Drug abuse and HIV-associated pulmonary vascular injury
药物滥用和 HIV 相关肺血管损伤
基本信息
- 批准号:10799336
- 负责人:
- 金额:$ 30.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAdministrative SupplementAgeAgingAortaApoptosisAwardBiological AssayBiological MarkersBlood VesselsCardiopulmonaryCardiovascular DiseasesCell AgingCell CommunicationCellsClinicalClinical ResearchClinical TrialsCommunicable DiseasesComplicationCritical CareDataData AnalysesDevelopmentDiagnostic testsDiseaseDrug abuseEchocardiographyEndothelial CellsEndotheliumFunctional disorderFutureGenderGeneral PopulationHIVHealthHumanIndividualInfectionInflammatoryKidneyLaboratoriesLibrariesLightLinkLungMediatingMediatorMicrofluidic MicrochipsMicrofluidicsMolecularMyocardial dysfunctionNanochip Analytical DeviceParentsPathologyPatientsPersonsPhenotypePhysiciansPhysiologicalPlasmaPremature aging syndromePrevalenceProceduresProteinsProteomicsPublishingPulmonary Function Test/Forced Expiratory Volume 1Pulmonary Heart DiseasePulmonary HypertensionPulmonary artery structurePulmonary function testsReportingResearch PersonnelRisk FactorsRoleScienceScientistSmooth MuscleSmooth Muscle MyocytesSpecificityTechnologyTestingTherapeutic InterventionTranslational ResearchUnited States National Institutes of HealthUntranslated RNAVascular DiseasesVascular Endothelial Cellaccurate diagnosticsbiomarker identificationcell typecerebrovascularclinical practicecohortcomorbiditycost effectivedetection platformexperienceextracellular vesiclesfrailtyholistic approachinnovationlung vascular injurynanoengineeringnovelnovel therapeutic interventionpotential biomarkerpreventive interventionprotective effectpulmonary vascular cellspulmonary vascular disorderresponsescreeningsenescenceuser-friendlyvascular injury
项目摘要
Project Summary
This administrative supplement proposal is to examine if the circulating endothelial-derived small
extracellular vesicles (EVs) can be leveraged as a non-invasive biomarker of pulmonary vascular dysfunction
using a novel microfluidic chip-based platform. Lately, EVs have emerged as important mediators in cell-cell
communication, and the role of alterations in their cargo has been implicated in various diseases, including
pulmonary hypertension (PH). However, to allow for rapid integration into clinical practice, there remains a
need for an inexpensive, user-friendly approach to the quantitative analysis of EV-linked putative biomarkers.
So, in this supplement, we intend to leverage a novel microfluidics-based bioanalytical platform to overcome
these technological barriers and the procedure complexity of isolating EVs required for screening large patient
cohorts. Premature aging is one of the important factors contributing to the increased prevalence of
cardiopulmonary diseases in people living with HIV (PWH) and pulmonary vascular endothelial cells have been
reported to be highly senescent in PH. Using a highly sensitive nanoengineered chip-based bioanalytic
platform for the detection of EC-EVs and a targeted proteomics approach, we propose to test the central
hypothesis that the higher numbers of circulating endothelial-derived small EVs (EC-EVs) in PWH carry pro-
aging factors that are associated with an increased prevalence of HIV associated PH. This supplement request
is within the scope of an active parent NIH award on HIV-PH, and the innovative microfluidic approach is
expected to expedite the analysis of a selective sub-population of plasma-derived EVs with increased
sensitivity, specificity, and efficiency. This state-of-the-art technology will also allow for future customization of
new putative EV-linked biomarkers in larger clinical studies. Furthermore, this technology may be adapted in
the future to also identify markers of other vascular pathologies such as frailty and cerebrovascular and renal
pathologies, which are very common in PWH.
