Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in India

利用自然实验来估计血糖对印度痴呆症和认知的因果影响

基本信息

  • 批准号:
    10703989
  • 负责人:
  • 金额:
    $ 43.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-09-15 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary The global burden of dementia is growing substantially as low- and middle-income countries (LMICs) undergo demographic transitions resulting in rapidly aging populations. Understanding the factors that affect dementia prevalence in LMICs such as India and identifying cost-effective interventions that may curb the onset of dementia and cognitive decline is thus an important public health and policy priority. Evidence from several studies indicates that diabetes increases the risk of developing cognitive impairment and dementia, but few studies have used population-representative data from LMICs experiencing rapidly increasing diabetes rates. Furthermore, interventions that seek to change diets and reduce diabetes risk by targeting individuals directly have had mixed success and are costly to implement at scale. In contrast, policy-level solutions such as sugar-sweetened beverage taxes or regulation of food supply (e.g., caps on added sugars) have the potential to influence dietary patterns at scale, especially in low-income settings where resources are scarce. There is a vital need to identify large-scale policy solutions for reducing diabetes and dementia in LMICs. This project will use population-representative data on dementia in India to accomplish three aims. First, we will study the association between dementia and diabetes, a known risk factor, in a low-income setting with a high prevalence of diabetes. We will also study heterogeneity in this relationship by dietary practice and by sex. Second, we will evaluate a scalable public health intervention that may reduce HbA1c levels and diabetes rates: the delivery of parboiled rice through the Indian government’s Public Distribution System, which provides roughly one-third of the total grain consumed in the country. To accomplish this goal, we will leverage detailed data on the quasi-random distribution of parboiled rice in Kerala, a state with high rice consumption, as well as data on HbA1c and blood glucose from three data sources including the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD). Finally, we will leverage the quasi-random delivery of parboiled rice to study the causal effect of diabetes on dementia and cognitive decline using an instrumental variables approach.
项目总结

项目成果

期刊论文数量(0)
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Jinkook Lee其他文献

Jinkook Lee的其他文献

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{{ truncateString('Jinkook Lee', 18)}}的其他基金

Integrating Information about Aging Surveys
整合有关老龄化调查的信息
  • 批准号:
    10059080
  • 财政年份:
    2020
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Surveys in India (LASI)
印度纵向老龄化调查 (LASI) 痴呆症统一诊断评估 (DAD)
  • 批准号:
    10267745
  • 财政年份:
    2015
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study in India (LASI)
印度纵向老龄化研究 (LASI) 痴呆症统一诊断评估 (DAD)
  • 批准号:
    9307615
  • 财政年份:
    2015
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Surveys in India (LASI)
印度纵向老龄化调查 (LASI) 痴呆症统一诊断评估 (DAD)
  • 批准号:
    10449280
  • 财政年份:
    2015
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)
印度纵向老龄化研究 (LASI) 痴呆症统一诊断评估 (DAD)
  • 批准号:
    9301438
  • 财政年份:
    2015
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD): Epigenomic Assays
印度纵向衰老研究痴呆症统一诊断评估 (LASI-DAD):表观基因组分析
  • 批准号:
    10848802
  • 财政年份:
    2015
  • 资助金额:
    $ 43.93万
  • 项目类别:
Archiving & Creating User Friendly Data: the Longitudinal Aging Survey in India
归档
  • 批准号:
    8370785
  • 财政年份:
    2012
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonization of Cross-national Studies of aging to the Health & Retirement Study
老龄化与健康跨国研究的协调
  • 批准号:
    8721295
  • 财政年份:
    2010
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonization of Cross-national Studies of aging to the Health & Retirement Study
老龄化与健康跨国研究的协调
  • 批准号:
    8320898
  • 财政年份:
    2010
  • 资助金额:
    $ 43.93万
  • 项目类别:
Harmonization of Cross-national Studies of aging to the Health & Retirement Study
老龄化与健康跨国研究的协调
  • 批准号:
    8136503
  • 财政年份:
    2010
  • 资助金额:
    $ 43.93万
  • 项目类别:

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