Data Management and Analysis Core
数据管理与分析核心
基本信息
- 批准号:10731712
- 负责人:
- 金额:$ 23.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-22 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffinityAftercareAreaBindingBioinformaticsBiological ProcessBiometryCellular biologyClinicalClinical DataComplexCustomDataData AnalysesData Management ResourcesData ScienceData SetData Storage and RetrievalDimensionsEnsureFlow CytometryGoalsHIVHealthHumanHuman ResourcesImmuneImmune responseInfection ControlInfrastructureIngestionInterruptionJointsKineticsMediatingMetabolicMetadataModalityModelingNatureOnline SystemsOutcomeParticipantPhenotypeProcessRegimenResearchResearch PersonnelResolutionSecureSpecificityStagingStandardizationStatistical Data InterpretationStructureSystemT cell receptor repertoire sequencingT cell responseT-LymphocyteTechniquesTestingVaccine TherapyVaccinesViralViremiaWorkdata harmonizationdata ingestiondata librarydata managementdata modelingdata sharingexperienceimprovedinsightmembermetabolomicsmultidimensional datamultimodal datamultimodalitymultiple omicsnonhuman primatepathogenprogramspublic databaserepositoryshared databasesingle-cell RNA sequencingtherapeutic vaccinetherapy outcometranscriptome sequencingvaccine response
项目摘要
The Data Management and Analysis Core (DSC) will be responsible for performing and supporting
biostatistical analyses and management of multidimensional and subject metadata sets generated in the OmiT-
HIV program. A custom project will be created and maintained on the UCSF Data Library platform to store,
secure, curate, and make accessible all raw and processed biological data and de-identified clinical data
associated with the research program. We will interface with each project team for data ingestion and provide
statistical and bioinformatic support to each. We will additionally perform multi-modal integrative analyses,
including cross-species analysis, to answer questions within and across each project toward better
understanding how vaccine regimens and metabolic conditions influence T-cell responses to and virologic
outcomes of therapeutic vaccination.
We will accomplish these goals with the following specific aims:
Aim 1: Develop and maintain a centralized system of data management and sharing using the UCSF
Data Library.
- We will leverage the UCSF Data Library (UCDL) to facilitate the ingestion, curation, and secure storage
of the diverse high-dimensional data types and metadata or de-identified clinical data generated across
the projects.
- We will apply shared data schemas per modality that store raw and processed data and annotations.
- The UCDL supports web-based data sharing across all members of project and core teams as well as
serves as a staging area for the transfer of all raw and processed data and metadata to ImmPort and
other public databases.
Aim 2: Provide statistical analysis and bioinformatic support for testing project hypotheses relevant to
vaccine regimens, T-cell features, metabolomics, and rebound kinetics.
- We will apply standardized and custom approaches to harmonize datasets for use by all teams.
- We will work collaboratively with each project and core team to perform described analyses including
dimensionality reduction, differential analysis, and association with outcomes.
Aim 3: Integrate multi-modal data to develop a model of joint immune and metabolomic influence over
vaccine responses and control over viremia in ATI.
- We will leverage the complementary nature of these projects and state-of-the-art integrative analysis
techniques, including cross-species analysis, to construct models relating multi-modal factors to
longitudinal immune and virologic outcomes.
- We will address the Bridging Hypotheses described in the Overall component.
数据管理和分析核心(DSC)将负责执行和支持
生物统计分析和管理在OmiT中生成的多维和主题元数据集,
艾滋病项目。将在UCSF数据库平台上创建和维护一个自定义项目,
保护、管理和提供所有原始和处理后的生物数据以及去识别临床数据
与研究项目有关。我们将与每个项目团队进行数据摄取,并提供
统计和生物信息支持。我们还将进行多模态综合分析,
包括跨物种分析,以回答每个项目内部和跨项目的问题,
了解疫苗方案和代谢条件如何影响T细胞应答和病毒学
治疗性疫苗接种的结果。
我们将通过以下具体目标实现这些目标:
目标1:使用UCSF开发和维护数据管理和共享的集中系统
数据库。
- 我们将利用UCSF数据库(UCDL)来促进摄取,策展和安全存储
不同的高维数据类型和元数据或跨
项目。
- 我们将为每种存储原始数据和处理后的数据以及注释的模态应用共享数据模式。
- UCDL支持项目和核心团队的所有成员之间基于Web的数据共享,
作为中转区,将所有原始和处理后的数据和元数据传输到ImmPort,
其他公共数据库。
目标2:提供统计分析和生物信息学支持,以检验与以下方面相关的项目假设:
疫苗方案、T细胞特征、代谢组学和反弹动力学。
- 我们将采用标准化和定制的方法来协调数据集,供所有团队使用。
- 我们将与每个项目和核心团队合作,执行所描述的分析,包括
降维、差分分析以及与结果的关联。
目的3:整合多模态数据,以开发免疫和代谢组学联合影响的模型,
疫苗应答和对ATI中病毒血症的控制。
- 我们将利用这些项目的互补性和最先进的综合分析
技术,包括跨物种分析,以建立模型,
纵向免疫和病毒学结果。
- 我们将讨论总体部分中描述的桥接假设。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('DENNIS J. HARTIGAN-O'CONNOR', 18)}}的其他基金
Genetic adjuvants to elicit neutralizing antibodies against HIV
基因佐剂可引发抗艾滋病毒中和抗体
- 批准号:
10491642 - 财政年份:2023
- 资助金额:
$ 23.54万 - 项目类别:
Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools: Antibodies Supplement
非人类灵长类动物体细胞基因组编辑工具评估测试中心:抗体补充剂
- 批准号:
10827650 - 财政年份:2023
- 资助金额:
$ 23.54万 - 项目类别:
Multi-omic understanding of the transformed host T-cell response to HIV following therapeutic vaccination
治疗性疫苗接种后转化宿主 T 细胞对 HIV 反应的多组学理解
- 批准号:
10731710 - 财政年份:2023
- 资助金额:
$ 23.54万 - 项目类别:
Center for Somatic Cell Genome Editing in Nonhuman Primates
非人类灵长类体细胞基因组编辑中心
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10773947 - 财政年份:2023
- 资助金额:
$ 23.54万 - 项目类别:
CCR5 immunotoxins as components of HIV cure regimens
CCR5 免疫毒素作为 HIV 治疗方案的组成部分
- 批准号:
10664839 - 财政年份:2022
- 资助金额:
$ 23.54万 - 项目类别:
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