Overcoming the differentiation block in acute myeloid leukaemia

克服急性髓系白血病的分化障碍

• 批准号: nhmrc : 1121765
• 负责人: A/Pr Ross Dickins
• 金额: $ 55.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/overcoming-differentiation-block-myeloid-leukaemia/946804
• 关键词: Overcoming; differentiation; block; acute; myeloid

Acute myeloid leukaemia (AML) is an aggressive leukaemia with poor overall survival. About 50% of AML cases have genetic mutations that disable PU.1, which in turn alters the expression of many other genes that cause leukaemia. We have developed new AML models allowing reversible inhibition of PU.1, and have shown that re-engaging PU.1 function causes AML regression. This project aims to understand PU.1 functions in AML and identify rational drug targets for treatment-resistant disease.

急性髓性白血病（AML）是一种侵袭性白血病，总生存率低。大约50%的AML病例具有使PU.1失效的基因突变，这反过来改变了导致白血病的许多其他基因的表达。我们已经开发了新的AML模型，允许可逆抑制PU.1，并表明重新参与PU.1功能会导致AML消退。该项目旨在了解PU.1在AML中的功能，并确定耐药疾病的合理药物靶点。