Central Hub for Kidney Precision Medicine

肾脏精准医学中心中心

• 批准号: 10706473
• 负责人: Jonathan Himmelfarb
• 金额: $ 430万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706473
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Atlases; Biometry; Budgets; Cells; Characteristics; Chronic Kidney Failure; Clinical; Clinical Data; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communities; Community Outreach; Complex; Data; Data Analyses; Data Set; Dedications; Diagnosis; Disease; Ecosystem; Education and Outreach; Ensure; Environment; Epidemiology; Ethics; FAIR principles; Fostering; Funding; Funding Agency; Goals; Human Resources; Image Analysis; Industry; Information Dissemination; Infrastructure; Institutional Review Boards; Kidney; Kidney Diseases; Knowledge; Laboratories; Lead; Leadership; Medicine; Metadata; Modeling; Molecular; Monitor; Multicenter Studies; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Nomenclature; Outcome; Participant; Pathology; Pathway interactions; Patients; Performance; Personnel Management; Phase; Philosophy; Prevention approach; Prevention strategy; Procedures; Protocols documentation; Public Health; Publications; Quality Control; Reporting; Research; Research Training; Role; Running; Sampling; Science; Scientific Advances and Accomplishments; Secure; Services; Site; Standardization; Structure; System; Systems Biology; Tissue atlas; Tissues; Work; biobank; biomedical informatics; collaborative environment; community engagement; data curation; data de-identification; data lake; data management; data modeling; data reuse; data sharing; disorder subtype; equity, diversity, and inclusion; experience; flexibility; improved; kidney biopsy; metadata standards; multidisciplinary; new therapeutic target; operation; participant enrollment; participant safety; patient engagement; patient stratification; precision medicine; programs; quality assurance; recruit; research study; satisfaction; software development; success; synergism; translational approach; web site; website development; working group

ABSTRACT The overarching objective of this KPMP Central Hub application is to create and support a collaborative environment committed to promoting participant safety, scientific rigor, patient engagement, high ethical standards, inclusivity, and the interdisciplinary team science necessary to result in major advances in kidney precision medicine. The Central Hub will coordinate the KPMP Recruitment Sites, Tissue Interrogation Sites, and Opportunity Pool research groups; engage the broader patient, clinical, and research communities; and partner with the Kidney Tissue Atlas Coordinating Center to securely, efficiently, and transparently deliver Findable, Accessible, Interoperable, and Reusable data to these communities. Our experienced multidisciplinary team was instrumental in building the infrastructure and functional ecosystem needed to launch and maintain the first phase of the KPMP. We will build on this experience to provide scientific, technical, administrative, operational, and logistical support to pursue the following specific aims: (1) coordinate ethical, safe, and rigorous implementation of KPMP protocols and procedures; (2) support the collection and distribution of high-quality data and samples with rigorous quality assurance and quality control; (3) build, support, and maintain an inclusive, collaborative culture within KPMP that continuously honors and values the contributions of study participants; and (4) foster external collaborations and catalyze new partnerships through an Opportunity Pool of funds dedicated to maintaining KPMP dynamism.

抽象的 KPMP Central Hub 应用程序的总体目标是创建和支持协作 致力于促进参与者安全、科学严谨、患者参与、高道德的环境 标准、包容性和跨学科团队科学是肾脏领域取得重大进展所必需的 精准医疗。中央中心将协调 KPMP 招募站点、组织审讯站点、 和机会库研究小组；让更广泛的患者、临床和研究团体参与进来；和 与肾脏组织图谱协调中心合作，安全、高效、透明地交付 这些社区可查找、可访问、可互操作和可重用的数据。我们经验丰富 多学科团队在建设所需的基础设施和功能生态系统方面发挥了重要作用 启动并维持 KPMP 第一阶段。我们将以此经验为基础，提供科学、 技术、行政、运营和后勤支持，以实现以下具体目标：(1) 协调 KPMP 协议和程序的道德、安全和严格实施； (2) 支持 通过严格的质量保证和质量控制收集和分发高质量的数据和样本； (3) 在 KPMP 内部建立、支持和维持包容、协作的文化，不断表彰和 重视研究参与者的贡献； (4) 促进外部合作并促进新的 通过致力于维持 KPMP 活力的机会池资金建立伙伴关系。