Central Hub for Kidney Precision Medicine

摘要 KPMP Central Hub应用程序的首要目标是创建和支持协作 环境致力于促进参与者安全，科学严谨，患者参与，高道德 标准，包容性和跨学科团队科学，这是导致肾脏疾病重大进展所必需的。 精准医疗中心将协调KPMP招募中心、组织询问中心， 和机会池研究小组;参与更广泛的患者，临床和研究社区;以及 与肾脏组织图谱协调中心合作，安全、高效、透明地提供 向这些社区提供可查找、可扩展、可互操作和可重用的数据。我们经验丰富 多学科团队有助于建立所需的基础设施和功能生态系统， 启动和维护KPMP第一阶段。我们将在这一经验的基础上， 为实现下列具体目标提供技术、行政、业务和后勤支助：（1） 协调KPMP协议和程序的道德，安全和严格的实施;（2）支持 在严格的质量保证和质量控制下收集和分发高质量的数据和样本; (3)在KPMP内部建立、支持和维护一种包容、协作的文化， 重视研究参与者的贡献;（4）促进外部合作，促进新的 通过专门用于保持KPMP活力的资金机会池建立伙伴关系。

ABSTRACT The overarching objective of this KPMP Central Hub application is to create and support a collaborative environment committed to promoting participant safety, scientific rigor, patient engagement, high ethical standards, inclusivity, and the interdisciplinary team science necessary to result in major advances in kidney precision medicine. The Central Hub will coordinate the KPMP Recruitment Sites, Tissue Interrogation Sites, and Opportunity Pool research groups; engage the broader patient, clinical, and research communities; and partner with the Kidney Tissue Atlas Coordinating Center to securely, efficiently, and transparently deliver Findable, Accessible, Interoperable, and Reusable data to these communities. Our experienced multidisciplinary team was instrumental in building the infrastructure and functional ecosystem needed to launch and maintain the first phase of the KPMP. We will build on this experience to provide scientific, technical, administrative, operational, and logistical support to pursue the following specific aims: (1) coordinate ethical, safe, and rigorous implementation of KPMP protocols and procedures; (2) support the collection and distribution of high-quality data and samples with rigorous quality assurance and quality control; (3) build, support, and maintain an inclusive, collaborative culture within KPMP that continuously honors and values the contributions of study participants; and (4) foster external collaborations and catalyze new partnerships through an Opportunity Pool of funds dedicated to maintaining KPMP dynamism.