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Sex differences in the neural mechanisms of brief interventions for binge drinking

酗酒短暂干预神经机制的性别差异

基本信息

批准号：
9087556
负责人：
Jillian Elizabeth Hardee
金额：
$ 16.61万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9087556
关键词：
Address Age Alcohol abuse Alcohol consumption Alcohol dependence Alcoholic beverage heavy drinker Alcohols Aptitude Area Arousal Award Behavior Behavior Control Behavioral Behavioral Mechanisms Biomedical Engineering Brain Brief Alcohol Screening and Intervention for College Students Cessation of life Clinical Control Groups Cues Data Development Education Emotional Emotions Environment Faculty Female Foundations Functional Magnetic Resonance Imaging Funding Funding Agency Future Goals Impulsivity Individual Individual Differences Injury Interdisciplinary Study Intervention Knowledge Laboratories Lead Link Longitudinal Studies MRI Scans Measurement Measures Memory impairment Mentors Mentorship Methodology Michigan Motivation Names National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Neural Pathways Neurobiology Neurosciences Outcome Overdose Pathway interactions Pattern Play Prevention program Prevention strategy Process Psychiatry Psychology Psychopathology Radiology Specialty Reading Recruitment Activity Research Research Personnel Research Project Grants Research Scientist Award Research Training Risk Risk Factors Role Scanning Schedule Scientist Sex Characteristics Substance abuse problem Techniques Time Training Translational Research Treatment outcome Universities University Health Services Unsafe Sex Work addiction aged alcohol cue alcohol intervention alcohol related consequences alcohol related problem alcohol use disorder arm base binge drinker binge drinking brief alcohol intervention brief alcohol screening brief intervention career college cue reactivity disorder risk drinking experience fighting follow-up high risk drinking improved outcome intervention effect intervention program male meetings mid-career faculty motivational enhancement therapy negative affect neural correlate neuroimaging neuromechanism physical assault problem drinker professor programs public health relevance relating to nervous system remediation sex sexual assault stem success treatment strategy university student vandalism young adult

项目摘要

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Award will support me in establishing an independent research career using neuroimaging to investigate the role of individual differences in alcohol use disorder risk and treatment outcomes. The training component of this application builds on my neuroscience and neuroimaging background, which demonstrates a strong technical aptitude and provides a robust basic scientific foundation from which to study the psychopathology of substance risk. To achieve full research independence, I have identified four key training objectives: 1) obtain experience in a clinical setting in order to understand all aspects of alcohol use disorders and their treatment; 2 gain expertise in the area of sex differences and addiction; 3) acquire advanced training in statistical methodologies; and 4) increase knowledge about brief interventions and motivational interviewing techniques. I will be mentored through this process by Dr. Maureen Walton, Associate Professor, Department of Psychiatry at the University of Michigan, and Dr. Mary Heitzeg, Assistant Professor, Department of Psychiatry, University of Michigan. A team of carefully selected consultants will provide additional guidance and training. The proposed K01 project will take place within the University of Michigan Addiction Research Center (UMARC), Department of Psychiatry, a multidisciplinary research center that has been funded by NIAAA, NIDA, NIMH, and a number of other external funding sources to address addiction problems, their causes, and their remediation. Eighty other substance abuse research projects are active on the University of Michigan campus, and UMARC faculty interact and collaborate with these other scientists. The University's Functional MRI Laboratory is also a collaborative, interdisciplinary facility used by a number of researchers across many departments, including Psychiatry, Psychology, Biomedical Engineering, and Radiology, just to name a few. The University of Michigan's vigorous research environment nurtures an expanding group of neuroimaging researchers, including Dr. Heitzeg, who has been the lead of the neuroimaging arm of the Michigan Longitudinal Study for 8 years and was the recipient of a NIDA Early Career Investigator Award for her work in developmental neuroimaging and addiction. The research component focuses on identifying whether there are differences between male and female collegiate binge drinkers in neural regions associated with risk for alcohol use disorders--impulse control, emotion processing, and alcohol cue reactivity--and how these regions change after a brief intervention. There is substantial behavioral evidence for disparities in risk trajectories such that females tend to score higher of measures of negative affect and males tend to score higher on measures of impulsivity. This can extend into young adulthood when binge drinking and negative consequences stemming from this type of behavior becomes problematic. Additionally, brief interventions have been shown to be effective for collegiate binge drinkers, with some mixed outcomes regarding male and female success rates. How sex differences moderate the neurobiology of addiction is understudied; a more careful examination of these differences would be beneficial for the development of targeted prevention and intervention programs. Here, functional magnetic resonance imaging (fMRI) will be conducted in two groups of binge drinking college students between the ages of 18-20yrs, with equal numbers of males and females in each group (n=100 total). One group (BI group) will be recruited from the University of Michigan University Health Services BASICS program (a brief alcohol intervention program for college students), and will partake in a baseline fMRI scan prior to beginning the program, and a follow-up scan immediately after the program finishes. The other group (Control group) will be recruited from campus and will only receive educational information about alcohol use. They will partake in a baseline and follow-up fMRI scan on the same time schedule as the BI group. Measures of emotional functioning, drinking motives, alcohol consumption, and alcohol-related problems will be measured at each scan, as well as 3 and 6 months post-scan. The research specific aims are: 1) examine sex differences in binge drinking risk factors, motivations, and underlying neural correlates at baseline in collegiate bing drinkers; 2) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking; and 3) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking. I will accomplish these research and training goals through close mentorship from a team with expertise in these content areas, didactic coursework, and directed readings.