The Impact of Hearing Loss Treatment Scale-Up in Persons Aging with HIV on Dementia Risk, Quality of Life, and Healthcare Costs

扩大艾滋病毒感染者听力损失治疗对痴呆风险、生活质量和医疗费用的影响

基本信息

  • 批准号:
    10845892
  • 负责人:
  • 金额:
    $ 27.94万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY When treated with antiretroviral therapy (ART), persons with HIV (PWH) are living life expectancies similar to persons without HIV but remain at increased risk for multimorbidity due to chronic inflammation among other causes. PWH experience a two-fold increase in dementia incidence compared with persons without HIV. Given the absence of treatments to substantially alter the course of dementia, dementia prevention is of critical importance. Recent evidence suggests that hearing loss is a leading preventable cause of dementia and that up to 8% of all dementia worldwide may be due to hearing loss. Hearing loss is common among PWH and occurs up to five years earlier than among persons without HIV. Further, emerging data have shown that hearing aids could substantially mitigate the increased risk of dementia due to hearing loss. Despite the potential for improvements in quality of life and dementia risk, hearing loss treatment uptake among PWH remains low. Only 20% of persons with hearing loss use hearing aids, and PWH may face increased difficulties accessing hearing aid technology given disadvantageous social determinants of health, underinsurance, and other structural barriers to care. Given the high burden of hearing loss and dementia among people aging with HIV, hearing loss screening and treatment may be especially important in this population. In the parent R01 (R01AG069575), Dr. Emily Hyle and her research team detailed methods for developing and populating a simulation model of dementia and multimorbidity for the aging HIV population, the CHARMED (Cognitive impairment, HIV, Aging, heaRt, MEntal health, and Dementia) model. In this administrative supplement, the research team will integrate an existing, validated model of hearing loss natural history and treatment, the Decision model of the Burden of Hearing loss Across the Lifespan (DeciBHAL), with the CHARMED to expand the capacity for multimorbidity modeling. The team will then use the updated CHARMED model to project the effectiveness and cost-effectiveness of hearing loss screening and treatment scale-up among aging PWH. The model will project the potential reduction in dementia risk among aging PWH due to hearing loss screening and treatment. The results of this project will inform future clinical trials, clinical practice, and health policy guidelines for the care of persons aging with HIV.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Emily Parker Hyle其他文献

FORECASTING TRENDS IN CARDIOMETABOLIC RISK FACTORS IN THE UNITED STATES: ESTIMATES BASED ON THE 2020 CENSUS
  • DOI:
    10.1016/s0735-1097(22)02498-6
  • 发表时间:
    2022-03-08
  • 期刊:
  • 影响因子:
  • 作者:
    Reza Mohebi;Chen Chen;Cian P. McCarthy;Hanna Kim Gaggin;Daniel E. Singer;Emily Parker Hyle;Jason H. Wasfy;James L. Januzzi
  • 通讯作者:
    James L. Januzzi
FUTURE OF CARDIOVASCULAR DISEASE IN THE UNITED STATES: ESTIMATES BASED ON THE 2020 CENSUS
  • DOI:
    10.1016/s0735-1097(22)02509-8
  • 发表时间:
    2022-03-08
  • 期刊:
  • 影响因子:
  • 作者:
    Reza Mohebi;Chen Chen;Cian P. McCarthy;Hanna Kim Gaggin;Daniel E. Singer;Emily Parker Hyle;Jason H. Wasfy;James L. Januzzi
  • 通讯作者:
    James L. Januzzi

Emily Parker Hyle的其他文献

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{{ truncateString('Emily Parker Hyle', 18)}}的其他基金

The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
  • 批准号:
    10378711
  • 财政年份:
    2021
  • 资助金额:
    $ 27.94万
  • 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
  • 批准号:
    10613706
  • 财政年份:
    2021
  • 资助金额:
    $ 27.94万
  • 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
  • 批准号:
    10763598
  • 财政年份:
    2021
  • 资助金额:
    $ 27.94万
  • 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
  • 批准号:
    10257768
  • 财政年份:
    2021
  • 资助金额:
    $ 27.94万
  • 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
  • 批准号:
    10790700
  • 财政年份:
    2021
  • 资助金额:
    $ 27.94万
  • 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
  • 批准号:
    10608166
  • 财政年份:
    2021
  • 资助金额:
    $ 27.94万
  • 项目类别:
Cardiovascular Disease in South African HIV Patients: Value of Prevention
南非艾滋病毒患者的心血管疾病:预防的价值
  • 批准号:
    9205462
  • 财政年份:
    2016
  • 资助金额:
    $ 27.94万
  • 项目类别:
Cardiovascular Disease in South African HIV Patients: Value of Prevention
南非艾滋病毒患者的心血管疾病:预防的价值
  • 批准号:
    9064426
  • 财政年份:
    2016
  • 资助金额:
    $ 27.94万
  • 项目类别:

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