Preventing Alcohol Use Disorders and Alcohol-Related Harms in Pacific Islander Young Adults

摘要 美国的夏威夷原住民/太平洋岛民（NPI）是一个迅速增长的种族群体， 与酒精有关的差异在NPI社区，年轻人（18-30岁）承受的酒精负担最大 我们早期的NIAAA R21研究显示，近50%的使用障碍（AUD）和酒精相关的危害， 居住在社区的NPI年轻人有严重的风险，或者有40%的人经历过酒精相关的AUDs 伤害（例如，健康、社会、工作）。尽管如此，NPI的年轻人接受了最低限度的酒精研究 这导致缺乏有效的干预措施来预防或降低他们的极端澳元风险。 在我们的NIAAA R21研究结果的指导下，这项重新提交的R 01研究将对这一公共卫生差距做出回应。 通过提炼和功效测试SPARY（太平洋赋权和减少酒精战略）：一部小说， 基于文化的AUD预防干预NPI年轻人。基于我们的R21开发模型， 针对NPI年轻人的SPECIFICATION干预组件（以前由来自以下国家的NPI在我们的R21中选择和塑造） 现有的AUD预防干预措施），在目标1中，我们将从我们的NPI形 R21 AUD预防组件。为了组装手册，我们将使用我们的文化一致的干预 涉及社区专家和公民小组的咨询理事会的非营利机构的设计方法， 创新的研究方法，反映新产品导入集体决策的做法-以获得关键的反馈 用于从具有高AUD风险的NPI年轻人和非正式NPI提供者中提炼SPRINT内容/组件。 在目标2中，我们将通过3个领先的专家评审，审查和完善我们的治疗成分和手册。 酒精研究专家和可行性试点测试手册与36个NPI年轻人高风险澳元， 可行性，可接受性和影响，使用我们的研究结果来完成我们的随机对照试验的SPECTRA。在 目的3：通过对240例NPI患者进行全面随机对照试验， 洛杉矶县和阿肯色州西北部两个大型NPI社区中具有高AUD风险的年轻成年人 为了普遍性。为配合社区研究的原则，我们会与NPI分享研究结果 通过公开报告和演讲向社会提供信息，并通过学术报告向科学界提供信息。 介绍和手稿。

Abstract Native Hawaiians/Pacific Islanders (NPI) in the U.S. are a rapidly growing racial group that suffers severe alcohol-related disparities. In NPI communities, young adults (18-30 years) endure the greatest burden of alcohol use disorders (AUD) and alcohol-related harms with our earlier NIAAA R21 study revealing that almost 50% of community-dwelling NPI young adults are at heavy risk for, or have, AUDs with 40% experiencing alcohol-related harms (e.g., health, social, work). Despite this, NPI young adults have received minimal alcohol research attention, leading to a lack of effective interventions to prevent or reduce their extreme AUD risk. Guided by the findings of our NIAAA R21, this resubmitted R01 study will respond to this public health gap by refining and efficacy testing SPEAR (Strategies for Pacific Empowerment and Alcohol Reduction): a novel culturally grounded AUD prevention intervention for NPI young adults. Building on our R21-developed Model of SPEAR intervention components for NPI young adults (previously chosen and shaped in our R21 by NPIs from existing AUD prevention interventions), in Aim 1, we will assemble our treatment manual from our NPI-shaped R21 AUD prevention components. To assemble the manual, we will use our culturally congruent intervention design methodology for NPIs involving an Advisory Council of community experts and citizens’ panels—an innovative research approach that mirrors NPI collective decision-making practices—to obtain critical feedback for refining SPEAR content/components from NPI young adults with high AUD risk and informal NPI providers. In Aim 2, we will review and refine our treatment components and manual through expert review by 3 leading alcohol research experts and feasibility pilot test the manual with 36 NPI young adults with high AUD risk for feasibility, acceptability, and impact, using our findings to finalize SPEAR for our randomized controlled trial. In Aim 3, we will test the efficacy of SPEAR by conducting a full-scale randomized controlled trial with 240 NPI young adults with high AUD risk in two large NPI communities in Los Angeles County and Northwest Arkansas for generalizability. Aligning with community research principles, we will share study findings with the NPI community through public reports and presentations, and to the scientific community through academic presentations and manuscripts.