Sex differences in the neural mechanisms of brief interventions for binge drinking

酗酒短暂干预神经机制的性别差异

• 批准号: 10001409
• 负责人: Jillian Elizabeth Hardee
• 金额: $ 16.61万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10001409
• 关键词: Address; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Aptitude; Area; Arousal; Award; Behavior; Behavior Control; Behavioral; Behavioral Mechanisms; Biomedical Engineering; Brain; Brief Alcohol Screening and Intervention for College Students; Cessation of life; Clinical; Control Groups; Cues; Data; Development; Education; Emotional; Emotions; Environment; Faculty; Female; Foundations; Functional Magnetic Resonance Imaging; Funding; Funding Agency; Future; Goals; Impulse Control Disorders; Impulsivity; Individual; Individual Differences; Injury; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Lead; Link; Longitudinal Studies; Measurement; Measures; Memory impairment; Mentors; Mentorship; Methodology; Michigan; Motivation; Names; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Neurobiology; Neurosciences; Outcome; Overdose; Pathway interactions; Pattern; Play; Prevention program; Prevention strategy; Preventive Intervention; Process; Psychiatry; Psychology; Psychopathology; Radiology Specialty; Reading; Research; Research Personnel; Research Project Grants; Research Scientist Award; Research Training; Risk; Risk Factors; Role; Scanning; Schedule; Scientist; Sex Differences; Substance abuse problem; Techniques; Time; Training; Translational Research; Treatment outcome; Universities; University Health Services; Unsafe Sex; Work; addiction; aged; alcohol cue; alcohol related consequences; alcohol related problem; alcohol risk; alcohol use disorder; arm; base; binge drinker; binge drinking; brief alcohol intervention; brief intervention; career; college; college drinking; comorbidity; cue reactivity; disorder risk; drinking; emotional functioning; experience; fighting; follow-up; functional MRI scan; group intervention; high risk drinking; improved outcome; intervention effect; intervention program; male; mid-career faculty; motivational enhancement therapy; negative affect; neural correlate; neuroimaging; neuromechanism; physical assault; problem drinker; professor; programs; public health relevance; recruit; relating to nervous system; remediation; sex; sexual assault; stem; success; treatment strategy; undergraduate student; university student; vandalism; young adult

 DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Award will support me in establishing an independent research career using neuroimaging to investigate the role of individual differences in alcohol use disorder risk and treatment outcomes. The training component of this application builds on my neuroscience and neuroimaging background, which demonstrates a strong technical aptitude and provides a robust basic scientific foundation from which to study the psychopathology of substance risk. To achieve full research independence, I have identified four key training objectives: 1) obtain experience in a clinical setting in order to understand all aspects of alcohol use disorders and their treatment; 2 gain expertise in the area of sex differences and addiction; 3) acquire advanced training in statistical methodologies; and 4) increase knowledge about brief interventions and motivational interviewing techniques. I will be mentored through this process by Dr. Maureen Walton, Associate Professor, Department of Psychiatry at the University of Michigan, and Dr. Mary Heitzeg, Assistant Professor, Department of Psychiatry, University of Michigan. A team of carefully selected consultants will provide additional guidance and training. The proposed K01 project will take place within the University of Michigan Addiction Research Center (UMARC), Department of Psychiatry, a multidisciplinary research center that has been funded by NIAAA, NIDA, NIMH, and a number of other external funding sources to address addiction problems, their causes, and their remediation. Eighty other substance abuse research projects are active on the University of Michigan campus, and UMARC faculty interact and collaborate with these other scientists. The University's Functional MRI Laboratory is also a collaborative, interdisciplinary facility used by a number of researchers across many departments, including Psychiatry, Psychology, Biomedical Engineering, and Radiology, just to name a few. The University of Michigan's vigorous research environment nurtures an expanding group of neuroimaging researchers, including Dr. Heitzeg, who has been the lead of the neuroimaging arm of the Michigan Longitudinal Study for 8 years and was the recipient of a NIDA Early Career Investigator Award for her work in developmental neuroimaging and addiction. The research component focuses on identifying whether there are differences between male and female collegiate binge drinkers in neural regions associated with risk for alcohol use disorders--impulse control, emotion processing, and alcohol cue reactivity--and how these regions change after a brief intervention. There is substantial behavioral evidence for disparities in risk trajectories such that females tend to score higher of measures of negative affect and males tend to score higher on measures of impulsivity. This can extend into young adulthood when binge drinking and negative consequences stemming from this type of behavior becomes problematic. Additionally, brief interventions have been shown to be effective for collegiate binge drinkers, with some mixed outcomes regarding male and female success rates. How sex differences moderate the neurobiology of addiction is understudied; a more careful examination of these differences would be beneficial for the development of targeted prevention and intervention programs. Here, functional magnetic resonance imaging (fMRI) will be conducted in two groups of binge drinking college students between the ages of 18-20yrs, with equal numbers of males and females in each group (n=100 total). One group (BI group) will be recruited from the University of Michigan University Health Services BASICS program (a brief alcohol intervention program for college students), and will partake in a baseline fMRI scan prior to beginning the program, and a follow-up scan immediately after the program finishes. The other group (Control group) will be recruited from campus and will only receive educational information about alcohol use. They will partake in a baseline and follow-up fMRI scan on the same time schedule as the BI group. Measures of emotional functioning, drinking motives, alcohol consumption, and alcohol-related problems will be measured at each scan, as well as 3 and 6 months post-scan. The research specific aims are: 1) examine sex differences in binge drinking risk factors, motivations, and underlying neural correlates at baseline in collegiate bing drinkers; 2) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking; and 3) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking. I will accomplish these research and training goals through close mentorship from a team with expertise in these content areas, didactic coursework, and directed readings.

