Neuromodulation Applications in Alcohol Use Disorder

神经调节在酒精使用障碍中的应用

• 批准号: 10710500
• 负责人: Reza Momenan
• 金额: $ 31.66万
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10710500
• 关键词: Affect; Anterior; Area; Atlases; Behavioral; Brain region; COVID-19; Data; Decision Making; Development; Down-Regulation; Functional Magnetic Resonance Imaging; Impulsivity; Individual; Inpatients; Insula of Reil; Laboratories; Manuscripts; National Institute of Mental Health; Participant; Pilot Projects; Prefrontal Cortex; Preparation; Running; Techniques; Testing; Work; alcohol use disorder; comorbidity; craving; emotion regulation; functional near infrared spectroscopy; hemodynamics; improved; neural; neurofeedback; neuroregulation; prisma; prototype; recruit; repetitive transcranial magnetic stimulation; response; spectroscopic imaging

1. Development of fMRI Neurofeedback During the past three years we have worked with collaborators in NIMH and developed and implemented several neurofeedback prototypes for the Siemens 3T Prisma scanner. We have completed stage 1 of this study and continuing our recruitment for stage 2 of the study from the AUD inpatient behavioral unit. According to our results participants had more successful trials after 3 runs of practice, as well as improved downregulation of the insula, anterior cingulate, and dorsolateral prefrontal cortex (dlPFC). Greater downregulation of the latter two regions predicted greater reduction in craving. The manuscript detailing the analysis of stage 1 data is completed. 2. TMS Neuromodulation of Negative Urgency We had planned to initiate another collaborative (Dr. Atlas) study in order to assess how negative urgency relates to impulsive decision-making in individuals with alcohol use disorder (AUD); and to characterize the associated hemodynamic response in prefrontal areas using functional near infrared spectroscopy (fNIRS) imaging. Due to COVID-19 restrictions the preparation of laboratory space for this project has been delayed. Upon completion of the pilot study, we will test whether negative urgency can be modulated via prefrontal stimulation using repetitive transcranial magnetic stimulation (rTMS), as this technique has been shown to affect top-down regulatory circuits (prefrontal-limbic) during emotion regulation and impulsive decision-making, which are the two key components of negative urgency.

1. 功能磁共振神经反馈研究进展 在过去的三年里，我们与NIMH的合作者合作，为Siemens 3 T Prisma扫描仪开发并实施了几个神经反馈原型。我们已经完成了本研究的第1阶段，并继续从AUD住院行为科招募研究第2阶段的患者。 根据我们的研究结果，参与者在3次练习后有更多的成功尝试，以及改善了前扣带回，前扣带回和背外侧前额叶皮层（dlPFC）的下调。后两个区域的更大下调预测更大的渴望减少。详细说明第1阶段数据分析的手稿已完成。 2. 负紧迫感的TMS神经调节 我们计划启动另一项合作（Atlas博士）研究，以评估负紧迫感如何与酒精使用障碍（AUD）患者的冲动决策相关;并使用功能性近红外光谱（fNIRS）成像表征前额区的相关血流动力学反应。由于COVID-19的限制，该项目的实验室空间准备工作已被推迟。在初步研究完成后，我们将测试是否可以通过使用重复经颅磁刺激（rTMS）的前额叶刺激来调制负紧迫感，因为这种技术已被证明会影响情绪调节和冲动决策过程中的自上而下的调节回路（前额叶边缘），这是负紧迫感的两个关键组成部分。