ECOG-ACRIN NCORP Research Base

ECOG-ACRIN NCORP研究基地

• 批准号: 10704024
• 负责人: Peter J ODwyer
• 金额: $ 515.49万
• 依托单位: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704024
• 关键词: Abbreviations; Adolescent and Young Adult; Adopted; Advocacy; Advocate; American College of Radiology Imaging Network; Area; Attention; Behavioral; Biological Markers; Biostatistical Methods; Breast Magnetic Resonance Imaging; Cancer Biology; Cancer Burden; Cancer Control; Cancer Prevention Trial; Cancer Research Network; Cancer Survivorship; Cardiotoxicity; Caring; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Clinical Oncology Program; Complex; Continuity of Patient Care; Data Science; Dedications; Development; Diagnosis; Discipline; Disparity; Early Diagnosis; Eastern Cooperative Oncology Group; Elderly; Ensure; Fostering; Funding; Goals; Image; Immunooncology; Influentials; Infrastructure; Institution; International; Intervention; Laboratories; Leadership; Malignant Neoplasms; Measurement; Medical; Minority; Mission; Monitor; National Cancer Institute; National Clinical Trials Network; Nurses; Participant; Patient Outcomes Assessments; Patients; Physicians; Population; Population Heterogeneity; Populations at Risk; Postdoctoral Fellow; Prevention; Prevention strategy; Prevention trial; Primary Prevention; Process; Provider; Quality of life; Reporting; Research; Research Design; Research Personnel; Research Support; Resources; Risk Reduction; Science; Scientist; Screening for cancer; Secondary Prevention; Sexual and Gender Minorities; Site; Symptoms; System; Therapeutic Trials; Tissue imaging; Tissues; Translating; Translational Research; Underrepresented Minority; Underserved Population; Work; advanced disease; anticancer research; base; biobank; biomarker driven; cancer care; cancer clinical trial; cancer prevention; cancer therapy; care delivery; career development; clinical translation; community engagement; control trial; eHealth; ethnic minority; experience; financial toxicity; gender minority; health equity; health related quality of life; high risk; high risk population; imaging biomarker; imaging modality; improved; individualized prevention; innovation; interest; member; minority engagement; multidisciplinary; novel; novel marker; oncology program; operation; overtreatment; personalized approach; physical symptom; precision oncology; prevent; programs; psychological symptom; racial minority; research study; risk mitigation; rural dwellers; screening; support network; survivorship; symptom science; team-based care; tissue biomarkers

Project Summary The ECOG-ACRIN Cancer Research Group (EA) is dedicated to decreasing the burden of cancer. EA is a vibrant member of the National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP), focused on practice-changing clinical and translational research across the cancer care continuum from prevention and early detection, through the management of advanced disease and its impact. As an NCORP Research Base, EA has engaged community providers and researchers to develop a robust research portfolio that spans Cancer Prevention, Cancer Control, and Cancer Care Delivery, aligned with the overall scientific themes of precision oncology, immuno-oncology, reducing overdiagnosis and overtreatment, and leveraging novel biomarker platforms. Cancer control trials examine and intervene on challenges associated with cancer and treatment-related symptoms and concerns. EA's portfolio of therapeutic trials yield opportunities to apply patient-reported outcomes measurement science to quantify health-related quality of life, symptoms, and domains most relevant to patients in the context of evolving treatment paradigms. Behavioral and biomarker-driven symptom interventions aim to improve quality of life and cancer survivorship. Cardiotoxicity research aims to mitigate risk through quantifying cardiotoxicity associated with treatment, identifying groups at risk, and advancing interventions to reduce risk. Prevention trials embrace the NCI's broad definition of prevention to include primary prevention, cancer screening, and secondary prevention and aim to identify high risk groups for precision prevention strategies. Cancer Care Delivery Research (CCDR) examines the complex interactions between patient, provider, and system factors that influence care, and adapts and evaluates interventions in heterogenous community oncology practices. Health equity research permeates EA science through embedding disparities-related research questions that span EA activities, adopting a broad view of underserved populations including adolescents and young adults, the elderly, racial and ethnic minorities, sexual and gender minorities and rural residents. Key collaborations with community-based oncology programs will ensure access to EA NCTN and NCORP trials in communities where patients receive their care. EA provides access to existing NCI-funded resources and a network of >10000 physicians, scientists, nurses, research associates (RAs), statisticians, biomedical information technologists, and patient advocates across approximately 600 institutions and organizations. EA has provided scientific leadership in the NCORP community through advancing rigorous, practice-changing clinical trials and translational research in cancer control, prevention and care delivery and is well poised to continue to support the NCI's mission to engage community-based diverse populations in cancer research.

项目摘要 ECOG-ACRIN癌症研究小组（EA）致力于减轻癌症的负担。 ea 是国家临床试验网络（NCTN）和NCI社区肿瘤学的充满活力的成员 研究计划（NCORP），专注于改变实践的临床和翻译研究 通过管理先进的预防和早期检测的癌症护理连续性 疾病及其影响。作为NCORP研究基础，EA与社区提供商和 研究人员开发出强大的研究组合，涵盖预防癌症，癌症控制和 癌症护理分娩，与精确肿瘤学，免疫肿瘤学的总体科学主题保持一致， 减少过度诊断和过度治疗，并利用新型的生物标志物平台。癌症控制 试验检查并干预与癌症和治疗相关症状相关的挑战以及 关注。 EA的治疗试验组合产生了应用患者报告结果的机会 测量科学以量化与健康相关的生活质量，症状和领域最相关的领域 患者在不断发展的治疗范例的情况下。行为和生物标志物驱动症状 干预措施旨在改善生活质量和癌症生存。心脏毒性研究的目的是 通过量化与治疗相关的心脏毒性，识别有风险的群体以及 推进干预措施以降低风险。预防试验涵盖了NCI对预防的广泛定义 包括主要预防，癌症筛查和次要预防，旨在确定高风险 精确预防策略的组。癌症护理分娩研究（CCDR）检查了 患者，提供者和影响护理的系统因素之间的复杂互动，适应和适应 评估异源社区肿瘤学实践的干预措施。健康公平研究 通过嵌入EA活动的与差异相关的研究问题渗透到EA科学， 对包括青少年和年轻人，老年人在内的人口不足的人口进行广泛的看法 种族和少数民族，性和性别少数民族以及农村居民。关键合作 基于社区的肿瘤学计划将确保在社区中访问EA NCTN和NCORP试验 患者得到护理的地方。 EA提供对现有NCI资助的资源和网络的访问 > 10000名医师，科学家，护士，研究助理（RAS），统计学家，生物医学信息 技术人员以及大约600个机构和组织的患者拥护者。 EA有 通过推进严格的，改变实践的方式，在NCORP社区中提供了科学领导 癌症控制，预防和护理提供的临床试验和转化研究，并保持良好 继续支持NCI的使命，使社区的多元化人群参与癌症 研究。