Mechanism of leukaemia suppression by the transcription factor Ikaros

转录因子 Ikaros 抑制白血病的机制

• 批准号: nhmrc : 1024599
• 负责人: A/Pr Ross Dickins
• 金额: $ 43.72万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-leukaemia-suppression-factor-ikaros/110364
• 关键词: Mechanism; leukaemia; suppression; transcription; factor

A subset of acute lymphoblastic leukaemias are characterised by mutations in the Ikaros gene. These leukaemias respond poorly to chemotherapy and require novel therapeutic approaches. We have discovered a new function of Ikaros in regulating leukaemia cell death. This project investigates how Ikaros regulates cell death and whether this is a general mechanism. Understanding Ikaros function is a step toward improved treatments for this aggressive type of leukaemia.

急性淋巴细胞白血病的一个亚群以Ikaros基因突变为特征。这些白血病对化疗反应不佳，需要新的治疗方法。我们发现了Ikaros在调节白血病细胞死亡中的新功能。该项目研究Ikaros如何调节细胞死亡，以及这是否是一种通用机制。了解Ikaros的功能是改善这种侵袭性白血病治疗方法的一步。