Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks

驯服氟:用于氟化构件异质输送的金属有机框架

基本信息

  • 批准号:
    10798398
  • 负责人:
  • 金额:
    $ 24.37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Project Summary Despite decades of reaction development, medicinal chemists still frequently face synthetic barriers when preparing molecules with potential therapeutic value. For example, the substitution of C–H bonds for C–F bonds in a target molecule can improve its metabolic stability, membrane permeability, and biological activity, but this substitution is often impossible to realize in the laboratory. This obstacle arises because the fluorination of otherwise simple building blocks or reagents generally renders them gaseous, toxic, corrosive, or unstable. While this “reagent problem” is not limited to organofluorine chemistry, it has prevented significant advances in this area. Therefore, the overall objective of the proposed research is to “tame” the reactivity of fluorinated building blocks and enable their use for the construction of complex fluorinated molecules. Specifically, the proposed multidisciplinary program aims to employ insoluble porous materials, which commonly serve as “hosts” for “guest” molecules in materials science, to control the reactivity of fluorinating agents. The resulting heterogeneous species will function as “nanovessels” capable of controllably releasing the stored reagents or as “nanoreactors” that facilitate new transformations within their pores. The central hypothesis of this proposal is that metal–organic frameworks, a relatively new class of porous, crystalline materials constructed from organic “linkers” and inorganic “secondary building units,” are the ideal platform to achieve this objective due to their unparalleled structural tunability. This research aim is part of the PI’s broader research program to unlock the potential of metal–organic frameworks for applications in organic synthesis, medicine, and structural biology. The PI is also exploring the use of electricity as a low-cost tool to enable the synthesis of complex molecules This administrative supplement will support the purchase of a powder X-ray diffractometer (PXRD) to facilitate the characterization of MOFs prepared as part of the parent proposal. PXRD is the most important method for determining the atomic-scale structures of nano-crystalline materials but remains challenging to carry out at Cornell University. Typically, synchrotron X-ray sources must be used to collect data, which results in significant delays (>6 weeks) between sample preparation and data acquisition. This purchase would allow for the acquisition of PXRD data in minutes instead of weeks at Cornell University.
项目总结

项目成果

期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Unexpected Direct Synthesis of Tunable Redox-Active Benzil-Linked Polymers via the Benzoin Reaction.
  • DOI:
    10.1021/acsapm.2c02047
  • 发表时间:
    2022-12
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Christina Cong;Jaehwan Kim;Cara N. Gannett;H. Abruña;P. Milner
  • 通讯作者:
    Christina Cong;Jaehwan Kim;Cara N. Gannett;H. Abruña;P. Milner
Electroreductive Radical Borylation of Unactivated (Hetero)Aryl Chlorides Without Light by Using Cumulene-Based Redox Mediators.
使用基于积烯的氧化还原介体,在无光的情况下对未活化的(杂)芳基氯进行电还原自由基硼化。
Flexible Backbone Effects on the Redox Properties of Perylenediimide-Based Polymers.
  • DOI:
    10.1021/acsami.3c06065
  • 发表时间:
    2023-08
  • 期刊:
  • 影响因子:
    9.5
  • 作者:
    Jaehwan Kim;Yogita Shirke;P. Milner
  • 通讯作者:
    Jaehwan Kim;Yogita Shirke;P. Milner
High-Concentration Self-Assembly of Zirconium- and Hafnium-Based Metal-Organic Materials.
  • DOI:
    10.1021/jacs.3c02787
  • 发表时间:
    2023-06
  • 期刊:
  • 影响因子:
    15
  • 作者:
    Ronald T. Jerozal;Tristan A. Pitt;S. MacMillan;P. Milner
  • 通讯作者:
    Ronald T. Jerozal;Tristan A. Pitt;S. MacMillan;P. Milner
Investigation of ion-electrode interactions of linear polyimides and alkali metal ions for next generation alternative-ion batteries.
  • DOI:
    10.1039/d2sc02939a
  • 发表时间:
    2022-08-17
  • 期刊:
  • 影响因子:
    8.4
  • 作者:
  • 通讯作者:
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Phillip John Milner其他文献

Phillip John Milner的其他文献

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{{ truncateString('Phillip John Milner', 18)}}的其他基金

Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks
驯服氟:用于氟化构件异质输送的金属有机框架
  • 批准号:
    10225599
  • 财政年份:
    2020
  • 资助金额:
    $ 24.37万
  • 项目类别:
Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks
驯服氟:用于氟化构件异质输送的金属有机框架
  • 批准号:
    10671605
  • 财政年份:
    2020
  • 资助金额:
    $ 24.37万
  • 项目类别:
Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks
驯服氟:用于氟化构件异质输送的金属有机框架
  • 批准号:
    10451724
  • 财政年份:
    2020
  • 资助金额:
    $ 24.37万
  • 项目类别:
Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks
驯服氟:用于氟化构件异质输送的金属有机框架
  • 批准号:
    10029224
  • 财政年份:
    2020
  • 资助金额:
    $ 24.37万
  • 项目类别:

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