fMRI study of cognition, motivation, decision-making, reward, risk, aversion, negative emotion, arousal, craving, impulsivity, and stress in alcohol use disorder

功能磁共振成像研究酒精使用障碍中的认知、动机、决策、奖励、风险、厌恶、负面情绪、唤醒、渴望、冲动和压力

• 批准号: 10927713
• 负责人: Reza Momenan
• 金额: $ 35.81万
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10927713
• 关键词: Affect; Alcoholic Beverages; Alcohols; Amygdaloid structure; Arousal; Atlases; Behavior; Beverages; Brain; COVID-19; Charge; Clinical; Cognition; Cognitive; Collaborations; Cues; Data; Decision Making; Development; Disease; Emotional; Emotions; Failure; Functional Magnetic Resonance Imaging; Functional disorder; Future; Image; Impulsivity; Learning; Maintenance; Manuscripts; Memory; Modeling; Morals; Motivation; Outpatients; Participant; Patient Recruitments; Patients; Perception; Play; Reversal Learning; Rewards; Risk; Role; Stimulus; Stress; Structure of middle temporal gyrus; Structure of supramarginal gyrus; alcohol abuse therapy; alcohol use disorder; antisocial behavior; attentional modulation; combat; craving; design; discounting; efficacy evaluation; emotion dysregulation; executive function; functional MRI scan; functional near infrared spectroscopy; negative affect; neural; neural correlate; novel; recruit; response; reward anticipation; social stigma; substance use

Emotional Dysregulation - Emotional affects are known to play critical role in development and maintenance of alcohol use disorder. However, the difference in neural substrates of socio-emotional perceptions and decision making in the presence of disorder distractors such as images of alcohol-containing beverages are understudied. Disruption in the interaction of frontal, limbic and temporoparietal networks might be in part the reason for dysregulated processing of emotionally unpleasant stimuli. We recruited patients with AUD and healthy controls for this study. While undergoing an fMRI scan, participants viewed pairs of images consisting of a moral (i.e. emotionally valanced) or neutral cue and an alcohol or neutral distractor. When viewing valanced cues paired with alcohol distractors (compared to neutral distractors), participants had lower neural engagement in the middle temporal gyrus, amygdala, and supramarginal gyrus. Although extension to other disorders with attention modulation dysfunction is needed, these results carry potential societal and clinical benefits by suggesting a novel, leverageable mechanism to reduce antisocial behavior and in providing a cognitive explanation for certain behaviors in substance use that may help combat persistent stigma. The manuscript for this study is under review. Task Development and Response Modeling 1. Prediction Error Task. This task provides a wide variety of information regarding functions such as decision making, reward anticipation, learning and response to the failure of receiving an expected reward, all of which are implicated in AUD. In a collaboration with Dr. Lauren Atlas we are trying to model previously collected data on the Prediction Error Task to determine differences in reversal learning of patients with AUD in contrast to healthy controls. This project has been on hold due to staff transitions in Dr. Atlas's lab. 2. Negative Urgency Task. We have designed and developed a task in which we can study how stress and emotionally charged images can effect negative urgency utilizing a modified version of the delay discounting task. In this task the participants would be asked to select between an immediate reward (alcoholic beverages of choice and monetary equivalent cash) or double the amount in the future under negative conditions mentioned above. In this study we will also utilize functional near infrared spectroscopy to inspect the functional activities of the brain during this condition. Due to staff transitions and COVID-19 healthy outpatient recruitment has not yet started.

情绪失调-已知情绪影响在酒精使用障碍的发展和维持中起关键作用。然而，在存在诸如含酒精饮料的图像之类的干扰物的情况下，社会情绪感知和决策的神经基质的差异未得到充分研究。额叶、边缘系统和颞顶网络的相互作用中断可能是情绪不愉快刺激处理失调的部分原因。本研究招募了AUD患者和健康对照。在接受功能磁共振成像扫描时，参与者观看由道德（即情感上的价值）或中性线索和酒精或中性干扰物组成的图像对。当观察与酒精干扰配对的valanced线索（与中性干扰相比），参与者在颞中回，杏仁核和缘上回的神经参与较低。虽然扩展到其他疾病的注意力调节功能障碍是必要的，这些结果具有潜在的社会和临床效益，提出了一种新的，可替代的机制，以减少反社会行为，并在某些行为提供认知解释，在物质使用，可能有助于打击持久的耻辱。这项研究的手稿正在审查中。 任务开发和响应建模 1. 预测错误任务。该任务提供了关于诸如决策、奖励预期、学习和对接收预期奖励失败的响应等功能的各种信息，所有这些都与AUD有关。在与Lauren Atlas博士的合作中，我们试图对先前收集的预测错误任务数据进行建模，以确定AUD患者与健康对照组相比逆转学习的差异。由于阿特拉斯博士实验室的人员调动，该项目一直处于搁置状态。 2. 负紧急任务。我们设计并开发了一个任务，在这个任务中，我们可以利用延迟折扣任务的修改版本来研究压力和充满情感的图像如何影响消极紧迫感。在这项任务中，参与者将被要求在立即奖励（选择酒精饮料和货币等值现金）或在上述负面条件下未来加倍金额之间做出选择。在这项研究中，我们还将利用功能近红外光谱检查在这种情况下的大脑功能活动。由于员工过渡及COVID-19健康门诊招募尚未开始。