Tissue Engineering and Regenerative Medicine Undergraduate Research Addressing Challenges in Kidney and Urologic Diseases

项目总结 这个为期5年的本科生暑期研究所迎接肾脏和泌尿外科疾病的挑战 (Kud)在维克森林再生医学研究所(WFIRM)，提供8个不同的队列 本科生每年暑期(2022-2027)利用10周的多学科研究机会 组织工程和再生医学(学期)战略，以应对与 预防和治疗肾脏和泌尿系统疾病。有兴趣解决的问题是 “漏水管道”对生物医学劳动力的多样性产生负面影响，我们关注的是参与 代表不足的少数群体、妇女和非传统学生--包括参加 研究和第一代学生有限的两年制和四年制大学。通过相伴的焦点 KUD研究和保健方面的差距，再加上技能发展和创新的研究课程 教育/职业持续性干预为学生参与者提供支持，我们希望：1)增强多样性 学生与教师和研究生导师的参与、学习和研究指导经验 在为期10周的现场培训期间及之后；2)增强学生的知识、职业意向和 特别是在Kud研究方面的长期坚持，以及在生物医学研究方面的广泛职业生涯；3)发展和 实施专业化的职业意向和认知评估方法；4)对职业生涯产生更大影响 社区；以及5)增加研究生、博士和MD/博士项目和职业的入学人数，重点放在 Term和Kud研究。这些目标将通过高度协调、有指导的跨学科来实现 暑期研究所结合实际和虚拟的研究活动，仪器 培训、教学内容、专业研讨会、研讨会和迷你课程 部门和中心以及其他资助的NIDDK R25项目，跨越生物伦理学，负责 研究、健康差距、口头和书面交流，以及为项目量身定做的教育和职业 发展感想和意向评估。所有学生都口头概述了他们的研究， 在NIDDK夏季研究研讨会上赠送科学海报，并将提供机构支持 提交摘要，供在区域和国家会议上提交。该计划结合了WFIRM 教师，近乎同行的研究生，并利用与WFSM泌尿外科系的伙伴关系，VT- WF生物医学工程与科学学院和WFIRM膀胱研究中心。实现我们的 将通过现有的多个区域和国家伙伴关系促进实现这些目标，包括科学、教育和 少数群体服务机构加强招聘和专业发展，特别是继续关注库尔德人 研究优先事项。总体而言，我们预计这些活动和方法将加强 自我认知、科学家认知、职业意向和在术语和Kud研究领域的成功 横跨学术、政府和行业部门。

PROJECT SUMMARY This 5-year Summer Undergraduate Research Institute for Meeting Challenges in Kidney and Urologic Diseases (KUD) at the Wake Forest Institute for Regenerative Medicine (WFIRM), offers diverse cohorts of 8 undergraduate students each summer (2022-2027) 10-week multidisciplinary research opportunities utilizing tissue engineering and regenerative medicine (TERM) strategies to address challenges relevant to the prevention, and treatment of kidney and urologic diseases. With interest in addressing the perseverance of the “leaky pipeline” negatively impacting the diversity of the biomedical workforce, we focus on participation of under-represented minority groups, women, and non-traditional students – including students attending 2- and 4- year universities with limited research and first-generation students. Through companion foci of disparities in KUD research and health care, coupled with research courses for skill development and novel educational/career persistence interventions to support student participants, we expect to: 1) enhance diverse students’ participation, learning and mentored research experience with faculty and near-peer graduate mentors during and beyond the 10-week on-site program; 2) enhance students’ knowledge, career intentions and persistence in TERM in KUD research, specifically, and careers in biomedical research broadly; 3) develop and implement a specialized career intentions and perceptions evaluation approach; 4) make a bigger impact on the community; and 5) increase matriculation into graduate, PhD, and MD/PhD programs and careers with focus in TERM and KUD research. These goals will be accomplished via a highly coordinated, mentored interdisciplinary summer research institute with a combination of hands-on and “virtual” research activities, instrumentation training, didactic components, specialized workshops, seminars and mini courses available across participating departments and centers and other funded NIDDK R25 programs, spanning bioethics, responsible conduct of research, health disparities, oral and written communications, and program-tailored education and career development perceptions and intentions evaluation. All students provide an oral overview of their research, present scientific posters at the NIDDK Summer Research Symposium and will be provided institutional support for submitting abstracts for presentation at regional and national conferences. The program incorporates WFIRM faculty, near-peer graduate students and leverages partnerships with the WFSM Department of Urology, the VT- WF School of Biomedical Engineering and Sciences and the WFIRM Bladder Research Center. Achieving our goals will be facilitated by multiple extant regional and national partnerships with scientific, educational and minority serving institutions to enhance recruitment, professional development and, notably, retain focus on KUD research priorities. Overall, we expect these activities and approaches will reinforce positive alignment between self-perceptions, perceptions of scientists, and career intentions and success in TERM and KUD research fields across academic, government, and industry sectors.