 这个K 01指导研究科学家奖将支持我建立一个独立的研究生涯，使用神经影像学来调查个体差异在酒精使用障碍风险和治疗结果中的作用。该应用程序的培训部分建立在我的神经科学和神经影像学背景的基础上，这展示了强大的技术能力，并为研究物质风险的精神病理学提供了坚实的基础科学基础。为了实现完全的研究独立性，我确定了四个关键培训目标：1）获得临床经验，以了解酒精使用障碍及其治疗的各个方面; 2获得性别差异和成瘾领域的专业知识; 3）获得统计方法学方面的高级培训;和4）增加有关简短干预措施和动机访谈技术的知识。我将在密歇根大学精神病学系副教授Maureen Walton博士和密歇根大学精神病学系助理教授玛丽Heitzeg博士的指导下完成这一过程。一个精心挑选的顾问小组将提供额外的指导和培训。 拟议的K 01项目将在密歇根大学成瘾研究中心（UMARC）精神病学系内进行，这是一个多学科研究中心，由NIAAA，NIDA，NIMH和其他一些外部资金来源资助，以解决成瘾问题，其原因及其补救措施。其他80个药物滥用研究项目活跃在密歇根大学校园，UMARC教师与这些其他科学家互动和合作。该大学的功能磁共振成像实验室也是一个协作，跨学科的设施，由许多部门的研究人员使用，包括精神病学，心理学，生物医学工程和放射学，仅举几例。密歇根大学充满活力的研究环境培养了一批不断扩大的神经影像学研究人员，其中包括Heitzeg博士，他是密歇根纵向研究神经影像学部门的负责人8年，并因其在发育神经影像学和成瘾方面的工作而获得NIDA早期职业研究者奖。 研究部分的重点是确定男性和女性大学酗酒者之间在与酒精使用障碍风险相关的神经区域（冲动控制、情绪处理和酒精线索反应性）是否存在差异，以及这些区域在短暂干预后如何变化。有大量的行为证据表明，风险轨迹的差异，如女性往往得分较高的措施，负面影响和男性往往得分较高的措施冲动。这可能会延伸到年轻的成年人，当狂饮和这种行为产生的负面后果成为问题。此外，简短的干预措施已被证明是有效的大学狂饮者，与一些混合的结果，男性和女性的成功率。性别差异如何调节成瘾的神经生物学尚未得到充分研究;对这些差异进行更仔细的检查将有利于制定有针对性的预防和干预计划。 在这里，功能磁共振成像（fMRI）将在两组酗酒的大学生之间的年龄在18- 20岁，在每个组中的男性和女性人数相等（n=100）进行。其中一组（BI组）将从密歇根大学大学健康服务BASICS计划（针对大学生的简短酒精干预计划）中招募，并将在开始该计划之前进行基线fMRI扫描，并在计划结束后立即进行后续扫描。另一组（对照组）将从校园招募，只接受有关酒精使用的教育信息。他们将在与BI组相同的时间表上参与基线和随访fMRI扫描。在每次扫描时以及扫描后3个月和6个月测量情绪功能，饮酒动机，饮酒量和酒精相关问题。研究的具体目标是：1）研究性别差异的酗酒危险因素，动机，和潜在的神经相关性在基线的大学冰饮酒者; 2）表征的性别差异的神经机制的变化基本的短暂干预酗酒;和3）表征的性别差异的神经机制的变化基本的短暂干预酗酒。 我将通过在这些内容领域，教学课程和指导阅读的专业知识团队的密切指导来完成这些研究和培训目标。