KPMP Kidney Mapping and Atlas Project (KMAP)

KPMP 肾脏绘图和图集项目 (KMAP)

• 批准号: 10492787
• 负责人: Jonathan Himmelfarb
• 金额: $ 196万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10492787
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Anatomy; Atlases; Bioinformatics; Biometry; Biopsy; Cells; Chronic Kidney Failure; Clinical; Collaborations; Communities; Community Outreach; Data; Data Analyses; Data Display; Data Set; Data Storage and Retrieval; Disease; Ecosystem; Ensure; Environment; FAIR principles; Funding; Future; Generations; Goals; Health; Human BioMolecular Atlas Program; Institution; Joints; Kidney; Kidney Diseases; Knowledge; Lead; Leadership; Maps; Metadata; Michigan; Molecular; Nephrology; Ontology; Participant; Pathologist; Pathology; Pathway interactions; Patients; Phase; Philosophy; Plant Roots; Process; Quality Control; Research; Research Personnel; Risk; Role; Route; Science; Services; Site; Stratification; Structure; Students; System; Systems Biology; Tissue atlas; Tissues; Universities; Washington; cloud based; collaborative environment; computerized data processing; data curation; data dissemination; data integration; data management; data modeling; data visualization; design; digital pathology; disorder subtype; diversity and equity; experience; flexibility; genomic data; indexing; interstitial; multimodal data; multimodality; nephrogenesis; new therapeutic target; outreach; participant safety; patient engagement; precision medicine; recruit; research study; response; skills; social; software development; structured data; success; tool; website development

ABSTRACT The overarching objective of the Kidney Mapping Atlas Project (KMAP) in response to the Kidney Tissue Atlas Coordinating Center (KTACC) application is to create and support the central data management, integration and dissemination platform for the Kidney Precision Medicine Project (KPMP). Our focus for the KMAP will be centered around the key values established by us in the first funding cycle of KPMP: a collaborative environment committed to promoting participant safety and engagement, scientific rigor, and outreach to the global renal research community anchored in a concept of interdisciplinary team science necessary to drive disruptive advances in kidney precision medicine. We plan to extend our highly experienced team successfully navigating the multiple inherent challenges during the startup phase of KPMP to address the key opportunities and challenges of the next phase of KPMP. To this end have assembled domain expertise in nephrology, nephro- and digitial pathology, anatomy, ontology, data curation, biostatistics, bioinformatics, renal systems biologists, data visualization, kidney user experience, website and software development. Our overarching principle will continue to be an uncompromising commitment to our patient partners co-leading our efforts and a sharp focus on rigorous QC and QC in tight coordination with the KPMP Central Hub, the Tissue Interrogation and Recruitment Sites and Opportunity pool awardees. We have pioneered a team science structure to advance a precision medicine approach to kidney disease with the development of the KPMP data management, integration and sharing framework strongly routed in FAIR principles. We share a common philosophy that our role is one of service, collaboration, and leadership with over 30 years of experience coordinating highly successful large-scale research studies into the molecular mechanism of kidney disease always supporting diversity, equity and inclusion in all aspects of renal precision medicine research. The KMAP will be led by Drs. Kretzler (University of Michigan) and Himmelfarb (University of Washington) with complementary expertise and an extensive track record in working together to lead clinical, translational and bench kidney precision medicine studies and will ensure the seamless integration of KMAP into the KPMP ecosystem. KMAP will serve its function via three main units. The KMAP Data Management Core (DMC) will be responsible to clean, harmonize, register, store and curate the diverse current and future KPMP data. The KMAP Data Analysis Hub (DAH) will integrate the multimodal data along the continuum of clinical, social-risk, spatial, ontological, digital-pathology and molecular data sets to identify key drivers of disease processes. Finally, the KMAP Data Visualization Hub (DAV) will develop, maintain and distribute a multi-dimensional atlas of kidney health and disease via a flexible computation environment. Tight integration of the KMAP efforts with HuBMAP, HCA and RBK/GUDMPA together with strong leadership skills of the PIs will ensure effective implementation across KPMP and the biomedical community at large.

摘要 肾组织图谱项目(KMAP)的总体目标 协调中心(KTACC)的应用是创建和支持中央数据管理、集成 和肾脏精准医学项目(KPMP)的传播平台。我们对KMAP的重点将是 围绕着我们在KPMP的第一个供资周期中建立的关键价值观：协作性 致力于促进参与者的安全和参与度、科学严谨性以及与 全球肾脏研究社区扎根于跨学科团队科学的概念，这是推动 肾脏精准医学的颠覆性进展。我们计划成功地扩大我们经验丰富的团队 在KPMP的启动阶段应对多重固有挑战，以抓住关键机遇 以及下一阶段淘汰管理计划所面临的挑战。为此，他们汇集了肾脏病领域的专业知识， 肾脏和数字病理学、解剖学、本体论、数据管理、生物统计学、生物信息学、肾脏系统 生物学家、数据可视化、肾脏用户体验、网站和软件开发。我们最重要的是 原则将继续是对我们的患者伙伴的不妥协承诺，共同领导我们的努力和 严格的QC和QC与KPMP中心中心、组织的紧密协调 审讯和招聘网站以及机会池获奖者。 我们开创了团队科学结构，通过以下方式推进肾脏疾病的精确医学方法 KPMP数据管理、整合和共享框架的开发在广交会上得到了大力支持 原则。我们有一个共同的理念，即我们的角色是服务、协作和领导 30多年协调非常成功的大规模分子研究研究的经验 肾脏疾病的机制始终支持肾脏精确度的各个方面的多样性、公平性和包容性 医学研究。KMAP将由Kretzler博士(密歇根大学)和Himmelfarb博士(大学)领导 拥有互补的专业知识和广泛的合作记录，共同领导 临床、转化和基准肾脏精准医学研究，并将确保无缝集成 将KMAP纳入KPMP生态系统。 KMAP将通过三个主要单位履行其职能。KMAP数据管理核心(DMC)将是 负责清理、协调、登记、存储和管理各种当前和未来的KPMP数据。这个 KMAP数据分析中心(DAH)将沿着临床、社会风险、 空间、本体论、数字病理学和分子数据集，以确定疾病过程的关键驱动因素。 最后，KMAP数据可视化中心(DAV)将开发、维护和分发多维 通过灵活的计算环境提供肾脏健康和疾病地图集。 KMAP努力与HuBMAP、HCA和RBK/GUDMPA紧密结合，并具有强大的领导力 绩效指标的技能将确保在KPMP和整个生物医学界有效实施。