University of Louisville Center for Integrative Environmental Health Sciences

路易斯维尔大学综合环境健康科学中心

• 批准号: 10600111
• 负责人: J CHRISTOPHER STATES
• 金额: $ 133.03万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600111
• 关键词: Adult; Agriculture; Alcohol consumption; Alcohols; Area; Basic Science; Biological Models; Biometry; Cardiovascular system; Chemicals; Childhood; Chronic; Chronic Disease; Clinical; Clinical Trials; Clinical Trials Unit; Collaborations; Communication; Communities; Complex; Core Facility; County; Development; Diabetes Mellitus; Diet; Disease; Disease Outcome; Ecosystem; Education; Environment; Environmental Health; Environmental Risk Factor; Etiology; Exposure to; Funding; Gender; Genetic; Genetic Predisposition to Disease; Genotype; Geographic Locations; Goals; Grant; Health; Health Personnel; Health Sciences; Human; Individual; Industrialization; Informatics; Interdisciplinary Study; Interest Group; Intervention; Investigation; Kentucky; Knowledge; Laboratories; Leadership; Life; Life Style; Malignant Neoplasms; Measurement; Mental disorders; Mentors; Mentorship; Metals; Modification; Obesity; Organ; Pathogenesis; Persons; Pilot Projects; Play; Pollution; Polychlorinated Biphenyls; Positioning Attribute; Predisposition; Prevention strategy; Program Development; Research; Research Personnel; Resources; Role; Rural; Strategic vision; Toxic Environmental Substances; Toxicant exposure; Toxicology; Training; Translating; Translations; United States; Universities; Vinyl Chloride; Youth; addiction; built environment; career development; citizen science; community based participatory research; community based research; community engagement; design; health science research; improved; lifestyle factors; man; member; metropolitan; multidisciplinary; next generation; pollutant; programs; recruit; response; rural environment; rural healthcare; skills; socioeconomics; stressor; tobacco exposure; tobacco products; toxicant interaction; urban setting

The University of Louisville’s (UofL) Center for Integrative Environmental Health Science (CIEHS) brings together a multidisciplinary group of investigators working together to develop a framework to understand the complexities of and to integrate the interactions between environmental toxicants, life style factors, life stage, genetics and gender and their roles in human health and disease. The CIEHS is uniquely positioned to build transdisciplinary teams to tackle these problems by virtue of the multidisciplinary expertise of its members and its geographic location. The Louisville Regional Community, composed of Metropolitan Louisville and the counties of western Kentucky, is a unique mix of urban and rural environments with industrial and agricultural exposures that is a microcosm of the United States. The region is plagued by rates of chronic disease (e.g. cardiovascular, diabetes, cancer, etc.), all with environmental etiologies, that are among the highest in the nation. The CIEHS facilitates research and training focused on: (1) exposure to industrial chemicals present in the urban and rural KY environments (metals, VOCs, PCBs, vinyl chloride, etc.), (2) lifestyle factors (diet, alcohol, socioeconomic stressors, obesity, etc.), and the modifications to response by life stage, genetics and gender in development of chronic adult diseases. CIEHS is organized into three multi-disciplinary research interest groups (multi-organ toxicology, cancer, and neurodevelopmental toxicology). The Integrated Health Science Facility Core promotes translation of basic science including assistance with both adult and pediatric clinical trials. The Community Engagement Core promotes multi-directional communication between CIEHS investigators and community groups with special focus on rural health care providers and youth groups. The Pilot Project Program provides resources supporting new environmental health investigators, collaborations between CIEHS members and established investigators bringing new skill sets to environmental health problems, new avenues of environmental health research by CIEHS members, and community-engaged and community-led research in collaboration with CIEHS members. A Career Development Program provides mentorship and support to new junior, as well as mid-level, investigators. These activities are supported by two facility cores (biostatistics and informatics, and integrated toxicomics and environmental measurements). The CIEHS provides leadership in environmental health research, promotes investigation of the interactions of chronic exposure to environmental toxicants and lifestyle factors in pathogenesis, and develops the next generation of environmental health researchers. Our studies utilize model systems in the laboratory, the larger ecosystem by investigation of pollution effects on wildlife, and the human laboratory provided by the Louisville Regional Community in collaboration with community partners.

路易斯维尔大学 (UofL) 综合环境健康科学中心 (CIEHS) 带来了 由多学科研究人员组成的小组共同开发一个框架来理解 复杂性并整合环境毒物、生活方式因素、生命阶段之间的相互作用， 遗传学和性别及其在人类健康和疾病中的作用。 CIEHS 具有得天独厚的优势： 跨学科团队凭借其成员的多学科专业知识来解决这些问题 它的地理位置。路易斯维尔地区社区，由路易斯维尔大都市和 肯塔基州西部的县，是城市和乡村环境与工业和农业的独特结合 曝光是美国的一个缩影。该地区深受慢性病发病率的困扰（例如慢性病）。 心血管、糖尿病、癌症等），所有这些都与环境病因有关，是人类中最高的 国家。 CIEHS 促进以下方面的研究和培训：(1) 接触工业化学品 城乡KY环境（金属、VOCs、PCBs、氯乙烯等），（2）生活方式因素（饮食、 酒精、社会经济压力、肥胖等），以及根据生命阶段、遗传和基因对反应的修改 慢性成人疾病发展中的性别。 CIEHS 分为三个多学科研究 兴趣小组（多器官毒理学、癌症和神经发育毒理学）。综合健康 科学设施核心促进基础科学的转化，包括为成人和儿童提供援助 临床试验。社区参与核心促进CIEHS之间的多向沟通 调查人员和社区团体，特别关注农村卫生保健提供者和青年团体。这 试点项目计划提供支持新的环境健康调查人员和合作的资源 CIEHS 成员和知名研究人员之间的合作为环境健康带来了新的技能 问题、CIEHS 成员环境健康研究的新途径以及社区参与和 与 CIEHS 成员合作进行社区主导的研究。职业发展计划提供 对新的初级和中级研究人员的指导和支持。这些活动得到了两个机构的支持 设施核心（生物统计学和信息学，以及综合毒理学和环境测量）。这 CIEHS 在环境健康研究方面发挥领导作用，促进对环境相互作用的调查 慢性暴露于环境毒物和生活方式因素的发病机制，并发展出下一个 一代环境健康研究人员。我们的研究利用实验室中的模型系统 通过调查污染对野生动物的影响来调查生态系统，以及路易斯维尔提供的人类实验室 区域社区与社区合作伙伴合作。