Advancement of the Xiphophorus Model for Studying Disease

研究疾病的剑尾动物模型的进展

• 批准号: 10805701
• 负责人: Yuan Lu
• 金额: $ 22.59万
• 依托单位: TEXAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10805701
• 关键词: Address; Adult; Ammonia; Anaerobic Bacteria; Animal Experimentation; Animals; Beds; Behavioral; Bioinformatics; Biological; Biological Models; Biomedical Research; Body Size; Cancer Etiology; Chronobiology; Communities; Cryopreservation; Custom; Data; Development; Disease; Embryo; Ensure; Female; Fishes; Generations; Genetic; Genome; Genomics; Growth; Hybrids; Immunologics; Institution; Lead; Link; Manuals; Mechanics; Metabolism; Mission; National Human Genome Research Institute; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Nitrites; Optics; Parasitology; Personal Satisfaction; Physiological; Plants; Production; Protocols documentation; Regulation; Reproducibility; Reproduction; Research; Resources; Sampling; Services; Shock; Stress; Study models; Swimming; System; Texas; Toxicology; United States National Institutes of Health; Universities; Variant; Water; Xiphophorus; aquarium; bioinformatics resource; density; dietary; genetic resource; improved; inter-individual variation; male; meter; model organism; sex determination; sperm cell; trait; ultraviolet; water flow; water quality

Project Summary The Xiphophorus Genetic Stock Center (XGSC) is the only national resource center for the Xiphophorus model system. It provides animals, biological samples, genomics, husbandry, disease and bioinformatics resources to the biomedical research community at large. It resides at Texas State University and has actively served the research community since 1993. Currently, the Xiphophorus are housed in static aquarium of different sizes. While functional, this set up leads to concerns over water quality, and its consistency across different aquariums. Additionally, static water can influence normal Xiphophorus development. We propose to purchase and install a re-circulating system to be used for maintaining and reproducing Xiphophorus to address these issues and aim to improve husbandry conditions for all species housed in the XGSC, in order to strength the rigor and reproducibility of the research animals for the biomedical research community users.

项目摘要 剑尾鱼遗传资源中心（XGSC）是剑尾鱼唯一的国家资源中心。 模型系统它提供动物，生物样品，基因组学，畜牧业，疾病和生物信息学 为整个生物医学研究界提供资源。它位于德克萨斯州立大学， 自1993年以来，积极为研究界服务。目前，剑尾鱼号被安置在 不同大小的水族馆。虽然功能，这一设置导致对水质的关注， 不同水族馆的一致性。此外，静水会影响正常的剑尾鱼 发展我们建议购买和安装一个循环系统，用于维护和 繁殖剑尾鱼以解决这些问题，并旨在改善所有物种的饲养条件 饲养在XGSC中，以加强研究动物的严谨性和重现性， 生物医学研究社区用户。

项目成果

Do Females in a Unisexual-Bisexual Species Complex Differ in Their Behavioral Syndromes and Cortisol Production?

• DOI: 10.3390/biology10030186
• 发表时间: 2021-03-03
• 期刊: Biology
• 影响因子: 4.2
• 作者: Muraco JJ Jr;Monroe DJ;Aspbury AS;Gabor CR
• 通讯作者: Gabor CR

How to manage without a Y chromosome.

• DOI: 10.1073/pnas.2218839120
• 发表时间: 2023-01-10
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Schartl, Manfred;Lamatsch, Dunja K.
• 通讯作者: Lamatsch, Dunja K.

Polygenic sex determination in vertebrates - is there any such thing?

• DOI: 10.1016/j.tig.2022.12.002
• 发表时间: 2023-01
• 期刊: Trends in genetics : TIG
• 作者: M. Schartl;A. Georges;J. A. Marshall Graves