The Impact of Hearing Loss Treatment Scale-Up in Persons Aging with HIV on Dementia Risk, Quality of Life, and Healthcare Costs
扩大艾滋病毒感染者听力损失治疗对痴呆风险、生活质量和医疗费用的影响
基本信息
- 批准号:10845892
- 负责人:
- 金额:$ 27.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAdministrative SupplementAdultAffectAgeAgingAlzheimer&aposs disease related dementiaAreaBlindnessCardiovascular DiseasesCaregiversCaringChronicClinicalClinical TrialsCost Effectiveness AnalysisDataDecision ModelingDementiaDevicesDiagnosisDistressEconomicsEducationEffectivenessElderlyEpidemiologyEtiologyFoundationsFrequenciesFutureGeneral PopulationGoalsGuidelinesHIVHealthHealth Care CostsHealth PolicyHealthcareHearingHearing AidsHeartImpaired cognitionIncidenceInflammationInterventionInvestigationKnowledgeLevel of EvidenceLife ExpectancyLinkLongevityMental HealthMentorsMeta-AnalysisMethodsModelingMorbidity - disease rateNational Institute on AgingNatural HistoryObservational StudyParentsPatientsPersonal SatisfactionPersonsPoliciesPolicy MakerPopulationPresbycusisPrevalencePreventionPrevention strategyPublishingQuality of lifeResearchResearch PersonnelRiskRisk ReductionRoleScheduleSeriesTechnologyTestingTimeUpdateage relatedantiretroviral therapybarrier to carecareerclinical effectclinical practicecomorbiditycost effectivecost effectivenessdementia riskeconomic impacteconomic outcomeexperiencehearing impairmenthearing loss riskhearing loss treatmenthearing screeninghigh riskhuman old age (65+)improvedmodels and simulationmortalitymultidisciplinarymultiple chronic conditionsnovelparent grantphysical conditioningprevent hearing lossrandomized, clinical trialsscale upscreeningsocial health determinantssocial integrationsystematic reviewuptake
项目摘要
PROJECT SUMMARY
When treated with antiretroviral therapy (ART), persons with HIV (PWH) are living life expectancies similar to
persons without HIV but remain at increased risk for multimorbidity due to chronic inflammation among other
causes. PWH experience a two-fold increase in dementia incidence compared with persons without HIV. Given
the absence of treatments to substantially alter the course of dementia, dementia prevention is of critical
importance.
Recent evidence suggests that hearing loss is a leading preventable cause of dementia and that up to 8% of
all dementia worldwide may be due to hearing loss. Hearing loss is common among PWH and occurs up to five
years earlier than among persons without HIV. Further, emerging data have shown that hearing aids could
substantially mitigate the increased risk of dementia due to hearing loss. Despite the potential for
improvements in quality of life and dementia risk, hearing loss treatment uptake among PWH remains low.
Only 20% of persons with hearing loss use hearing aids, and PWH may face increased difficulties accessing
hearing aid technology given disadvantageous social determinants of health, underinsurance, and other
structural barriers to care. Given the high burden of hearing loss and dementia among people aging with HIV,
hearing loss screening and treatment may be especially important in this population.
In the parent R01 (R01AG069575), Dr. Emily Hyle and her research team detailed methods for developing and
populating a simulation model of dementia and multimorbidity for the aging HIV population, the CHARMED
(Cognitive impairment, HIV, Aging, heaRt, MEntal health, and Dementia) model. In this administrative
supplement, the research team will integrate an existing, validated model of hearing loss natural history and
treatment, the Decision model of the Burden of Hearing loss Across the Lifespan (DeciBHAL), with the
CHARMED to expand the capacity for multimorbidity modeling. The team will then use the updated CHARMED
model to project the effectiveness and cost-effectiveness of hearing loss screening and treatment scale-up
among aging PWH. The model will project the potential reduction in dementia risk among aging PWH due to
hearing loss screening and treatment. The results of this project will inform future clinical trials, clinical practice,
and health policy guidelines for the care of persons aging with HIV.
