Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
基本信息
- 批准号:10704485
- 负责人:
- 金额:$ 193.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAcademic Medical CentersAlabamaApplications GrantsAtlasesCellsClinicalClinical DataCollaborationsCollectionCommunitiesDataData AnalysesData SetDetectionDevelopmentDiabetes MellitusDimensionsDiseaseEnsureEnvironmentExcisionEyeFloridaFoundationsFreezingFundingFutureGenerationsHealthHistologicHistologyHumanHuman BioMolecular Atlas ProgramImageImaging technologyImmunofluorescence ImmunologicInfrastructureKidneyLaboratoriesLipidsMass Spectrum AnalysisMedical ImagingMedical centerMicroscopyMissionModalityMolecularMolecular AnalysisMonitorMultimodal ImagingNational Center for Research ResourcesNetherlandsNormal tissue morphologyOperative Surgical ProceduresOptical Coherence TomographyOrganOrgan ProcurementsPancreasParticipantPerformancePhysiciansPositioning AttributePreparationProceduresProcessProteinsProteomicsQuality ControlReproducibilityResearchResearch PersonnelResourcesSamplingScientistSourceSpecimenStainsStandardizationSurfaceSystemTechnical ExpertiseTechniquesTechnologyTestingTissuesUnited States National Institutes of HealthUniversitiesbiocomputingbody systemcell typechemical fixationcomputing resourcesdata acquisitiondata integrationex vivo imagingexperiencehuman tissueimaging facilitiesimaging modalityin vivoindexinginnovationinsightmass spectrometric imagingmembermetabolomicsmultidisciplinarymultimodalitypreservationprogramsquality assurancesingle-cell RNA sequencingtissue mapping
项目摘要
PROJECT SUMMARY – Overall. This application proposes the founding of a Tissue Mapping Center (TMC)
for the human eye and pancreas within the Human BioMolecular Atlas Program (HuBMAP). The mission of the
proposed TMC is to build a platform of integrated technologies for imaging and molecular analysis that enables
the construction of comprehensive 3-dimensional molecular atlases of human eye and pancreas. This TMC will
leverage the unique resources of the Mass Spectrometry Research Center and the National Research
Resource for Imaging Mass Spectrometry at Vanderbilt University, the world-class clinical environment of the
Vanderbilt University Medical Center, the distinguished expertise of Organ Specific Project team leaders in
their respective fields and their vast experience in organ procurement and management, and the advanced
biocomputational infrastructure available to the TMC through the Data Analysis Core laboratories at Vanderbilt
University and the Delft University of Technology, Netherlands to create a capability to molecularly
characterize human tissues in 3-dimensions at a level of understanding unrivaled by current technologies. The
innovative aspects of the proposed TMC are (1) the integration of imaging mass spectrometry, co-detection by
indexing (CODEX), stained microscopy, and autofluorescence microscopy into 3-dimensional molecular
atlases, (2) whole organ imaging of the eye, and (3) multi-organ atlases from the same donors through a
proposed collaboration with the currently funded University of Florida TMC. The application of the proposed
platform to organ-specific projects in pancreas and eye will provide a new paradigm of understanding the
normal state of these organs across vast scales, both molecular (e.g., lipids, metabolites, and proteins) and
spatial (e.g., whole organs to single cells). Furthermore, the involvement of these organs in diabetes, along
with organs currently funded by HuBMAP such as kidney and vasculature, will lay an important foundation for
future studies striving to understand the progression of diabetes. As a HuBMAP participant, the molecular
atlases produced by this TMC will be disseminated to collaborators to generate new hypotheses regarding the
function of these important organ systems, enabling new insight into human health and disease. This
multidisciplinary effort requires the creation and integration of three capabilities to 1) procure and manage
human tissue specimens, 2) determine and mitigate non-biological pre-analytical factors, and 3) acquire,
process, and disseminate multimodal 3-dimensional imaging and large-scale omics data.
