Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools: Antibodies Supplement

非人类灵长类动物体细胞基因组编辑工具评估测试中心：抗体补充​​剂

• 批准号: 10827650
• 负责人: DENNIS J. HARTIGAN-O'CONNOR
• 金额: $ 24.12万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-14 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10827650
• 关键词: Acceleration; Antibodies; California; Center for Translational Science Activities; Clinical Sciences; Collaborations; Communities; Ensure; Evaluation; Fostering; Future; Genome; Infrastructure; Primates; Research; Research Personnel; Resources; Technology; Testing; Translations; gene therapy; genome editing; human disease; nonhuman primate; somatic cell gene editing; support tools; synergism; tool

PROJECT SUMMARY / ABSTRACT The Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools supports studies with nonhuman primates that will advance the genome editing field, and significantly contributes to the future translation of these technologies for the treatment of human disease. The Nonhuman Primate Testing Center includes a robust team and partnerships that capitalize on major strengths including the California National Primate Research Center, Genome Center, and Clinical and Translational Science Center. The Nonhuman Primate Testing Center offers state-of-the-art capabilities for Somatic Cell Genome Editing (SCGE) investigators to conduct high quality research in nonhuman primates. The Testing Center leverages a supportive framework that has demonstrated a long-standing commitment to providing research opportunities and collaborations to investigators nationwide. Through this powerful infrastructure the Testing Center fosters partnerships with SCGE awardees through provision of expertise, resources, and collaborative opportunities that accelerate their research, and ensures synergism across the SCGE Consortium and with ongoing interactions with the Dissemination and Coordinating Center. This supplement supports a key collaborative project that will result in new opportunities with broad applications for the gene therapy and somatic cell genome editing fields, and will be conducted utilizing all of the capabilities of the Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools.

项目摘要 /摘要 躯体细胞基因组编辑工具评估的非人类灵长类动物测试中心支持研究 有了非人类灵长类动物，将推进基因组编辑领域，并为未来做出重大贡献 这些技术治疗人类疾病的翻译。非人类灵长类动物测试中心 包括一个强大的团队和合作伙伴关系，利用包括加利福尼亚国家在内的主要优势 灵长类动物研究中心，基因组中心以及临床和转化科学中心。非人类 灵长类动物测试中心为体细胞基因组编辑（SCGE）提供了最先进的功能 研究人员在非人类灵长类动物中进行高质量研究。测试中心利用 支持框架，这表明了为提供研究机会的长期承诺 以及全国调查人员的合作。通过这个强大的基础架构，测试中心养育了 通过提供专业知识，资源和协作机会，与SCGE获奖者的合作伙伴关系 这加速了他们的研究，并确保了整个SCGE财团的协同作用以及持续的 与传播和协调中心的相互作用。这种补充支持关键协作 将为基因疗法和体细胞的广泛应用带来新的机会的项目 基因组编辑场，并将使用非人类灵长类动物测试的所有能力进行 体细胞基因组编辑工具评估中心。