Developmental Research Program

项目概要-药物研究中心（DRP） UPMC希尔曼癌症中心（HCC）头颈部发展研究计划（DRP） (HN)SPORE旨在资助和促进头部和颈部的创新试点项目 鳞状细胞癌（HNSCC）。总体目标是降低HNSCC的发病率和死亡率 通过促进预防和早期发现领域的新研究;肿瘤发生机制 和治疗耐药性;预测和预后生物标志物;以及新的目标和方法， 疗法为了实现这一目标，我们将建立在我们成功的计划，在目前的资金周期， 支持了15个奖项，随后促成了42篇出版物、9项外部赠款、3项专利、6项 发明和2项临床试验，投资回报率为27.2（即，每投入一美元， 返回）。每半年，我们将广泛征求新的HNSCC研究人员的建议，以及 来自HNSCC的资深研究人员，他们有着高度创新的想法。内部和外部的成员 将鼓励咨询委员会在HCC HN SPORE之外寻找可以任职的调查人员 作为潜在的合作者。此外，我们还与埃默里大学、约翰霍普金斯 大学、霍华德大学和梅哈里大学（后两所指定的历史黑人大学）在一个 努力扩大申请人的多样性，并对最新的SPORE PAR-20-305做出反应， 每年为URM项目负责人颁发一个特定的额外DRP奖。 提交的最有价值的提案将根据NIH风格的两级审查进行选择，以确保 严格和没有偏见和支持将来自SPORE基金和机构承诺。DRP 获奖者新到HNSCC将被分配一个经验丰富的导师提供指导和融入 孢子。所有DRP获奖者将每年报告其项目的进展情况， 取得重大研究进展的机构可申请第二年的竞争性续期。如果有需要， 具有重大转化影响潜力的特殊试点项目可以提升为完整的SPORE项目。 事实上，在这次更新的三个完整的SPORE项目中，有两个来自DRP试点。

PROJECT SUMMARY – DEVELOPMENTAL RESEARCH PROGRAM (DRP) The Developmental Research Program (DRP) of the UPMC Hillman Cancer Center (HCC) Head and Neck (HN) SPORE seeks to fund and facilitate translationally driven, innovative pilot projects in head and neck squamous cell carcinoma (HNSCC). The overarching goal is to decrease HNSCC morbidity and mortality through stimulating new research in the areas of prevention and early detection; mechanisms of tumorigenesis and therapeutic resistance; predictive and prognostic biomarkers; and novel targets and approaches to therapy. To accomplish this goal, we will build on our successful program that, in this current funding cycle, supported 15 awards that subsequently contributed to 42 publications, 9 external grants, 3 patents, 6 inventions and 2 clinical trials, with a return on investment of 27.2 (ie. for every dollar invested 27.2 were returned). Biannually, we will widely solicit proposals from investigators new to HNSCC research as well as from established HNSCC investigators with highly innovative ideas. Members of the Internal and External Advisory Boards will be encouraged to identify investigators outside of the HCC HN SPORE who could serve as potential collaborators. In addition, we have established a partnership with Emory University, Johns Hopkins University, Howard University and Meharry – the latter two designated Historical Black Universities – in an effort to expand the diversity of the applicant pool and be responsive to the most recent SPORE PAR-20-305, with a specific additional DRP award annually for an URM project leader. The most meritorious proposals submitted will be selected based on an NIH-style two-tiered review to ensure rigor and absence of bias and support will come from both SPORE funds and institutional commitment. DRP awardees new to HNSCC will be assigned an experienced mentor to provide guidance and integration into the SPORE. All DRP awardees will report annually on the progress of their projects and those that demonstrate significant research progress will be eligible for competitive renewal for a second year. Should the need arise, exceptional pilots with potential for significant translational impact can be elevated to full SPORE projects. Indeed, two of the three full SPORE projects in this renewal came from DRP pilots.