University of Louisville Center for Integrative Environmental Health Sciences

路易斯维尔大学综合环境健康科学中心

基本信息

批准号：
10560120
负责人：
J CHRISTOPHER STATES
金额：
$ 17.21万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10560120
关键词：
Address Adult Agriculture Alcoholic Fatty Liver Alcohols Animals Basic Science Biochemical Biological Assay Biological Models Biometry Blood Cardiovascular system Cell Cycle Cells Center Core Grants Chemicals Childhood Chromosomal Instability Chronic Chronic Disease Clinical Trials Collaborations Communication Communities Core Facility County Data Development Diabetes Mellitus Diet Disease Disease Outcome Disease Progression Doctor of Philosophy Ecosystem Educational process of instructing Environment Environmental Hazards Environmental Health Environmental Pollutants Etiology Exposure to Fatty Liver Foundations Funding Future Gender Genetic Geographic Locations Goals Growth Health Health Personnel Health Sciences Hepatic Hepatocyte High Fat Diet High School Student Human Industrialization Informatics Interdisciplinary Study Interest Group Investigation Kentucky Knowledge Laboratories Leadership Life Lipids Liver Liver diseases Malignant Neoplasms Measurement Measures Medicine Mentors Mentorship Metabolic Metals Modification Morbidity - disease rate National Institute of Environmental Health Sciences Neoplastic Cell Transformation Obesity Organ Outcome Pathogenesis Pathologic Persons Pilot Projects Pollution Poly-fluoroalkyl substances Polychlorinated Biphenyls Positioning Attribute Predisposition Prevalence Primary carcinoma of the liver cells Program Development Public Health Rattus Research Research Personnel Research Training Resources Risk Assessment Risk Factors Risk Management Role Rural Rural Community Severity of illness Testing Tissues Toxic Environmental Substances Toxicology Training Translations United States Universities Vinyl Chloride Youth career development chromium hexavalent ion chronic liver disease citizen science community based participatory research community based research community engagement community involvement drinking water environmental toxicology epidemiologic data epidemiology study experience fatty liver disease human disease improved in vivo Model lifestyle factors lipid metabolism member metropolitan mortality multidisciplinary neoplastic next generation non-alcoholic fatty liver disease novel parent grant pollutant interaction preventive intervention programs ranpirnase recruit response rural environment rural healthcare simple steatosis skills socioeconomics stressor urban setting voucher

项目摘要

PROJECT SUMMARY OF THE FUNDED PARENT GRANT The University of Louisville’s (UofL) Center for Integrative Environmental Health Science (CIEHS) brings together a multidisciplinary group of investigators working together to develop a framework to understand the complexities of and to integrate the interactions between environmental toxicants, life style factors, life stage, genetics and gender and their roles in human health and disease. The CIEHS is uniquely positioned to build transdisciplinary teams to tackle these problems by virtue of the multidisciplinary expertise of its members and its geographic location. The Louisville Regional Community, composed of Metropolitan Louisville and the counties of western Kentucky, is a unique mix of urban and rural environments with industrial and agricultural exposures that is a microcosm of the United States. The region is plagued by rates of chronic disease (e.g. cardiovascular, diabetes, cancer, etc.), all with environmental etiologies, that are among the highest in the nation. The CIEHS facilitates research and training focused on: (1) exposure to industrial chemicals present in the urban and rural KY environments (metals, VOCs, PCBs, vinyl chloride, etc.), (2) lifestyle factors (diet, alcohol, socioeconomic stressors, obesity, etc.), and the modifications to response by life stage, genetics and gender in development of chronic adult diseases. CIEHS is organized into three multi-disciplinary research interest groups (multi-organ toxicology, cancer, and neurodevelopmental toxicology). The Integrated Health Science Facility Core promotes translation of basic science including assistance with both adult and pediatric clinical trials. The Community Engagement Core promotes multi-directional communication between CIEHS investigators and community groups with special focus on rural health care providers and youth groups. The Pilot Project Program provides resources supporting new environmental health investigators, collaborations between CIEHS members and established investigators bringing new skill sets to environmental health problems, new avenues of environmental health research by CIEHS members, and community-engaged and community-led research in collaboration with CIEHS members. A Career Development Program provides mentorship and support to new junior, as well as mid-level, investigators. These activities are supported by two facility cores (biostatistics and informatics, and integrated toxicomics and environmental measurements). The CIEHS provides leadership in environmental health research, promotes investigation of the interactions of chronic exposure to environmental toxicants and lifestyle factors in pathogenesis, and develops the next generation of environmental health researchers. Our studies utilize model systems in the laboratory, the larger ecosystem by investigation of pollution effects on wildlife, and the human laboratory provided by the Louisville Regional Community in collaboration with community partners.

资助父母赠款的项目摘要路易斯维尔大学（UOFL）综合环境健康科学中心（CIEHS）汇集了一个跨学科的研究人员共同努力开发一个框架以了解复杂性的并整合环境有毒物质，生活方式因素，生命阶段，遗传学和性别及其在人类健康和疾病中的作用。 CIEHS独特地定位在建造跨学科团队通过其成员的多学科专业知识来解决这些问题及其地理地点。路易斯维尔地区社区，由大都会路易斯维尔和西方县组成肯塔基州是城市和粗糙环境与工业和农业暴露的独特组合美国的缩影。该地区受到慢性疾病率的困扰（例如心血管，糖尿病，癌症等），全国最高的环境病因。 CIEHS的最爱研究和培训的重点是：（1）肯塔基州和农村地区存在的工业化学物质环境（金属，VOC，PCB，氯化乙烯基等），（2）生活方式因素（饮食，酒精，社会经济压力源，肥胖等），以及对生命阶段，遗传学和发展的反应的修改慢性成人疾病。 CIEHS分为三个多学科研究兴趣小组（多器官毒理学，癌症和神经发育毒理学）。综合健康科学设施核心促进基础科学的翻译，包括对成人和小儿临床试验的帮助。社区参与核心促进CIEHS调查人员与社区之间的多向沟通特别关注粗糙的医疗保健提供者和青年团体的小组。试点项目提供支持新的环境健康调查人员的资源，CIEHS成员之间的合作既定的调查人员将新技能设置带入环境健康问题，这是 CIEHS成员的环境健康研究，以及社区参与和社区主导的研究与CIEHS成员合作。一项职业发展计划为新的人提供精神和支持大三和中层调查人员。这些活动得到了两个设施核心的支持（生物统计学和信息信息，综合毒理和环境测量）。 CIEHS在环境健康研究，促进长期暴露于环境的相互作用的投资发病机理中的有毒物质和生活方式因素，并发展下一代环境健康研究人员。我们的研究利用实验室中的模型系统，通过投资污染对野生动植物的影响，以及路易斯维尔地区社区提供的人类实验室与社区合作伙伴合作。