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Posterior Parietal Contributions to Spatial and Social Cognition

后顶叶对空间和社会认知的贡献

基本信息

批准号：
10705642
负责人：
Taylor Blaine Wise
金额：
$ 4.87万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2024-09-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10705642
关键词：
Address Advisory Committees Animal Model Animals Appointment Area Attention Behavior Behavioral Behavioral Paradigm Biological Sciences Brain Calcium Callithrix Cognition Cognitive Complex Control Animal Data Discrimination Distant Electrophysiology (science)Environment Evolution Genetic Genetic Techniques Human Image Impairment Institution Investigation Knowledge Learning Literature Mentors Methodology Modeling Neurosciences Parietal Parietal Lobe Performance Phase Postdoctoral Fellow Primates Process Rattus Research Rodent Rodent Model Role Shapes Social Distance Stimulus Technical Expertise Techniques Technology Testing Time Training Work base career cognitive function cognitive neuroscience cognitive process comparative design experience frontier in vivo information processing interest multisensory neural neuromechanism neurotoxic nonhuman primate novel optogenetics pre-doctoral pressure programs recruit skills social social cognition social relationships spatial integration statistics theories tool

项目摘要

PROJECT SUMMARY Abstract cognition is defined as the ability to process information not observed in the physical world, such as time, number, and social relationships. Evolutionary theories posit that selective pressures shaped the mammalian brain to manage increasingly abstract representations by co-opting cortical regions initially required for more concrete cognitive processes — such as spatial cognition — to also support more complex processes — such as social cognition. Research focused on similarities across spatial and social cognition is growing, yet few have investigated the neural bases of these similarities and whether they are similar mechanistically. The posterior parietal cortex (PPC) is implicated in both spatial and social cognition, but there are open questions about 1) how the PPC supports spatial and social cognition, and 2) whether and how the PPC is involved in the integration of information across domains. This proposal exploits an underutilized approach in cognitive neuroscience — the ability to study higher cognition using the powerful tools available in rodents. Indeed, as social animals and expert navigators, rats provide an ideal model to expand our knowledge of PPC function and its role in spatial and social cognition. The candidate, Taylor Wise, proposes to build on prior research in the sponsor’s lab by comparing the PPC’s role in spatial cognition with its role in social cognition. Completed dissertation work examined PPC function in spatial information processing and sociality through permanent (neurotoxic) and transient (chemogenetic) inactivation techniques. Rats with compromised PPC function showed spared performance on tasks using simple spatial environments and on tests of social exploration, but showed modest deficits in recognizing complex, context-dependent spatial configurations. This suggests the PPC is selectively recruited in tasks that require processing of information at a higher level of abstraction. Planned dissertation work will shed light on the PPC’s role in spatial and social information processing using a novel behavioral paradigm and cutting-edge technologies for manipulating PPC function. In her resubmission, Taylor provides new data demonstrating rats ability to discriminate spatial distances, a critical piece of her dissertation. Taylor will also receive training in advanced statistics and computation in the F99 phase, paving the way for further training in her K00. This proposal includes a thorough plan for finding a postdoctoral mentor that shares an interest in higher-order cognition, which will help to refine Taylor’s current graduate work. One avenue for postdoctoral research is to identify primate models, possibly marmosets, that are appropriate for neural manipulation of social cognition, and can build upon the Taylor’s rodent expertise. Under the guidance of the sponsor and scientific advisory committee, this training plan will enhance Taylor’s current skills and identify a postdoctoral appointment best prepared to propel her into an independent career in comparative behavioral neuroscience at an academic research institution.

项目总结