项目摘要
本管理补充提案旨在检查循环内皮源性小
细胞外囊泡(EV)可作为肺血管功能障碍的非侵入性生物标志物
使用一种新的微流控芯片平台。近年来,EV已成为细胞-细胞免疫调节的重要介质。
交流,以及货物的改变在各种疾病中的作用,包括
肺动脉高压(PH)。然而,为了允许快速整合到临床实践中,
需要一种廉价的,用户友好的方法来定量分析EV相关的推定生物标志物。
因此,在本补充中,我们打算利用一种新的基于微流体的生物分析平台来克服
这些技术障碍和隔离EV的程序复杂性需要筛查大病人
同伙过早衰老是导致老年痴呆症发病率增加的重要因素之一。
HIV感染者的心肺疾病(PWH)和肺血管内皮细胞已经被
据报道,在PH中高度衰老。使用高度灵敏的基于纳米工程芯片的生物分析
为了检测EC-EV的平台和靶向蛋白质组学方法,我们建议测试中央
假设PWH中循环内皮源性小EV(EC-EV)的数量较高,
老龄化因素与艾滋病毒相关PH的患病率增加有关。本补充要求
是在一个积极的父母NIH奖的范围内对HIV-PH,和创新的微流体方法,
预计将加快对血浆衍生EV的选择性亚群的分析,
灵敏度、特异性和效率。这种最先进的技术还将允许未来定制
在更大规模的临床研究中发现新的推定EV相关生物标志物。此外,该技术可以适用于
未来还将确定其他血管病变的标志物,如虚弱、脑血管和肾脏
这些病症在威尔斯亲王医院非常常见。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Navneet Kaur Dhillon其他文献
Navneet Kaur Dhillon的其他文献
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{{ truncateString('Navneet Kaur Dhillon', 18)}}的其他基金
Drug abuse and HIV-associated pulmonary vascular injury
药物滥用和 HIV 相关肺血管损伤
- 批准号:
10330405 - 财政年份:2021
- 资助金额:
$ 30.21万 - 项目类别:
Drug abuse and HIV-associated pulmonary vascular injury
药物滥用和 HIV 相关肺血管损伤
- 批准号:
10161471 - 财政年份:2021
- 资助金额:
$ 30.21万 - 项目类别:
Drug abuse and HIV-associated pulmonary vascular injury
药物滥用和 HIV 相关肺血管损伤
- 批准号:
10539306 - 财政年份:2021
- 资助金额:
$ 30.21万 - 项目类别:
Impact of Opiate abuse on HIV-mediated Pulmonary Vascular Remodeling
阿片类药物滥用对 HIV 介导的肺血管重塑的影响
- 批准号:
9204520 - 财政年份:2016
- 资助金额:
$ 30.21万 - 项目类别:
Extracellular Vesicles and and HIV/cocaine associated cardiopulmonary dysfunction
细胞外囊泡和 HIV/可卡因相关的心肺功能障碍
- 批准号:
9204218 - 财政年份:2016
- 资助金额:
$ 30.21万 - 项目类别:
Impact of Opiate abuse on HIV-mediated Pulmonary Vascular Remodeling
阿片类药物滥用对 HIV 介导的肺血管重塑的影响
- 批准号:
9115350 - 财政年份:2015
- 资助金额:
$ 30.21万 - 项目类别:
HIV/Cocaine mediated human pulmonary vascular remodeling: Role of BMPR signaling.
HIV/可卡因介导的人肺血管重塑:BMPR 信号传导的作用。
- 批准号:
8410671 - 财政年份:2012
- 资助金额:
$ 30.21万 - 项目类别:
HIV/Cocaine mediated human pulmonary vascular remodeling: Role of BMPR signaling.
HIV/可卡因介导的人肺血管重塑:BMPR 信号传导的作用。
- 批准号:
8508237 - 财政年份:2012
- 资助金额:
$ 30.21万 - 项目类别:
HIV/Cocaine mediated human pulmonary vascular remodeling: Role of BMPR signaling.
HIV/可卡因介导的人肺血管重塑:BMPR 信号传导的作用。
- 批准号:
8653959 - 财政年份:2012
- 资助金额:
$ 30.21万 - 项目类别:
PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
可卡因和 Tat 介导的平滑肌增生中 PDGF 受体的调节
- 批准号:
8231329 - 财政年份:2011
- 资助金额:
$ 30.21万 - 项目类别:
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