Bionformatics Resource Core

生物信息学资源核心

• 批准号: 10705728
• 负责人: Katherine Phoenix Liao
• 金额: $ 26.19万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705728
• 关键词: Adult; Area; Automobile Driving; Bioinformatics; Childhood; Clinical Data; Clinical Investigator; Clinical Research; Collaborations; Communities; Computerized Medical Record; Consultations; Data; Development; Disease Outcome; Disease model; EFRAC; Education; Faculty; Feasibility Studies; Fostering; Foundations; Grant; Institution; Learning; Machine Learning; Methodology; Methods; Mission; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Natural Language Processing; Patient Care; Patient-Focused Outcomes; Phenotype; Pilot Projects; Publishing; Research; Research Personnel; Resources; Rheumatism; Rheumatology; Services; Technology; Work; advanced analytics; bioinformatics resource; causal model; data integration; data sharing; design; disorder risk; experience; federated learning; health equity; interest; medical schools; programs; research study; social health determinants; supervised learning; tool; treatment effect; unsupervised learning

PROJECT SUMMARY In this renewal, we build on our experience serving as the VERITY Bioinformatics Core, expanding Core services to include advancements in the field since the last application. Research using electronic medical record (EMR) data continues to grow with increasing availability of EMR data. Simultaneously, methods to utilize data for research have also advanced including natural language processing (NLP) and machine learning (ML) to extract crucial clinical data embedded in narrative notes, and to include these data in models of disease risk and outcomes. However, there remains a large gap between access to raw EMR data optimized for billing and patient care, and the ability to fully and appropriately utilize these data in clinical research. Through consultations, courses offered as part of the Bioinformatics Core, and current Core projects, we have identified 4 areas of high demand and/or unmet need for clinical investigators: (1) phenotyping using EMR data; (2) extraction of clinical data from narrative notes using NLP, including early applications of this technology to study social determinants of health; (3) use of EMR for studies of treatment effects and applications of causal inference methods; and (4) approaches for multi-institutional EMR studies without requiring direct sharing of data (termed federated learning). The mission of the Bioinformatics Core remains supporting investigators from the pediatric and adult rheumatic and musculoskeletal (MSK) research community to apply and integrate bioinformatics approaches to clinical research studies using EMR data. While our target audience remains trainees and junior faculty, in this renewal, our expanded services are also designed for established investigators interested in incorporating bioinformatics to their research programs. Aim 1. To provide methods for investigators to obtain robust and accurate phenotypes using information from EMRs and integrating these data for clinical studies. This requires applying supervised and unsupervised machine learning approaches for phenotyping with EMR data. As well, we will utilize causal inference methods applied to EMR data for studies of treatment effects. Aim 2. To provide NLP support enabling clinical research studies with EMR data. We will support and develop the use of NLP to incorporate social determinants of health (SDoH) in studies of health equity using EMR data. As well, we will support and educate investigators on the use of NLP based data and tools. Aim 3. To strengthen existing ties and build new partnerships between the rheumatic and MSK clinical research and bioinformatics communities through Core platforms and consulting services. The Bioinformatics Core team and a network of expert advisors will perform consultations, provide educational services, and deliver bioinformatics research services to the Research Community. Additionally, we will build on our foundation to enable cross-institutional studies with federated learning approaches for clinical studies on rheumatic and musculoskeletal conditions.

项目摘要 在这种续约中，我们以作为Verity BioInformitics核心的经验为基础，扩大了核心 自上次应用程序以来，要包括该领域的进步的服务。使用电子医疗的研究 记录（EMR）数据随着EMR数据的可用性的增加而继续增长。同时，方法 利用数据进行了进步，包括自然语言处理（NLP）和机器 学习（ML）提取叙事说明中嵌入的关键临床数据，并将这些数据包括在模型中 疾病风险和结果。但是，访问RAW EMR数据之间仍然存在很大的差距 针对计费和患者护理进行了优化，以及在临床上充分利用这些数据的能力 研究。通过咨询，作为生物信息学核心的一部分提供的课程以及当前的核心项目， 我们已经确定了4个需求量高和/或对临床研究人员的需求未满足的领域：（1）使用表型 EMR数据； （2）使用NLP从叙述说明中提取临床数据，包括早期应用 研究健康的社会决定因素的技术； （3）使用EMR进行治疗效应和 因果推理方法的应用； （4）无需进行多机构EMR研究的方法 需要直接共享数据（称为联合学习）。 生物信息学核心的使命仍然支持小儿的调查人员 成人风湿和肌肉骨骼（MSK）研究社区应用和整合生物信息学 使用EMR数据进行临床研究的方法。虽然我们的目标受众仍然是受训者和 初级教师，在这种续签中，我们的扩展服务也是为有兴趣的既定调查员设计的 将生物信息学纳入其研究计划。目的1。为调查人员提供方法 使用来自EMR的信息获得可靠，准确的表型，并将这些数据整合为临床 研究。这需要应用监督和无监督的机器学习方法进行表型 使用EMR数据。同样，我们将利用用于EMR数据的因果推理方法进行治疗 效果。目的2。提供NLP支持，以实现EMR数据的临床研究。我们将支持并 开发使用NLP将健康的社会决定因素（SDOH）纳入健康公平研究 EMR数据。同样，我们将支持和教育研究人员有关使用基于NLP的数据和工具的使用。目标3。 加强风湿和MSK临床研究之间的现有联系并建立新的伙伴关系 通过核心平台和咨询服务的生物信息学社区。 生物信息学核心团队和专家顾问网络将进行咨询，提供 教育服务，并向研究界提供生物信息学研究服务。此外， 我们将以我们的基础为基础，以联合学习方法的跨机构研究 关于风湿和肌肉骨骼条件的临床研究。