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Center for Somatic Cell Genome Editing in Nonhuman Primates

非人类灵长类体细胞基因组编辑中心

基本信息

批准号：
10773947
负责人：
DENNIS J. HARTIGAN-O'CONNOR
金额：
$ 134.13万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10773947
关键词：
Acceleration Address Adult Animal Model Animal Testing Animals Benchmarking Biological Biological Assay Biological Models California Center for Translational Science Activities Clinical Sciences Clinical Trials Collaborations Communication Communities Development Disease model Emerging Technologies Ensure Evaluation Feedback Fostering Future Genome Goals Governing Board Human Inflammation Infrastructure Leadership Letters Longevity Methodology Modeling Office of Administrative Management Patients Positioning Attribute Preclinical Testing Primates Procedures Process Productivity Reagent Reporter Research Research Personnel Research Priority Resources Role Safety Schedule Scientist Services Specificity System Techniques Technology Testing Therapeutic Translational Research Translations United States National Institutes of Health Work age group data exchange data sharing empowerment experience fetal gene therapy genome editing home test human disease immunogenicity innovation meetings multidisciplinary new technology nonhuman primate organizational structure outreach pre-clinical research prenatal programs somatic cell gene editing synergism therapeutic genome editing tool

项目摘要

Overall PROJECT SUMMARY / ABSTRACT The Center for Somatic Cell Genome Editing in Nonhuman Primates will fully support studies that will advance the somatic cell genome editing field, and significantly contribute to the future translation of new and emerging technologies for the treatment of human diseases. The Nonhuman Primate Testing Center brings together a robust team of multidisciplinary investigators with partnerships that capitalize on major strengths at UC Davis including the California National Primate Research Center, Genome Center, and Clinical and Translational Science Center. The program will provide unique state-of-the-art capabilities for investigators to conduct high-quality research in nonhuman primates. The Nonhuman Primate Testing Center leverages a supportive framework that has demonstrated a long-standing commitment to outreach and providing collaborative opportunities to investigators nationwide to advance their translational preclinical research goals, including progression to human clinical trials. Through this powerful and proven infrastructure, the Center for Somatic Cell Genome Editing in Nonhuman Primates will address the following Specific Aims: (1) Provide an administrative and organizational structure to advance somatic cell genome editing studies targeting a range of human diseases in all age groups, (2) Partner with investigators to accelerate their translational research objectives, and (3) Ensure synergism and sharing across the small and large animal testing centers and transparent interactions with the research community and the NIH. Our robust multidisciplinary team is poised to continue our national role and service to the research community by bringing the depth and breadth of opportunities available to support investigators, and safely advance somatic cell genome editing technologies to new treatments for human diseases.

整体项目总结/摘要非人类灵长类体细胞基因组编辑中心将全力支持以下研究：推进体细胞基因组编辑领域，并为未来翻译新的和治疗人类疾病的新兴技术。非人类灵长类动物检测中心由多学科调查人员组成的强大团队与利用主要优势的合作伙伴一起，加州大学戴维斯分校，包括加州国家灵长类动物研究中心，基因组中心，临床和翻译科学中心。该计划将为调查人员提供独特的最先进的能力，在非人类灵长类动物身上进行高质量的研究。非人类灵长类动物检测中心利用支持性框架，表明长期致力于外联和提供为全国范围内的研究者提供合作机会，以推进他们的转化临床前研究目标，包括人类临床试验的进展。通过这一功能强大且经过验证的基础设施，非人灵长类动物中的体细胞基因组编辑将解决以下具体目标：（1）提供一种用于非人灵长类动物的体细胞基因组编辑方法。推进体细胞基因组编辑研究的行政和组织结构，所有年龄组的人类疾病，（2）与研究人员合作，加速他们的转化研究（3）确保小型和大型动物试验中心之间的协同作用和共享，与研究界和NIH的透明互动。我们强大的多学科团队继续我们的国家作用和服务的研究界带来的深度和广度，提供机会支持研究人员，并安全地推进体细胞基因组编辑技术人类疾病的新疗法