Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Human Genotype-Tissue Expression Project
人类发育基因型组织表达项目实验室、数据分析和协调中心 (LDACC)
基本信息
- 批准号:10709553
- 负责人:
- 金额:$ 171.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-22 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescenceAdultAffectAgeAllelesAnimalsAreaAtlasesBRAIN initiativeBiologic CharacteristicBiologicalBirthBrainBrain regionCell NucleusCellsCensusesChildhoodChromatinCollaborationsCollecting CellCommunitiesComplementConsent FormsDNADataData AnalysesDatabasesDevelopmentDimensionsDiseaseEpigenetic ProcessFundingGene ExpressionGene Expression ProfilingGene Expression RegulationGenerationsGenesGenotypeGenotype-Tissue Expression ProjectHumanHuman DevelopmentKnowledgeLaboratoriesLifeLinkMammalsMeasuresModificationMonitorNeocortexOrganPatternPopulationProductionProtocols documentationQuality ControlQuantitative Trait LociRNA SplicingRecommendationRegulationReportingResearchResolutionResourcesReview CommitteeRiskSamplingSpecimenSpliced GenesStandardizationSystemTestingTissue ProcurementsTissuesUntranslated RNAVariantWhole Bloodage groupbiobankcell typecritical perioddata disseminationdata integrationdata portalearly childhoodfetalfunctional genomicsgenetic variantgenome sequencinggenome wide association studygenomic datagenomic locushistopathological examinationhuman diseaseinfancyinsightmultimodal datamultimodalitymultiple omicsneocorticalperinatal periodpostnatalpostnatal developmentpostnatal humanpostnatal periodprenatalsingle nucleus RNA-sequencingtranscriptometranscriptome sequencing
项目摘要
PROJECT ABSTRACT
We propose to establish the Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental
Genotype-Tissue Expression (dGTEx) Project to generate, analyze, and integrate multimodal genomic data from
various tissues, with emphasis on multiple brain regions, across 4 age groups: infancy, early childhood, late
childhood and adolescence. We will develop an atlas that integrates genotyping data and functional genomic
data to help predict functional impact of noncoding genomic variants, both common and rare on gene expression.
Our project will address two key knowledge gaps. First, large-scale efforts by GTEx and other consortia have
focused on adult or prenatal ages and only to a limited extent, on the postnatal developmental ages from birth
to adolescence, critical periods because humans have prolonged postnatal development, particularly prominent
in the brain. Second, resolution at the level of specific cell types in lacking in many studies. Studying postnatal
development at the level of specific cell types is critical because the effects of genetic variants on gene regulation
are often cell-type specific. To address these critical knowledge gaps, we propose to 1) create an atlas of
pediatric tissue gene expression in bulk tissues and single cell populations, 2) analyze differences in gene
expression, regulation, and known expression QTLs and splicing QTLs across postnatal human development,
and 3) create and make available a biobank of as many tissues as possible (up to 50 tissues per donor), and
associated data for further characterization. 4) develop a data portal for data dissemination as well as integration
of our data with Genotype Tissue Expression (GTEx), Brain Initiative Cell Census Network (BICCN) and other
consortia. By so doing, we will radically expand upon earlier efforts by GTEx and create a comprehensive and
broadly available community resource on human developmental tissues, to help drive research forward in
multiple research fields, and generally any disease.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mark Bender Gerstein其他文献
Mark Bender Gerstein的其他文献
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{{ truncateString('Mark Bender Gerstein', 18)}}的其他基金
1/2 Discovery and validation of neuronal enhancers associated with the development of psychiatric disorders
1/2 与精神疾病发展相关的神经元增强剂的发现和验证
- 批准号:
10801125 - 财政年份:2023
- 资助金额:
$ 171.18万 - 项目类别:
Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sources
对来自 BRAIN Initiative 和其他公共数据源的基因组学和成像数据进行综合分析
- 批准号:
10190025 - 财政年份:2021
- 资助金额:
$ 171.18万 - 项目类别:
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Human Genotype-Tissue Expression Project
人类发育基因型组织表达项目实验室、数据分析和协调中心 (LDACC)
- 批准号:
10306961 - 财政年份:2021
- 资助金额:
$ 171.18万 - 项目类别:
A Big Data Approach to Identify Epigenetic, Transcriptomic, and Network Dynamics as Immune Dysfunction Drivers Associated with HIV Infection and Substance Use Disorder
利用大数据方法识别表观遗传、转录组和网络动态作为与 HIV 感染和药物滥用障碍相关的免疫功能障碍驱动因素
- 批准号:
10408130 - 财政年份:2020
- 资助金额:
$ 171.18万 - 项目类别:
The Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIV
耶鲁大学 Y-SCORCH 数据生成中心用于艾滋病毒背景下的单细胞阿片类药物反应
- 批准号:
10685384 - 财政年份:2020
- 资助金额:
$ 171.18万 - 项目类别:
The Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIV
耶鲁大学 Y-SCORCH 数据生成中心用于艾滋病毒背景下的单细胞阿片类药物反应
- 批准号:
10461029 - 财政年份:2020
- 资助金额:
$ 171.18万 - 项目类别:
Supplement: Human Brain Collection for Study of the Neuropathogenesis of SARS-CoV-2, HIV-1, and Opioid Use Disorder
补充:用于研究 SARS-CoV-2、HIV-1 和阿片类药物使用障碍神经发病机制的人脑采集
- 批准号:
10468477 - 财政年份:2020
- 资助金额:
$ 171.18万 - 项目类别:
The Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIV
耶鲁大学 Y-SCORCH 数据生成中心用于艾滋病毒背景下的单细胞阿片类药物反应
- 批准号:
10223258 - 财政年份:2020
- 资助金额:
$ 171.18万 - 项目类别:
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