The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

减去 俄亥俄州立大学(OSU)临床与翻译科学中心(CCTS)成立于2007年， 着眼于推进今天的发现，以改善所有人的健康。我们雇佣了一名全面的 通过高度的教育和职业发展来解决T1-T4科学的全方位问题的方法 训练有素的劳动力与强大的CTR资源系统相结合。我们在CTSA中发挥了领导作用 通过分享促进CTR的工具和方法；采用其他枢纽的创新；以及 全面参与CTSA联盟的活动(例如，多点试验)。我们还支持社区参与 解决我们社区最紧迫的健康问题的研究(例如，阿片类药物危机，新冠肺炎)。然而， 工作还在继续。因此，我们在俄亥俄州立大学/北卡罗来纳州立大学和俄亥俄州社区建立了独特的优势。我们有 利用我们在数据科学方面的战略投资、强大的资源环境和充满活力的CTR 社区以解决CTS方面的差距和障碍。我们现在将解决CTS的五个障碍，以改善 CTR的质量、效率和严格性：(1)需要提高效率和效力，以推进CTR和 确保将成果传播并落实到医疗保健中；2)教育和培训创新不 覆盖整个CTR员工队伍，导致CTS员工队伍不断减少且不够多样化，缺乏 推动CTR的知识和技能；3)不同利益攸关方在整个 研究生命周期；4)复杂数据集的增长需要将临床、环境和 研究数据，需要数据获取民主化，以促进数据公平；以及5)种族不公正， SDOH、我们组建的CTR团队以及对我们结果的解释都会影响健康差距。应用健康 公平和Deia框架到每一项活动，我们将追求五个目标：目标1：在 解决CTR面临的紧迫障碍的方法、途径和工具。目标2：支持培训和 CTS全体员工的职业发展。目标3：吸纳学术界和科学界的声音 学科、患者、社区和行业在整个科学生命周期中进行CTR和CTS 进程。目标4：部署一个可访问的、响应迅速的、集成的研究资源系统。目标5： 通过降低数据访问和计算资源的进入成本，实现信息资源的民主化。使用 为了致力于以指标为导向的决策，我们将通过应用RE- AIM框架，为未来7年的战略支点提供信息。这项建议重申了我们对 推进CTS并扩大我们与利益相关方的接触，以提高严谨、有效和相关性 CTR。我们将通过集中的CTS开发、分享和采用创新，以提高社区的CTR 我们为客户服务，为客户服务。这些资源、熟练的员工队伍和机构优势提供了灵活的 基金会，以促进对新出现的公共卫生问题的快速反应，并将确保公平的视角 适用于所有CTR，使任何人都不会落后于CTR的进步，以改善人类健康。

ABTRACT The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) was formed in 2007, with the vision to advance today’s discoveries to improve health for all. We employed a comprehensive approach to address the full spectrum of T1-T4 science via the education and career development of a highly trained workforce integrated with a robust system of CTR resources. We provided leadership in the CTSA Consortium through sharing of tools and methods to advance CTR; adopted innovations from other hubs; and fully engaged in CTSA Consortium activities (e.g., multisite trials). We also supported community engaged research addressing the most pressing health issues in our communities (e.g., opioid crisis, COVID-19). Yet, work remains. Thus, we build upon unique strengths at OSU/NCH and in Ohio’s communities. We have leveraged our strategic investment in data sciences, a robust environment of resources, and a vibrant CTR community to address CTS gaps and barriers. We will now address five CTS roadblocks to improve the quality, efficiency, and rigor of CTR: (1) need for improved efficiencies and effectiveness to advance CTR and ensure results are disseminated and implemented into healthcare; 2) education and training innovations do not reach the full CTR workforce, resulting in a declining and inadequately diverse CTS workforce, lacking the knowledge and skills to advance CTR; 3) limited authentic participation by diverse stakeholders across the research life cycle; 4) growth of complex datasets necessitates integration of clinical, environmental, and research data, with need for democratization of data accessibility to advance data equity; and 5) racial injustice, SDoH, the CTR teams we form, and interpretation of our results impact health disparities. Applying a health equity and DEIA framework to every activity, we will pursue five aims: Aim 1: Develop innovations in methods, approaches, and tools to address pressing roadblocks facing CTR. Aim 2: Support training and career development of the full CTS workforce. Aim 3: Engage voices from across academic and scientific disciplines, patients, communities, and industry to conduct CTR and CTS across the full lifecycle of the scientific process. Aim 4: Deploy an accessible, responsive, and integrated system of research resources. Aim 5: Democratize informatics resources by lowering the cost of entry for data access and computing resources. With a commitment to metric-driven decision-making, we will evaluate the impact of the CCTS by applying the RE- AIM framework to inform strategic pivots over the next 7 years. This proposal reaffirms our commitment to advance CTS and expands our engagement with stakeholders to increase rigorous, impactful, and relevant CTR. We will develop, share, and adopt innovations through focused CTS to enhance CTR for the communities we serve and those we engage. These resources, skilled workforce, and institutional strengths provide an agile foundation to facilitate rapid responses to emerging public health issues, and will ensure an equity lens is applied to all CTR so no one is left behind from the advances of CTR to improve human health.