Neuromodulation Applications in Alcohol Use Disorder

神经调节在酒精使用障碍中的应用

• 批准号: 10928524
• 负责人: Reza Momenan
• 金额: $ 35.81万
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10928524
• 关键词: Affect; Algorithms; Anterior; Area; Atlases; Behavioral; Brain region; COVID-19; Corpus striatum structure; Decision Making; Down-Regulation; Evaluation; Feedback; Functional Magnetic Resonance Imaging; Goals; Impulsivity; Individual; Inpatients; Insula of Reil; Journals; Laboratories; Manuscripts; Mental Health; Methods; Participant; Patient Self-Report; Performance; Pilot Projects; Prefrontal Cortex; Preparation; Psychophysiology; Publishing; Running; Techniques; Testing; Time; Work; alcohol craving; alcohol use disorder; comorbidity; craving; emotion regulation; functional near infrared spectroscopy; hemodynamics; improved; interest; neural; neurofeedback; neuroregulation; prisma; prototype; recruit; repetitive transcranial magnetic stimulation; response; spectroscopic imaging; success; support vector machine

Evaluating Real Time fMRI Neurofeedback - During the past four years we have worked with collaborators in the National Institute on Mental Health (NIMH) and developed and implemented several neurofeedback prototypes for the Siemens 3T Prisma scanner. We have completed stage 1 of this study and continue our recruitment for stage 2 of the study from the Alcohol Use Disorder (AUD) inpatient behavioral unit. A manuscript was published in the journal of Psychophysiology (Fede et al., 2023) detailing the evaluation of three real time neurofeedback algorithms with the goal of downregulating craving. In this study participants received one of three types of neurofeedback: multi-region of interest (ROI), support vector machine with continuous feedback (cSVM) and support vector machine with intermittent feedback (iSVM). Performance was assessed on the success rate, change in neural downregulation and change in self-reported craving for alcohol. According to our results, participants had more successful trials in run 4 versus 1, as well as improved downregulation of the insula, anterior cingulate, and dorsolateral prefrontal cortex (dlPFC). Greater downregulation of the latter two regions predicted greater reduction in craving. iSVM performed significantly worse than the other two methods. Downregulation of the striatum and dlPFC, enabled by ROI but not cSVM neurofeedback, was correlated with a greater reduction in craving. Our results suggested an advantage of multi-ROI over SVM and intermittent feedback approaches. TMS Neuromodulation of Negative Urgency We had planned to initiate another collaborative study with Dr. Lauren Atlas in order to assess how negative urgency relates to impulsive decision-making in individuals with alcohol use disorder (AUD); and to characterize the associated hemodynamic response in prefrontal areas using functional near infrared spectroscopy (fNIRS) imaging. Due to COVID-19 restrictions the preparation of laboratory space for this project has been delayed. Upon completion of the pilot study, we will test whether negative urgency can be modulated via prefrontal stimulation using repetitive transcranial magnetic stimulation (rTMS), as this technique has been shown to affect top-down regulatory circuits (prefrontal-limbic) during emotion regulation and impulsive decision-making, which are the two key components of negative urgency.

评估真实的时间功能磁共振成像神经反馈-在过去的四年中，我们一直与合作者在国家精神卫生研究所（NIMH）和开发和实施了几个神经反馈原型的西门子3 T棱镜扫描仪。我们已经完成了本研究的第一阶段，并继续从酒精使用障碍（AUD）住院行为科招募研究第二阶段的人员。一篇手稿发表在《心理生理学杂志》（Fede et al.，2023）详细描述了以下调渴望为目标的三种真实的时间神经反馈算法的评估。在这项研究中，参与者接受了三种类型的神经反馈之一：多感兴趣区域（ROI），连续反馈支持向量机（cSVM）和间歇反馈支持向量机（iSVM）。根据成功率、神经下调的变化和自我报告的酒精渴望的变化来评估表现。根据我们的研究结果，参与者在第4轮与第1轮的试验中获得了更多的成功，并且改善了前扣带回，前扣带回和背外侧前额叶皮层（dlPFC）的下调。后两个区域的更大下调预测更大的渴望减少。iSVM的表现明显差于其他两种方法。纹状体和dlPFC的下调，由ROI而不是cSVM神经反馈实现，与渴望的更大减少相关。我们的研究结果表明，多ROI的优势SVM和间歇反馈的方法。 负紧迫感的TMS神经调节 我们计划与Lauren Atlas博士开展另一项合作研究，以评估负紧迫感与酒精使用障碍（AUD）患者冲动决策的关系;并使用功能性近红外光谱（fNIRS）成像来表征前额区的相关血流动力学反应。由于COVID-19的限制，该项目的实验室空间准备工作已被推迟。在初步研究完成后，我们将测试是否可以通过使用重复经颅磁刺激（rTMS）的前额叶刺激来调制负紧迫感，因为这种技术已被证明会影响情绪调节和冲动决策过程中的自上而下的调节回路（前额叶边缘），这是负紧迫感的两个关键组成部分。