out of problem drinking versus those who do not is not fully understood. Developmental changes in the brain are hypothesized to play a central role in the alcohol consumption shifts that define the maturing out period, as neural maturation is not fully complete until the mid- 20s. Furthermore, young adulthood is a critical neurodevelopmental period when subcortical emotion and reward-related and cortical cognitive control regions mature, concomitant with improvements in executive control and declines in impulsivity and sensation-seeking. Despite the presumed effect that neural maturation has on decreases in risky behavior (like heavy alcohol use), no study has directly tested associations between neurobiological processes and trajectories of alcohol use in young adulthood. For this study, we will recruit 400 individuals between the ages of 21 and 25 (50% female) who report at least one binge drinking episode a month for the past 3 months to undergo high-resolution structural magnetic resonance and functional imaging scans (cognitive control, emotion regulation, alcohol cue reactivity, and resting state) at baseline. Detailed neuropsychological and psychosocial measurements will also be collected. Follow-up assessments will consist of 1) self-report alcohol use, measured online every 3 months post-scan to examine trajectories of use, and 2) neuropsychological and psychosocial measurements, collected online every year post-scan. Participants will be recruited during Years 1–3. Follow-up assessments will be collected until the end of the study, maximizing the data collection period and allowing for a large follow-up age range (25–29 years). We will model alcohol use trajectories across time, using baseline imaging data as a marker to differentiate or predict participants who persist or desist in use. This design will allow us to 1) determine the extent to which neural and behavioral mechanisms of cognitive control, emotion regulation, and reward/cue reactivity predict drinking trajectories, and 2) examine the effect of problem drinking on these processes. As sex differences in cognitive control, emotion, and reward development likely introduce variability in alcohol use, 3) we will also characterize sex differences predictive of alcohol use trajectories. As an exploratory analysis, we will investigate neurobiological predictors of maturing out using multimodal (structure, resting state, task) MRI data analysis.

抽象的 饮酒的问题正常减少，在暴饮暴食后自然发生在20年代中期 大量饮酒峰，一个称为“成熟”的过程。虽然大多数年轻人出于问题的使用而成熟，但 子集在喝酒中持续或升级；这些人有终身饮酒的风险 疾病。那些因饮酒而与不完全饮酒的人区分开的是什么 理解。假设大脑的发育变化在酒精中起着核心作用 消费转移定义了成熟时期的变化，因为直到中期才完全完成神经饱和度 20年代。此外，年轻的成年是下皮质情绪和 与奖励相关的皮质认知控制区域成熟，与执行 冲动和寻求感觉的控制和下降。尽管表明了中性成熟 风险行为的下降（例如大量饮酒），没有任何研究直接测试 成年年轻的神经生物学过程和饮酒的轨迹。 在这项研究中，我们将招募400名21至25岁的人（女性）至少报告 在过去3个月的一个月中，每月一次一次暴饮暴食，以进行高分辨率结构磁 共振和功能成像扫描（认知控制，情绪调节，酒精提示反应性和 静止状态）基线。还将收集详细的神经心理学和社会心理测量。 后续评估将包括1）自我报告饮酒，在扫描后每3个月在线测量 检查使用轨迹，以及2）在线收集的神经心理学和社会心理测量 扫描后每年。参与者将在1 - 3年内招募。将收集后续评估 直到研究结束，使数据收集期最大化并允许大量随访年龄范围 （25 - 29年）。我们将使用基线成像数据作为标记来对酒精使用轨迹进行建模 区分或预测坚持使用或渴望的参与者。该设计将使我们到1）确定 认知控制，情绪调节和奖励/提示的神经和行为机制的程度 反应性预测饮酒轨迹，2）检查饮用问题对这些过程的影响。作为 认知控制，情绪和奖励发展的性别差异可能会引入酒精使用变化， 3）我们还将表征性别差异的预测饮酒轨迹。作为探索性分析， 我们将研究使用多模式（结构，静止状态，任务）成熟的神经生物学预测指标 MRI数据分析。