University of Louisville Center for Integrative Environmental Health Sciences

路易斯维尔大学综合环境健康科学中心

• 批准号: 10817400
• 负责人: J CHRISTOPHER STATES
• 金额: $ 14.69万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10817400
• 关键词: Adult; Agriculture; Alcohol consumption; Alcohols; Area; Basic Science; Biological Models; Biometry; Cardiovascular system; Chemicals; Childhood; Chronic; Chronic Disease; Clinical; Clinical Trials; Clinical Trials Unit; Collaborations; Communication; Communities; Complex; Core Facility; County; Development; Diabetes Mellitus; Diet; Disease; Disease Outcome; Ecosystem; Education; Environment; Environmental Health; Environmental Risk Factor; Etiology; Exposure to; Funding; Gender; Genetic; Genetic Predisposition to Disease; Genotype; Geographic Locations; Goals; Grant; Health; Health Personnel; Health Sciences; Human; Individual; Industrialization; Informatics; Interdisciplinary Study; Interest Group; Intervention; Investigation; Kentucky; Knowledge; Laboratories; Leadership; Life; Life Style; Malignant Neoplasms; Measurement; Mental disorders; Mentors; Mentorship; Metals; Modification; Obesity; Organ; Pathogenesis; Persons; Pilot Projects; Play; Pollution; Polychlorinated Biphenyls; Positioning Attribute; Predisposition; Prevention strategy; Program Development; Research; Research Personnel; Resources; Role; Rural; Strategic vision; Toxic Environmental Substances; Toxicant exposure; Toxicology; Training; Translating; Translations; United States; Universities; Vinyl Chloride; Youth; addiction; built environment; career development; citizen science; community based participatory research; community based research; community engagement; design; health science research; improved; lifestyle factors; man; member; metropolitan; multidisciplinary; next generation; pollutant; programs; recruit; response; rural environment; rural healthcare; skills; socioeconomics; stressor; tobacco exposure; tobacco products; toxicant interaction; urban setting

The University of Louisville’s (UofL) Center for Integrative Environmental Health Science (CIEHS) brings together a multidisciplinary group of investigators working together to develop a framework to understand the complexities of and to integrate the interactions between environmental toxicants, life style factors, life stage, genetics and gender and their roles in human health and disease. The CIEHS is uniquely positioned to build transdisciplinary teams to tackle these problems by virtue of the multidisciplinary expertise of its members and its geographic location. The Louisville Regional Community, composed of Metropolitan Louisville and the counties of western Kentucky, is a unique mix of urban and rural environments with industrial and agricultural exposures that is a microcosm of the United States. The region is plagued by rates of chronic disease (e.g. cardiovascular, diabetes, cancer, etc.), all with environmental etiologies, that are among the highest in the nation. The CIEHS facilitates research and training focused on: (1) exposure to industrial chemicals present in the urban and rural KY environments (metals, VOCs, PCBs, vinyl chloride, etc.), (2) lifestyle factors (diet, alcohol, socioeconomic stressors, obesity, etc.), and the modifications to response by life stage, genetics and gender in development of chronic adult diseases. CIEHS is organized into three multi-disciplinary research interest groups (multi-organ toxicology, cancer, and neurodevelopmental toxicology). The Integrated Health Science Facility Core promotes translation of basic science including assistance with both adult and pediatric clinical trials. The Community Engagement Core promotes multi-directional communication between CIEHS investigators and community groups with special focus on rural health care providers and youth groups. The Pilot Project Program provides resources supporting new environmental health investigators, collaborations between CIEHS members and established investigators bringing new skill sets to environmental health problems, new avenues of environmental health research by CIEHS members, and community-engaged and community-led research in collaboration with CIEHS members. A Career Development Program provides mentorship and support to new junior, as well as mid-level, investigators. These activities are supported by two facility cores (biostatistics and informatics, and integrated toxicomics and environmental measurements). The CIEHS provides leadership in environmental health research, promotes investigation of the interactions of chronic exposure to environmental toxicants and lifestyle factors in pathogenesis, and develops the next generation of environmental health researchers. Our studies utilize model systems in the laboratory, the larger ecosystem by investigation of pollution effects on wildlife, and the human laboratory provided by the Louisville Regional Community in collaboration with community partners.

路易斯维尔大学（UofL）综合环境健康科学中心（CIEHS） 一个多学科的研究小组共同努力，制定一个框架，以了解 综合环境毒物、生活方式因素、生命阶段、 遗传学和性别及其在人类健康和疾病中的作用。CIEHS的独特定位是建立 跨学科小组，凭借其成员的多学科专门知识解决这些问题， 它的地理位置。路易斯维尔地区社区，由大都会路易斯维尔和 美国肯塔基州西部的一个县，是一个独特的城市和农村环境与工业和农业的混合体 这是美国的缩影。该地区受到慢性病发病率的困扰（例如， 心血管、糖尿病、癌症等），都是由环境因素引起的， 民族CIEHS促进研究和培训，重点是：（1）接触工业化学品， 城市和农村KY环境（金属、VOC、PCB、氯乙烯等），(2)生活方式因素（饮食， 酒精、社会经济压力、肥胖等），以及对生命阶段、遗传学和 性别在慢性成人疾病发展中的作用。CIEHS分为三个多学科研究 兴趣小组（多器官毒理学、癌症和神经发育毒理学）。综合卫生 科学设施核心促进基础科学的翻译，包括成人和儿科的援助 临床试验社区参与核心促进CIEHS之间的多方位沟通 调查人员和社区团体，特别关注农村保健提供者和青年团体。的 试点项目计划提供资源，支持新的环境健康调查人员，合作 CIEHS成员与为环境健康带来新技能的资深调查员之间的合作 问题，CIEHS成员的环境健康研究的新途径，以及社区参与和 与CIEHS成员合作开展社区主导的研究。职业发展计划提供 为新的初级和中级调查员提供辅导和支助。这些活动得到两个机构的支持。 设施核心（生物统计学和信息学，以及综合毒理学和环境测量）。的 CIEHS在环境健康研究方面发挥领导作用，促进对环境与健康之间相互作用的调查。 慢性暴露于环境毒物和生活方式因素的发病机制，并发展下 环境卫生研究人员的一代。我们的研究在实验室中利用模型系统， 通过调查污染对野生动物的影响，以及路易斯维尔提供的人类实验室， 与社区伙伴合作的区域社区。