1/2 Discovery and validation of neuronal enhancers associated with the development of psychiatric disorders

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Project Summary/Abstract This proposal is designed to extend the work of the PsychENCODE Data Analysis Core (DAC) grant to implement a long term stewardship plan for the data and resources generated both by the parent grant and the broader PsychENCODE consortium, and continue to support data coordinating for the PsychENCODE consortium for an additional year. Sage Bionetwork, as the DCC of the PsychENCODE program over the last 7 years has been responsible for tracking, curating, distributing of data, methods, and analysis results as well as supporting the DAC through access to raw data and re-distribution of harmonized datasets. In this role we have built out processes for collecting and curating data, analytical methods and provided spaces for collaborative analysis. This effort culminated in the phase I analysis of a harmonized bulk tissue dataset of genomic, transcriptomic, and epigenomic data from >2000 donor brains resulting in manuscripts published in a special issue of Science. A similar effort is ongoing in phase II focusing on single cell data. Combined, the PsychENCODE data corpus is close to 500 terabytes of data stored in Synapse, an NIH data repository and made available in a custom knowledge portal, the PsychEncode portal. Here we propose how to transition long term stewardship of this data to the NIMH data archive (NDA), and support of data from 14 phase II grants with an end date beyond the March-31 2023 project end of the parent grant.