Posterior Parietal Contributions to Spatial and Social Cognition

后顶叶对空间和社会认知的贡献

• 批准号: 10610128
• 负责人: Taylor Blaine Wise
• 金额: $ 4.78万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10610128
• 关键词: Address; Advisory Committees; Animal Model; Animals; Appointment; Area; Attention; Behavior; Behavioral; Behavioral Paradigm; Biological Sciences; Brain; Calcium; Callithrix; Cognition; Cognitive; Complex; Control Animal; Data; Discrimination; Distant; Electrophysiology (science); Environment; Evolution; Human; Image; Impairment; Institution; Investigation; Knowledge; Learning; Light; Literature; Mentors; Methodology; Modeling; Neurosciences; Parietal; Parietal Lobe; Performance; Phase; Postdoctoral Fellow; Primates; Process; Rattus; Research; Rodent; Rodent Model; Role; Social Distance; Social support; Stimulus; Technical Expertise; Techniques; Technology; Testing; Time; Training; Work; base; career; cognitive function; cognitive neuroscience; cognitive process; comparative; design; experience; frontier; in vivo; information processing; interest; multisensory; neuromechanism; neurotoxic; nonhuman primate; novel; optogenetics; pressure; programs; recruit; relating to nervous system; skills; social; social cognition; social relationships; spatial integration; statistics; theories; tool

PROJECT SUMMARY Abstract cognition is defined as the ability to process information not observed in the physical world, such as time, number, and social relationships. Evolutionary theories posit that selective pressures shaped the mammalian brain to manage increasingly abstract representations by co-opting cortical regions initially required for more concrete cognitive processes — such as spatial cognition — to also support more complex processes — such as social cognition. Research focused on similarities across spatial and social cognition is growing, yet few have investigated the neural bases of these similarities and whether they are similar mechanistically. The posterior parietal cortex (PPC) is implicated in both spatial and social cognition, but there are open questions about 1) how the PPC supports spatial and social cognition, and 2) whether and how the PPC is involved in the integration of information across domains. This proposal exploits an underutilized approach in cognitive neuroscience — the ability to study higher cognition using the powerful tools available in rodents. Indeed, as social animals and expert navigators, rats provide an ideal model to expand our knowledge of PPC function and its role in spatial and social cognition. The candidate, Taylor Wise, proposes to build on prior research in the sponsor’s lab by comparing the PPC’s role in spatial cognition with its role in social cognition. Completed dissertation work examined PPC function in spatial information processing and sociality through permanent (neurotoxic) and transient (chemogenetic) inactivation techniques. Rats with compromised PPC function showed spared performance on tasks using simple spatial environments and on tests of social exploration, but showed modest deficits in recognizing complex, context-dependent spatial configurations. This suggests the PPC is selectively recruited in tasks that require processing of information at a higher level of abstraction. Planned dissertation work will shed light on the PPC’s role in spatial and social information processing using a novel behavioral paradigm and cutting-edge technologies for manipulating PPC function. In her resubmission, Taylor provides new data demonstrating rats ability to discriminate spatial distances, a critical piece of her dissertation. Taylor will also receive training in advanced statistics and computation in the F99 phase, paving the way for further training in her K00. This proposal includes a thorough plan for finding a postdoctoral mentor that shares an interest in higher-order cognition, which will help to refine Taylor’s current graduate work. One avenue for postdoctoral research is to identify primate models, possibly marmosets, that are appropriate for neural manipulation of social cognition, and can build upon the Taylor’s rodent expertise. Under the guidance of the sponsor and scientific advisory committee, this training plan will enhance Taylor’s current skills and identify a postdoctoral appointment best prepared to propel her into an independent career in comparative behavioral neuroscience at an academic research institution.

项目摘要 抽象认知被定义为处理未在物理世界中观察到的信息的能力，例如 时间，数字和社会关系。选择性压力塑造的进化理论海报 哺乳动物大脑通过最初需要的皮质区域来管理越来越抽象的表示 对于更具体的认知过程（例如空间认知），也支持更复杂的过程 - 例如社会认知。研究着重于空间和社会认知之间的相似性的研究正在增长，但 很少有人研究了这些相似性的神经碱，以及它们是否在机械上是相似的。这 后顶皮层（PPC）在空间和社会认知中均实施，但是有开放的问题 大约1）PPC如何支持空间和社会认知，以及2）PPC是否以及如何参与 跨域的信息集成。该建议利用了认知中未充分利用的方法 神经科学 - 使用啮齿动物中可用的强大工具研究更高认知的能力。确实，如 社会动物和专家导航员，大鼠提供了一个理想的模型，以扩大我们对PPC功能的了解和 它在空间和社会认知中的作用。候选人泰勒·怀斯（Taylor Wise）提出的提议是基于先前研究 赞助商的实验室通过将PPC在空间认知中的作用与其在社会认知中的作用进行比较。完全的 论文工作通过永久性的空间信息处理和社会性研究了PPC功能 （神经毒性）和瞬时（化学）灭活技术。显示折衷的PPC功能的大鼠 使用简单的空间环境和社交探索测试在任务上保留绩效，但显示 谦虚定义在识别复杂的，与上下文相关的空间配置时定义。这表明PPC是 选择性地招募在需要更高水平的抽象水平处理信息的任务中。计划 论文工作将阐明PPC使用小说中PPC在空间和社会信息处理中的作用 用于操纵PPC功能的行为范式和尖端技术。在她的重新提交时，泰勒 提供了新的数据，证明了大鼠歧视空间距离的能力，这是她论文的关键部分。 泰勒还将在F99阶段接受高级统计和计算的培训，为 在她的K00中进一步培训。该提案包括一个详尽的计划，以寻找分享的博士后心理 对高阶认知的兴趣，这将有助于完善泰勒目前的研究生工作。一个途径 博士后研究是为了识别适合神经元的主要模型，可能 操纵社会认知，并以泰勒的啮齿动物专业知识为基础。在 赞助商和科学咨询委员会，该培训计划将提高泰勒的当前技能，并确定 博士后预约最好准备将她推向比较行为的独立职业 学术研究机构的神经科学。