项目摘要
当接受抗逆转录病毒疗法(ART)治疗时,艾滋病毒感染者(PWH)的预期寿命与
没有艾滋病毒的人,但由于慢性炎症等原因,
可使.与没有感染艾滋病毒的人相比,威尔斯亲王医院的痴呆症发病率增加了两倍。给定
由于缺乏治疗方法来显著改变痴呆症的病程,因此痴呆症的预防至关重要。
重要性
最近的证据表明,听力损失是痴呆症的主要可预防原因,
全世界所有的痴呆症都可能是由于听力损失。听力损失在威尔士亲王中很常见,最多发生五次
比没有感染艾滋病毒的人早10年。此外,新的数据表明,助听器可以
大大降低了因听力损失而增加的痴呆症风险。尽管有可能
虽然威尔斯亲王医院的生活质素和痴呆症风险有所改善,但接受听力损失治疗的人数仍然偏低。
只有20%的听力损失患者使用助听器,威尔斯亲王医院可能面临更大的困难
助听器技术考虑到健康、保险不足等不利的社会决定因素
护理的结构性障碍。鉴于艾滋病毒感染者中听力损失和痴呆症的高负担,
听力损失筛查和治疗在这一人群中可能特别重要。
在母体R01(R01AG069575)中,艾米丽·海尔博士和她的研究小组详细介绍了开发和
为老龄化的艾滋病毒感染者建立痴呆和多发病的模拟模型,
(认知障碍、HIV、衰老、健康、精神健康和痴呆)模型。本行政
作为补充,研究小组将整合现有的,经过验证的听力损失自然史模型,
听力损失终身负担决策模型(DeciBHAL),
CHARMED扩展了多形态建模的能力。然后,团队将使用更新的CHARMED
预测听力损失筛查和扩大治疗规模的有效性和成本效益的模型
在老年威尔斯亲王医院该模型将预测老年PWH中痴呆风险的潜在降低,
听力损失筛查和治疗。该项目的结果将为未来的临床试验、临床实践,
以及照顾艾滋病毒感染者的卫生政策指导方针。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Emily Parker Hyle其他文献
FORECASTING TRENDS IN CARDIOMETABOLIC RISK FACTORS IN THE UNITED STATES: ESTIMATES BASED ON THE 2020 CENSUS
- DOI:
10.1016/s0735-1097(22)02498-6 - 发表时间:
2022-03-08 - 期刊:
- 影响因子:
- 作者:
Reza Mohebi;Chen Chen;Cian P. McCarthy;Hanna Kim Gaggin;Daniel E. Singer;Emily Parker Hyle;Jason H. Wasfy;James L. Januzzi - 通讯作者:
James L. Januzzi
FUTURE OF CARDIOVASCULAR DISEASE IN THE UNITED STATES: ESTIMATES BASED ON THE 2020 CENSUS
- DOI:
10.1016/s0735-1097(22)02509-8 - 发表时间:
2022-03-08 - 期刊:
- 影响因子:
- 作者:
Reza Mohebi;Chen Chen;Cian P. McCarthy;Hanna Kim Gaggin;Daniel E. Singer;Emily Parker Hyle;Jason H. Wasfy;James L. Januzzi - 通讯作者:
James L. Januzzi
Emily Parker Hyle的其他文献
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{{ truncateString('Emily Parker Hyle', 18)}}的其他基金
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10378711 - 财政年份:2021
- 资助金额:
$ 27.94万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10613706 - 财政年份:2021
- 资助金额:
$ 27.94万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10257768 - 财政年份:2021
- 资助金额:
$ 27.94万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10790700 - 财政年份:2021
- 资助金额:
$ 27.94万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10763598 - 财政年份:2021
- 资助金额:
$ 27.94万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10608166 - 财政年份:2021
- 资助金额:
$ 27.94万 - 项目类别:
Cardiovascular Disease in South African HIV Patients: Value of Prevention
南非艾滋病毒患者的心血管疾病:预防的价值
- 批准号:
9205462 - 财政年份:2016
- 资助金额:
$ 27.94万 - 项目类别:
Cardiovascular Disease in South African HIV Patients: Value of Prevention
南非艾滋病毒患者的心血管疾病:预防的价值
- 批准号:
9064426 - 财政年份:2016
- 资助金额:
$ 27.94万 - 项目类别:
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