12th Annual Midwest DNA Repair Symposium

描述(由申请人提供)：第12届中西部DNA修复研讨会(AMDRS)将于2010年5月15日至16日在肯塔基州路易斯维尔大学谢尔比校区举行。AMDRS于1999年在密歇根大学安娜堡分校成立，此后每年都会在中西部的多所大学举行会议。中西部DNA修复研讨会最初被设想为一个论坛，每年将来自中西部地区的DNA修复研究人员聚集在一起，讨论正在进行的研究并鼓励合作。AMDRS的其他目标包括使参加研讨会的费用尽可能低，并让年轻的研究人员、博士后研究员和研究生优先在口头和海报会议上介绍他们的工作。DNA修复是一个基本的细胞过程，对维持基因组完整性和人类健康至关重要。DNA修复功能障碍与许多遗传性疾病以及神经变性、心血管疾病、衰老和癌症等慢性疾病有关。调查人员感到高兴的是，这一系列研讨会非常成功，在过去几年中出席人数大幅增加。成功的关键之一是将出席的成本保持在较低水平。这一低成本之所以成为可能，是因为每年的组织者都在各自的机构举办研讨会，并获得了内部和外部资金，以支付一些主要费用。特别是在资金紧张的时候，AMDRS是一次会议，PI能够带着他们的学生和博士后研究员与该领域的领先科学家互动，并在同行中展示他们的工作。AMDRS现在进入了第二个十年，已经开始循环使用。2010年，AMDRS将重返路易斯维尔。AMDRS的三个主要目标：1)为主要来自中西部各州的科学家提供一个场所，介绍和讨论DNA损伤、修复和突变领域的当前研究，并提供促进科学合作的机会。(2)为学生、博士后研究员和开始独立研究的人提供机会，向同行介绍他们的工作，并与该领域的领导人互动。(3)通过让这些研讨会负担得起来提供额外的价值。 与公共卫生相关：造成DNA损伤的环境因素有助于包括癌症、心血管和神经退行性疾病在内的慢性人类疾病的发展和进展。DNA修复是消除DNA损伤的重要细胞过程，有效的DNA修复是预防这些慢性疾病的关键。这次研讨会将把DNA修复研究人员聚集在一起，讨论他们的最新研究，交流思想，发展新的合作。

DESCRIPTION (provided by applicant): The 12th Annual Midwest DNA Repair Symposium (AMDRS) will take place in Louisville, KY on May 15 - 16, 2010 at the Shelby Campus of the University of Louisville. The AMDRS started in 1999 at the University of Michigan - Ann Arbor and has met at various universities in the Midwest every year since then. The Midwest DNA Repair Symposium was originally conceived as a forum to bring together DNA repair researchers from the Midwestern region on an annual basis to discuss ongoing research and to stimulate collaborations. Additional goals of the AMDRS include making the cost of attending the symposium as inexpensive as possible and to provide young investigators, postdoctoral fellows and graduate students priority in presenting their work in oral and poster sessions. DNA repair is a fundamental cellular process critical to maintenance of genome integrity and human health. DNA repair dysfunction has been linked with many inherited diseases as well as chronic diseases such as neurodegeneration, cardiovascular disease, aging and cancer. The investigators are pleased that this symposia series has been very successful and has seen significant increase in attendance the past several years. One key to the success has been to keep the costs of attendance low. This low cost has been possible because the organizers for each year held the symposium at their home institutions and have secured both intramural and extramural funding to cover some of the major expenses. Especially in times of restricted funding, the AMDRS is one meeting to which PI's have been able to bring their students and post-doctoral fellows to interact with leading scientists in the field and to present their work among peers. The AMDRS is now in its second decade and has started to recycle. In 2010, the AMDRS is returning to Louisville. The three principle goals of the AMDRS: 1) to provide a venue for scientists mainly from the Midwestern states, to present and discuss current research in the field of DNA damage, repair and mutagenesis, and to provide opportunities to foster scientific collaborations. (2) To provide students, postdoctoral fellows, and beginning independent investigators the opportunity to p resent their work to peers and to interact with leaders in the field. (3) To provide an exceptional value of these symposia by keeping them affordable. PUBLIC HEALTH RELEVANCE: Environmental agents that cause DNA damage contribute to the development and progression of chronic human disease including cancer, and cardiovascular and neurodegenerative diseases. DNA repair is an essential cellular processes that removes the DNA damage and efficient DNA repair is essential to prevention of these chronic diseases. This symposium will bring together DNA repair researchers to discuss their newest research, to exchange ideas and to develop new collaborations.