ASSESSMENT OF POTENTIAL TREATMENTS FOR DRUG-INDUCED RESPIRATORY DEPRESSION AND OVERDOSE TOXICITY. POP: SEPTEMBER 26, 2022 - SEPTEMBER 25, 2023. TASK O

评估药物引起的呼吸抑制和药物过量毒性的潜在治疗方法。

• 批准号: 10713095
• 负责人: FADI XU
• 金额: $ 10.27万
• 依托单位: LOVELACE BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-26 至 2023-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10713095
• 关键词: Mental Depression; Modeling; Opioid; Overdose; Pharmaceutical Preparations; Respiration; Rodent; Testing; Toxic effect; Ventilatory Depression; drug of abuse; opioid overdose; respiratory

The objectives of this project are to determine the effects of experimental compounds on respiratory parameters in rodents or other species in models relevant to the opioid overdose crisis. Compounds may be tested alone for effects on respiration (stimulation or depression), or for their ability to modulate respiratory depressant effects of opioids and possibly other drugs of abuse.

本项目的目的是确定实验化合物对与阿片类药物过量危机相关的模型中啮齿动物或其他物种呼吸参数的影响。可单独测试化合物对呼吸的影响（刺激或抑制），或其调节阿片类药物和可能的其他滥用药物的呼吸抑制作用的能力。