Opportunities for Pathology Trainees in Cancer Research

癌症研究病理学实习生的机会

• 批准号: 10704553
• 负责人: Charles G Eberhart
• 金额: $ 11.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-21 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704553
• 关键词: Pathology; anticancer research

Project Summary/Abstract Pathologists are uniquely positioned to contribute to cancer research. Their familiarity with disease classifications and pathogenesis, physical manifestations of tumors in tissue, and clinical challenges in cancer care mean that these investigators can provide important perspectives in developing experimental models that recapitulate key aspects of human disease. The Opportunities for Pathology Trainees In Cancer research (OPTIC) program at the Johns Hopkins University School of Medicine (JHUSOM) supports postdoctoral trainees developing research-oriented careers in cancer pathology and is geared towards preparing them for leadership roles in academic pathology and laboratory-based cancer research. Over the first funding period, the mandate of the OPTIC program has been to attract and recruit the brightest pathology trainees interested in cancer research; to pair them with faculty mentors representing the remarkable breadth and diversity of cancer research at JHUSOM; to protect their time for an immersive experience in the research laboratory; and to involve them in a unique and program-specific educational curriculum. With four postdoctoral trainees each year, the program is overseen by internal and external oversight committees consisting of highly successful academic pathologists in cancer research. Fellows select a research mentor from participating faculty – a stellar group recruited from the full spectrum of cancer research fields at the institution. All are accomplished investigators with an expertise in experimental cancer research and strong track records of laboratory-based mentorship. In addition to pursuing a rigorous research program, trainees participate in program-specific didactics and workshops to develop skills for their independent careers, and enroll in other course work tailored to their individual interests and chosen to complement their previous experiences. Fellows create an Independent Development Plan with their mentor, each trainee convenes meetings of an Individual Progress Committee, members of which provide feedback on their progress, recommend specific near-term research goals and training activities, and are generally be available as career mentors and advocates. Fellows leave the program poised for transitions to mentored and independent faculty positions in academic pathology departments and fully prepared to conduct high impact cancer research.

项目总结/摘要 病理学家在为癌症研究做出贡献方面具有独特的地位。他们对疾病分类的熟悉程度 和发病机制、组织中肿瘤的物理表现以及癌症护理中的临床挑战意味着， 这些研究人员可以在开发实验模型方面提供重要的观点， 人类疾病的各个方面。癌症研究病理学培训生的机会（OPTIC）计划 约翰霍普金斯大学医学院（JHUSOM）的博士后培训生 在癌症病理学研究为导向的职业生涯，并准备他们的领导作用， 学术病理学和实验室癌症研究。在第一个供资期间， OPTIC计划一直在吸引和招募对癌症研究感兴趣的最聪明的病理学学员; 将他们与代表JHUSOM癌症研究的显著广度和多样性的教师导师配对; 保护他们在研究实验室沉浸式体验的时间;并让他们参与独特的， 具体的教育课程。每年有四名博士后学员，该计划由 内部和外部监督委员会，由非常成功的癌症学术病理学家组成 research.研究员从参与的教师中选择一位研究导师--这是一个从全世界招募的明星团队。 该机构的癌症研究领域的光谱。他们都是有成就的调查员， 实验性癌症研究和基于实验室的指导的良好记录。除了追求 一个严格的研究计划，学员参加特定计划的教学和研讨会，以发展技能 为他们的独立职业，并报名参加其他课程的工作，适合他们的个人利益，并选择 补充他们以前的经验。研究员与他们的导师一起制定独立发展计划， 每个受训者召开个人进步委员会会议，委员会成员提供以下反馈： 他们的进展，建议具体的近期研究目标和培训活动，一般是 作为职业导师和倡导者。研究员离开该计划准备过渡到指导和 在学术病理学部门的独立教师职位，并充分准备进行高影响 癌症研究。

项目成果

Unresectable Metastatic Testicular Germ Cell Tumor With Low-grade Neuroglial Neoplasm, Stable After Radiation and Chemotherapy.

不可切除的转移性睾丸生殖细胞肿瘤，伴有低度神经胶质肿瘤，放疗和化疗后稳定。

• DOI: 10.1097/pai.0000000000001081
• 发表时间: 2023
• 期刊: Applied immunohistochemistry & molecular morphology : AIMM
• 作者: Tabibi,Seena;Kamanda,Sonia;Llosa,Nicolas;Pratilas,ChristineA;Duncan,BrynnB;Esteves,RodrigoSalgado;Matoso,Andres
• 通讯作者: Matoso,Andres

Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum.

• DOI: 10.1097/pas.0000000000001111
• 发表时间: 2018-09
• 期刊: The American journal of surgical pathology
• 作者: Palsgrove DN;Li Y;Pratilas CA;Lin MT;Pallavajjalla A;Gocke C;De Marzo AM;Matoso A;Netto GJ;Epstein JI;Argani P
• 通讯作者: Argani P

Interleukin-36γ-producing macrophages drive IL-17-mediated fibrosis.

• DOI: 10.1126/sciimmunol.aax4783
• 发表时间: 2019-10-11
• 期刊: Science immunology
• 影响因子: 24.8
• 作者: Sommerfeld SD;Cherry C;Schwab RM;Chung L;Maestas DR Jr;Laffont P;Stein JE;Tam A;Ganguly S;Housseau F;Taube JM;Pardoll DM;Cahan P;Elisseeff JH
• 通讯作者: Elisseeff JH

Analysis of Intestinal Metaplasia Without Dysplasia in the Urinary Bladder Reveal Only Rare Mutations Associated With Colorectal Adenocarcinoma.

• DOI: 10.1097/pai.0000000000000812
• 发表时间: 2020
• 期刊: Applied immunohistochemistry & molecular morphology : AIMM

Aberrant p53 Expression in Gastric Biopsies and Resection Specimens Following Neoadjuvant Chemoradiation: A Diagnostic Pitfall.

• DOI: 10.1177/10668969231157304
• 发表时间: 2023-12
• 期刊: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
• 影响因子: 1.2
• 作者: Hutchings, Danielle A.;Salimian, Kevan J.;Waters, Kevin M.;Birkness-Gartman, Jacqueline E.;Voltaggio, Lysandra;Assarzadegan, Naziheh;Huang, Jialing L.;Lin, Ming-Tseh;Singhi, Aatur D.;Montgomery, Elizabeth A.
• 通讯作者: Montgomery, Elizabeth A.