项目总结-总体。该申请提出建立组织映射中心(TMC)
人类生物分子图谱计划(HuBMAP)中的人眼和胰腺。联合国的使命
拟议的TMC是建立一个成像和分子分析集成技术平台,
人眼和胰腺三维分子图谱的构建。该TMC将
利用质谱研究中心和国家研究中心的独特资源,
范德比尔特大学的成像质谱资源,世界一流的临床环境,
范德比尔特大学医学中心,器官特异性项目团队领导的杰出专业知识,
他们各自的领域和丰富的经验,在器官采购和管理,和先进的
通过位于范德比尔特的数据分析核心实验室,TMC可以使用生物计算基础设施
大学和荷兰德尔夫特理工大学合作,
以当前技术无法比拟的理解水平在三维中表征人体组织。的
所提出的TMC的创新方面是(1)成像质谱的集成,
索引(CODEX),染色显微镜和自体荧光显微镜到三维分子
图集,(2)眼睛的整个器官成像,以及(3)通过
建议与目前资助的佛罗里达大学TMC合作。建议的应用
胰腺和眼睛器官特异性项目的平台将提供一个新的范式,
这些器官在大尺度上的正常状态,分子(例如,脂质、代谢物和蛋白质)和
空间的(例如,整个器官到单个细胞)。此外,这些器官参与糖尿病,沿着
目前由HuBMAP资助的器官,如肾脏和血管,将为
未来的研究努力了解糖尿病的进展。作为HuBMAP参与者,
该TMC制作的地图集将分发给合作者,以产生关于
这些重要器官系统的功能,使新的洞察人类健康和疾病。这
多学科的努力需要建立和整合三种能力:1)采购和管理
人体组织样本,2)确定和减轻非生物预分析因素,以及3)获取,
处理和传播多模式三维成像和大规模组学数据。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Overcoming selection bias in synthetic lethality prediction.
- DOI:10.1093/bioinformatics/btac523
- 发表时间:2022-09-15
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
RICHARD M CAPRIOLI其他文献
RICHARD M CAPRIOLI的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('RICHARD M CAPRIOLI', 18)}}的其他基金
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human Kidney
范德比尔特大学生物分子多模态成像中心进行人体肾脏 3 维绘图
- 批准号:
10701827 - 财政年份:2022
- 资助金额:
$ 193.79万 - 项目类别:
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human Kidney
范德比尔特大学生物分子多模态成像中心进行人体肾脏 3 维绘图
- 批准号:
10530865 - 财政年份:2022
- 资助金额:
$ 193.79万 - 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
- 批准号:
10480791 - 财政年份:2020
- 资助金额:
$ 193.79万 - 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
- 批准号:
10254369 - 财政年份:2020
- 资助金额:
$ 193.79万 - 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
- 批准号:
10117948 - 财政年份:2020
- 资助金额:
$ 193.79万 - 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
- 批准号:
10661915 - 财政年份:2020
- 资助金额:
$ 193.79万 - 项目类别:
Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye
生物分子多模态成像中心:人类胰腺和眼睛的 3 维组织图谱
- 批准号:
10428085 - 财政年份:2020
- 资助金额:
$ 193.79万 - 项目类别:
相似海外基金
Building a Systems Approach to Community Health and Health Equity for Academic Medical Centers
为学术医疗中心建立社区健康和健康公平的系统方法
- 批准号:
9348616 - 财政年份:2016
- 资助金额:
$ 193.79万 - 项目类别:
Building a Systems Approach to Community Health and Health Equity for Academic Medical Centers
为学术医疗中心建立社区健康和健康公平的系统方法
- 批准号:
9212055 - 财政年份:2016
- 资助金额:
$ 193.79万 - 项目类别:
A CONFERENCE ON THE 'CRISIS' OF ACADEMIC MEDICAL CENTERS
关于学术医疗中心“危机”的会议
- 批准号:
6335654 - 财政年份:2000
- 资助金额:
$ 193.79万 - 项目类别: