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Center for Somatic Cell Genome Editing in Nonhuman Primates

非人类灵长类体细胞基因组编辑中心

基本信息

批准号：
10773947
负责人：
DENNIS J. HARTIGAN-O'CONNOR
金额：
$ 134.13万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10773947
关键词：
Acceleration Address Adult Animal Model Animal Testing Animals Benchmarking Biological Biological Assay Biological Models California Center for Translational Science Activities Clinical Sciences Clinical Trials Collaborations Communication Communities Development Disease model Emerging Technologies Ensure Evaluation Feedback Fostering Future Genome Goals Governing Board Human Inflammation Infrastructure Leadership Letters Longevity Methodology Modeling Office of Administrative Management Patients Positioning Attribute Preclinical Testing Primates Procedures Process Productivity Reagent Reporter Research Research Personnel Research Priority Resources Role Safety Schedule Scientist Services Specificity System Techniques Technology Testing Therapeutic Translational Research Translations United States National Institutes of Health Work age group data exchange data sharing empowerment experience fetal gene therapy genome editing home test human disease immunogenicity innovation meetings multidisciplinary new technology nonhuman primate organizational structure outreach pre-clinical research prenatal programs somatic cell gene editing synergism therapeutic genome editing tool

项目摘要

Overall PROJECT SUMMARY / ABSTRACT The Center for Somatic Cell Genome Editing in Nonhuman Primates will fully support studies that will advance the somatic cell genome editing field, and significantly contribute to the future translation of new and emerging technologies for the treatment of human diseases. The Nonhuman Primate Testing Center brings together a robust team of multidisciplinary investigators with partnerships that capitalize on major strengths at UC Davis including the California National Primate Research Center, Genome Center, and Clinical and Translational Science Center. The program will provide unique state-of-the-art capabilities for investigators to conduct high-quality research in nonhuman primates. The Nonhuman Primate Testing Center leverages a supportive framework that has demonstrated a long-standing commitment to outreach and providing collaborative opportunities to investigators nationwide to advance their translational preclinical research goals, including progression to human clinical trials. Through this powerful and proven infrastructure, the Center for Somatic Cell Genome Editing in Nonhuman Primates will address the following Specific Aims: (1) Provide an administrative and organizational structure to advance somatic cell genome editing studies targeting a range of human diseases in all age groups, (2) Partner with investigators to accelerate their translational research objectives, and (3) Ensure synergism and sharing across the small and large animal testing centers and transparent interactions with the research community and the NIH. Our robust multidisciplinary team is poised to continue our national role and service to the research community by bringing the depth and breadth of opportunities available to support investigators, and safely advance somatic cell genome editing technologies to new treatments for human diseases.

总括项目摘要/摘要非人灵长类动物体细胞基因组编辑中心将全力支持将推进体细胞基因组编辑领域，为未来翻译新的和治疗人类疾病的新兴技术。非人灵长类检测中心带来了汇聚一支由多学科调查人员组成的强大团队，并建立合作伙伴关系，利用加州大学戴维斯分校包括加州国家灵长类研究中心、基因组中心和临床与翻译科学中心。该计划将为调查人员提供独特的最先进的能力在非人类灵长类动物中进行高质量的研究。非人灵长类测试中心利用支持性框架，表明了长期致力于外联和提供为全国的研究人员提供合作机会，以推进他们的翻译临床前研究目标，包括人类临床试验的进展。通过这一功能强大且经过验证的基础设施，非人灵长类的体细胞基因组编辑将解决以下具体目标：(1)提供行政和组织结构，以推进针对一系列所有年龄段的人类疾病，(2)与研究人员合作，加快他们的翻译研究目标，以及(3)确保小动物和大动物实验中心和与研究界和美国国立卫生研究院的透明互动。我们强大的多学科团队已做好准备通过为研究社区带来深度和广度，继续我们的国家角色和服务支持研究人员的机会，并安全地推进体细胞基因组编辑技术人类疾病的新疗法。