Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye

生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱

基本信息

  • 批准号:
    10704485
  • 负责人:
  • 金额:
    $ 193.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-30 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY – Overall. This application proposes the founding of a Tissue Mapping Center (TMC) for the human eye and pancreas within the Human BioMolecular Atlas Program (HuBMAP). The mission of the proposed TMC is to build a platform of integrated technologies for imaging and molecular analysis that enables the construction of comprehensive 3-dimensional molecular atlases of human eye and pancreas. This TMC will leverage the unique resources of the Mass Spectrometry Research Center and the National Research Resource for Imaging Mass Spectrometry at Vanderbilt University, the world-class clinical environment of the Vanderbilt University Medical Center, the distinguished expertise of Organ Specific Project team leaders in their respective fields and their vast experience in organ procurement and management, and the advanced biocomputational infrastructure available to the TMC through the Data Analysis Core laboratories at Vanderbilt University and the Delft University of Technology, Netherlands to create a capability to molecularly characterize human tissues in 3-dimensions at a level of understanding unrivaled by current technologies. The innovative aspects of the proposed TMC are (1) the integration of imaging mass spectrometry, co-detection by indexing (CODEX), stained microscopy, and autofluorescence microscopy into 3-dimensional molecular atlases, (2) whole organ imaging of the eye, and (3) multi-organ atlases from the same donors through a proposed collaboration with the currently funded University of Florida TMC. The application of the proposed platform to organ-specific projects in pancreas and eye will provide a new paradigm of understanding the normal state of these organs across vast scales, both molecular (e.g., lipids, metabolites, and proteins) and spatial (e.g., whole organs to single cells). Furthermore, the involvement of these organs in diabetes, along with organs currently funded by HuBMAP such as kidney and vasculature, will lay an important foundation for future studies striving to understand the progression of diabetes. As a HuBMAP participant, the molecular atlases produced by this TMC will be disseminated to collaborators to generate new hypotheses regarding the function of these important organ systems, enabling new insight into human health and disease. This multidisciplinary effort requires the creation and integration of three capabilities to 1) procure and manage human tissue specimens, 2) determine and mitigate non-biological pre-analytical factors, and 3) acquire, process, and disseminate multimodal 3-dimensional imaging and large-scale omics data.
项目总结-总体。本申请建议建立组织绘图中心(TMC)。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Overcoming selection bias in synthetic lethality prediction.
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RICHARD M CAPRIOLI其他文献

RICHARD M CAPRIOLI的其他文献

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{{ truncateString('RICHARD M CAPRIOLI', 18)}}的其他基金

Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human Kidney
范德比尔特大学生物分子多模态成像中心进行人体肾脏 3 维绘图
  • 批准号:
    10701827
  • 财政年份:
    2022
  • 资助金额:
    $ 193.79万
  • 项目类别:
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human Kidney
范德比尔特大学生物分子多模态成像中心进行人体肾脏 3 维绘图
  • 批准号:
    10530865
  • 财政年份:
    2022
  • 资助金额:
    $ 193.79万
  • 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
  • 批准号:
    10480791
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:
Coordination Core
协调核心
  • 批准号:
    10480793
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
  • 批准号:
    10254369
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:
Coordination Core
协调核心
  • 批准号:
    10254370
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:
Coordination Core
协调核心
  • 批准号:
    10117949
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
  • 批准号:
    10117948
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
  • 批准号:
    10661915
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:
Coordination Core
协调核心
  • 批准号:
    10704486
  • 财政年份:
    2020
  • 资助金额:
    $ 193.79万
  • 项目类别:

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  • 批准号:
    9212055
  • 财政年份:
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  • 资助金额:
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  • 项目类别:
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