Investigating tumour maintenance using regulated RNA interference

利用最近发现的被称为RNA干扰（RNAi）的过程来抑制基因表达，可以作为一种实验工具来分析细胞和人类疾病基因工程动物模型中的特定基因。我建议通过使用RNAi来抑制已建立的小鼠肿瘤中的特定基因来验证癌症中潜在的药物靶点。进一步的目标是利用RNAi在小鼠癌症模型中模拟人类癌症基因突变，以发现新的肿瘤抑制基因。

Inhibiting gene expression using the recently discovered process known as RNA interference (RNAi) can be used as an experimental tool to analyse specific genes, in cells and genetically engineered animal models of human disease. I propose to validate potential drug targets in cancer by using RNAi to inhibit specific genes in established mouse tumours. A further aim is to use RNAi to mimic human cancer gene mutations in mouse cancer models, to discover novel tumour suppressor genes.