Center for Somatic Cell Genome Editing in Nonhuman Primates
非人类灵长类体细胞基因组编辑中心
基本信息
- 批准号:10773947
- 负责人:
- 金额:$ 134.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdultAnimal ModelAnimal TestingAnimalsBenchmarkingBiologicalBiological AssayBiological ModelsCaliforniaCenter for Translational Science ActivitiesClinical SciencesClinical TrialsCollaborationsCommunicationCommunitiesDevelopmentDisease modelEmerging TechnologiesEnsureEvaluationFeedbackFosteringFutureGenomeGoalsGoverning BoardHumanInflammationInfrastructureLeadershipLettersLongevityMethodologyModelingOffice of Administrative ManagementPatientsPositioning AttributePreclinical TestingPrimatesProceduresProcessProductivityReagentReporterResearchResearch PersonnelResearch PriorityResourcesRoleSafetyScheduleScientistServicesSpecificitySystemTechniquesTechnologyTestingTherapeuticTranslational ResearchTranslationsUnited States National Institutes of HealthWorkage groupdata exchangedata sharingempowermentexperiencefetalgene therapygenome editinghome testhuman diseaseimmunogenicityinnovationmeetingsmultidisciplinarynew technologynonhuman primateorganizational structureoutreachpre-clinical researchprenatalprogramssomatic cell gene editingsynergismtherapeutic genome editingtool
项目摘要
Overall
PROJECT SUMMARY / ABSTRACT
The Center for Somatic Cell Genome Editing in Nonhuman Primates will fully support studies that will
advance the somatic cell genome editing field, and significantly contribute to the future translation of new and
emerging technologies for the treatment of human diseases. The Nonhuman Primate Testing Center brings
together a robust team of multidisciplinary investigators with partnerships that capitalize on major strengths at
UC Davis including the California National Primate Research Center, Genome Center, and Clinical and
Translational Science Center. The program will provide unique state-of-the-art capabilities for investigators to
conduct high-quality research in nonhuman primates. The Nonhuman Primate Testing Center leverages a
supportive framework that has demonstrated a long-standing commitment to outreach and providing
collaborative opportunities to investigators nationwide to advance their translational preclinical research goals,
including progression to human clinical trials. Through this powerful and proven infrastructure, the Center for
Somatic Cell Genome Editing in Nonhuman Primates will address the following Specific Aims: (1) Provide an
administrative and organizational structure to advance somatic cell genome editing studies targeting a range of
human diseases in all age groups, (2) Partner with investigators to accelerate their translational research
objectives, and (3) Ensure synergism and sharing across the small and large animal testing centers and
transparent interactions with the research community and the NIH. Our robust multidisciplinary team is poised
to continue our national role and service to the research community by bringing the depth and breadth of
opportunities available to support investigators, and safely advance somatic cell genome editing technologies
to new treatments for human diseases.
总括
项目摘要/摘要
非人灵长类动物体细胞基因组编辑中心将全力支持将
推进体细胞基因组编辑领域,为未来翻译新的和
治疗人类疾病的新兴技术。非人灵长类检测中心带来了
汇聚一支由多学科调查人员组成的强大团队,并建立合作伙伴关系,利用
加州大学戴维斯分校包括加州国家灵长类研究中心、基因组中心和临床与
翻译科学中心。该计划将为调查人员提供独特的最先进的能力
在非人类灵长类动物中进行高质量的研究。非人灵长类测试中心利用
支持性框架,表明了长期致力于外联和提供
为全国的研究人员提供合作机会,以推进他们的翻译临床前研究目标,
包括人类临床试验的进展。通过这一功能强大且经过验证的基础设施,
非人灵长类的体细胞基因组编辑将解决以下具体目标:(1)提供
行政和组织结构,以推进针对一系列
所有年龄段的人类疾病,(2)与研究人员合作,加快他们的翻译研究
目标,以及(3)确保小动物和大动物实验中心和
与研究界和美国国立卫生研究院的透明互动。我们强大的多学科团队已做好准备
通过为研究社区带来深度和广度,继续我们的国家角色和服务
支持研究人员的机会,并安全地推进体细胞基因组编辑技术
人类疾病的新疗法。
项目成果
期刊论文数量(0)
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{{ truncateString('DENNIS J. HARTIGAN-O'CONNOR', 18)}}的其他基金
Genetic adjuvants to elicit neutralizing antibodies against HIV
基因佐剂可引发抗艾滋病毒中和抗体
- 批准号:
10491642 - 财政年份:2023
- 资助金额:
$ 134.13万 - 项目类别:
Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools: Antibodies Supplement
非人类灵长类动物体细胞基因组编辑工具评估测试中心:抗体补充剂
- 批准号:
10827650 - 财政年份:2023
- 资助金额:
$ 134.13万 - 项目类别:
Multi-omic understanding of the transformed host T-cell response to HIV following therapeutic vaccination
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10731710 - 财政年份:2023
- 资助金额:
$ 134.13万 - 项目类别:
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10664839 - 财政年份:2022
- 资助金额:
$ 134.13万 - 项目类别:
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