fMRI study of cognition, motivation, decision-making, reward, risk, aversion, negative emotion, arousal, craving, impulsivity, and stress in alcohol use disorder

功能磁共振成像研究酒精使用障碍中的认知、动机、决策、奖励、风险、厌恶、负面情绪、唤醒、渴望、冲动和压力

• 批准号: 10710498
• 负责人: Reza Momenan
• 金额: $ 23.74万
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10710498
• 关键词: Alcoholic Beverages; Arousal; Atlases; Brain; Charge; Cognition; Collaborations; Data; Decision Making; Emotional; Emotions; Failure; Functional Magnetic Resonance Imaging; Future; Image; Impulsivity; Learning; Modeling; Motivation; Participant; Patients; Reversal Learning; Rewards; Risk; Stress; alcohol abuse therapy; alcohol use disorder; craving; design; discounting; efficacy evaluation; functional near infrared spectroscopy; neural correlate; recruit; response; reward anticipation

a. Prediction Error Task. This task provides a wide variety of information regarding functions such as decision making, reward anticipation, learning and response to the failure of receiving an expected reward, all of which are implicated in AUD. In a collaboration with Dr. Lauren Atlas we are trying to model previously collected data on the Prediction Error Task to determine differences in reversal learning of patients with AUD in contrast to healthy controls. b. Negative Urgency Task. We have designed and developed a task in which we can study how stress and emotionally charged images can effect negative urgency utilizing a modified version of the delay discounting task. In this task the participants would be asked to select between an immediate reward (alcoholic beverages of choice and monetary equivalent cash) or double the amount in the future under negative conditions mentioned above. In this study we will also utilize functional near infrared spectroscopy to inspect the functional activities of the brain during this condition. Subject recruitment for this study is on the way.

a. 预测错误任务。该任务提供了有关决策、奖励预期、学习和对未能收到预期奖励的反应等功能的各种信息，所有这些都与AUD有关。在与Lauren Atlas博士的合作中，我们试图对先前收集的预测错误任务数据进行建模，以确定AUD患者与健康对照组相比逆转学习的差异。 B. 负紧急任务。我们设计并开发了一个任务，在这个任务中，我们可以利用延迟折扣任务的修改版本来研究压力和充满情感的图像如何影响消极紧迫感。在这项任务中，参与者将被要求在立即奖励（选择酒精饮料和货币等值现金）或在上述负面条件下未来加倍金额之间做出选择。在这项研究中，我们还将利用功能近红外光谱检查在这种情况下的大脑功能活动。本研究的受试者招募正在进行中。