1/2 Discovery and validation of neuronal enhancers associated with the development of psychiatric disorders

项目总结/摘要 该建议旨在扩展PsychENCODE数据分析核心（DAC）的工作 资助实施一项长期的数据和资源管理计划， 家长赠款和更广泛的PsychENCODE财团，并继续支持数据 为PsychENCODE联盟再协调一年。Sage Bionetwork作为 在过去的7年里，PsychENCODE项目的DCC一直负责跟踪， 管理、分发数据、方法和分析结果，并通过以下方式支持DAC 获取原始数据和重新分发统一数据集。在这个角色中，我们已经建立了 收集和整理数据的过程，分析方法，并为以下方面提供空间： 协同分析这一努力最终在第一阶段的分析协调散装组织 来自>2000个供体大脑的基因组、转录组和表观基因组数据集， 在《科学》特刊上发表的手稿。在第二阶段也在进行类似的努力， 单细胞数据。PsychENCODE数据集的总数据量接近500 TB 存储在Synapse中，一个NIH数据存储库，并在自定义知识门户中提供， PsychEncode门户。在这里，我们建议如何将这些数据的长期管理过渡到 NIMH数据档案（NDA），以及来自14项第二阶段赠款的数据支持，结束日期超过 2023年3月31日，项目结束。

Project Summary/Abstract This proposal is designed to extend the work of the PsychENCODE Data Analysis Core (DAC) grant to implement a long term stewardship plan for the data and resources generated both by the parent grant and the broader PsychENCODE consortium, and continue to support data coordinating for the PsychENCODE consortium for an additional year. Sage Bionetwork, as the DCC of the PsychENCODE program over the last 7 years has been responsible for tracking, curating, distributing of data, methods, and analysis results as well as supporting the DAC through access to raw data and re-distribution of harmonized datasets. In this role we have built out processes for collecting and curating data, analytical methods and provided spaces for collaborative analysis. This effort culminated in the phase I analysis of a harmonized bulk tissue dataset of genomic, transcriptomic, and epigenomic data from >2000 donor brains resulting in manuscripts published in a special issue of Science. A similar effort is ongoing in phase II focusing on single cell data. Combined, the PsychENCODE data corpus is close to 500 terabytes of data stored in Synapse, an NIH data repository and made available in a custom knowledge portal, the PsychEncode portal. Here we propose how to transition long term stewardship of this data to the NIMH data archive (NDA), and support of data from 14 phase II grants with an end date beyond the March-31 2023 project end of the parent grant.