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University of Louisville Center for Integrative Environmental Health Sciences

路易斯维尔大学综合环境健康科学中心

基本信息

批准号：
10560120
负责人：
J CHRISTOPHER STATES
金额：
$ 17.21万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10560120
关键词：
Address Adult Agriculture Alcoholic Fatty Liver Alcohols Animals Basic Science Biochemical Biological Assay Biological Models Biometry Blood Cardiovascular system Cell Cycle Cells Center Core Grants Chemicals Childhood Chromosomal Instability Chronic Chronic Disease Clinical Trials Collaborations Communication Communities Core Facility County Data Development Diabetes Mellitus Diet Disease Disease Outcome Disease Progression Doctor of Philosophy Ecosystem Educational process of instructing Environment Environmental Hazards Environmental Health Environmental Pollutants Etiology Exposure to Fatty Liver Foundations Funding Future Gender Genetic Geographic Locations Goals Growth Health Health Personnel Health Sciences Hepatic Hepatocyte High Fat Diet High School Student Human Industrialization Informatics Interdisciplinary Study Interest Group Investigation Kentucky Knowledge Laboratories Leadership Life Lipids Liver Liver diseases Malignant Neoplasms Measurement Measures Medicine Mentors Mentorship Metabolic Metals Modification Morbidity - disease rate National Institute of Environmental Health Sciences Neoplastic Cell Transformation Obesity Organ Outcome Pathogenesis Pathologic Persons Pilot Projects Pollution Poly-fluoroalkyl substances Polychlorinated Biphenyls Positioning Attribute Predisposition Prevalence Primary carcinoma of the liver cells Program Development Public Health Rattus Research Research Personnel Research Training Resources Risk Assessment Risk Factors Risk Management Role Rural Rural Community Severity of illness Testing Tissues Toxic Environmental Substances Toxicology Training Translations United States Universities Vinyl Chloride Youth career development chromium hexavalent ion chronic liver disease citizen science community based participatory research community based research community engagement community involvement drinking water environmental toxicology epidemiologic data epidemiology study experience fatty liver disease human disease improved in vivo Model lifestyle factors lipid metabolism member metropolitan mortality multidisciplinary neoplastic next generation non-alcoholic fatty liver disease novel parent grant pollutant interaction preventive intervention programs ranpirnase recruit response rural environment rural healthcare simple steatosis skills socioeconomics stressor urban setting voucher

项目摘要

PROJECT SUMMARY OF THE FUNDED PARENT GRANT The University of Louisville’s (UofL) Center for Integrative Environmental Health Science (CIEHS) brings together a multidisciplinary group of investigators working together to develop a framework to understand the complexities of and to integrate the interactions between environmental toxicants, life style factors, life stage, genetics and gender and their roles in human health and disease. The CIEHS is uniquely positioned to build transdisciplinary teams to tackle these problems by virtue of the multidisciplinary expertise of its members and its geographic location. The Louisville Regional Community, composed of Metropolitan Louisville and the counties of western Kentucky, is a unique mix of urban and rural environments with industrial and agricultural exposures that is a microcosm of the United States. The region is plagued by rates of chronic disease (e.g. cardiovascular, diabetes, cancer, etc.), all with environmental etiologies, that are among the highest in the nation. The CIEHS facilitates research and training focused on: (1) exposure to industrial chemicals present in the urban and rural KY environments (metals, VOCs, PCBs, vinyl chloride, etc.), (2) lifestyle factors (diet, alcohol, socioeconomic stressors, obesity, etc.), and the modifications to response by life stage, genetics and gender in development of chronic adult diseases. CIEHS is organized into three multi-disciplinary research interest groups (multi-organ toxicology, cancer, and neurodevelopmental toxicology). The Integrated Health Science Facility Core promotes translation of basic science including assistance with both adult and pediatric clinical trials. The Community Engagement Core promotes multi-directional communication between CIEHS investigators and community groups with special focus on rural health care providers and youth groups. The Pilot Project Program provides resources supporting new environmental health investigators, collaborations between CIEHS members and established investigators bringing new skill sets to environmental health problems, new avenues of environmental health research by CIEHS members, and community-engaged and community-led research in collaboration with CIEHS members. A Career Development Program provides mentorship and support to new junior, as well as mid-level, investigators. These activities are supported by two facility cores (biostatistics and informatics, and integrated toxicomics and environmental measurements). The CIEHS provides leadership in environmental health research, promotes investigation of the interactions of chronic exposure to environmental toxicants and lifestyle factors in pathogenesis, and develops the next generation of environmental health researchers. Our studies utilize model systems in the laboratory, the larger ecosystem by investigation of pollution effects on wildlife, and the human laboratory provided by the Louisville Regional Community in collaboration with community partners.

获资助父母奖助金之计划摘要