Investigating tumour maintenance using regulated RNA interference

使用受调控的 RNA 干扰研究肿瘤维持

• 批准号: nhmrc : 575573
• 负责人: A/Pr Ross Dickins
• 金额: $ 34.09万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-tumour-maintenance-rna-interference/97725
• 关键词: Investigating; tumour; maintenance; using; regulated

Inhibiting gene expression using the recently discovered process known as RNA interference (RNAi) can be used as an experimental tool to analyse specific genes, in cells and genetically engineered animal models of human disease. I propose to validate potential drug targets in cancer by using RNAi to inhibit specific genes in established mouse tumours. A further aim is to use RNAi to mimic human cancer gene mutations in mouse cancer models, to discover novel tumour suppressor genes.

使用最近发现的被称为RNA干扰(RNAi)的过程来抑制基因表达，可以作为一种实验工具来分析特定的基因，在细胞和人类疾病的基因工程动物模型中。我建议通过使用RNAi抑制已建立的小鼠肿瘤中的特定基因来验证癌症的潜在药物靶点。另一个目的是利用RNAi在小鼠癌症模型中模拟人类癌症基因突变，发现新的肿瘤抑制基因。