The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
基本信息
- 批准号:10608166
- 负责人:
- 金额:$ 68.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAddressAdvocateAgeAge YearsAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmericanAreaCardiovascular DiseasesCaringChronic DiseaseClinicalClinical TrialsCohort StudiesCollaborationsCost AnalysisCost Effectiveness AnalysisCost of IllnessDataDementiaDevelopmentDiagnosisDiseaseDisease OutcomeDisease modelEconomicsEpidemiologyEtiologyEventFunctional disorderFutureGeneral PopulationGoalsGuidelinesHIVHealth Care CostsHeartImpaired cognitionIncidenceIndividualInternationalInterventionLife ExpectancyMajor Depressive DisorderMental DepressionMental HealthMethodsModelingMorbidity - disease rateNational Institute on AgingNeurocognitiveOutcomePatientsPersonsPoliciesPopulationPreventionPrevention strategyPublic HealthQuality of lifeRecording of previous eventsResearchResourcesRiskRisk FactorsStrategic visionStructureTimeTreatment EffectivenessUnited StatesUpdateVulnerable Populationsagedantiretroviral therapycardiovascular disorder preventioncare costsclinical careclinically relevantcohortcomorbiditycostcost effectivecost effectivenesscost outcomesdementia riskdepression modeldesigneconomic outcomeeffective therapyevidence baseexperiencehigh riskimprovedinnovationinterestlife time costmodels and simulationmodifiable riskmortalitymortality riskmultidisciplinarymultiple chronic conditionsnovelpreventsynergism
项目摘要
PROJECT SUMMARY
Almost half of all people diagnosed with HIV in the United States are aged 50 or older, and they are at
increased risk for dementia and multimorbidity. Dementia is of major clinical policy concern because it results
in both inexorable clinical decline and extremely high costs of care. People with HIV are at particularly high risk
because they often have major risk factors for the development of traditional etiologies of dementia, such as
Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD), and they also have a risk of
HIV-associated neurocognitive disease (HAND) despite sustained virologic suppression. Depression,
cardiovascular disease (CVD), and HIV are known to have potent synergies that contribute to the development
of dementia. These comorbidities are modifiable risk factors for dementia that are highly prevalent, known to
be undertreated in people with HIV, and likely to be clinically and economically important targets for prevention
and management.
The overall goal of this proposal is to provide an evidence-based approach for prioritizing and advocating for
interventions to improve the quality of life and reduce morbidity and mortality among people aging with HIV.
The benefits of reducing the burden of depression and CVD among people with HIV may currently be
underestimated, given that concomitant benefits related to multimorbidity are often not captured due to short
durations of observational or trial data. Determining which interventions are most clinically effective and cost-
effective is critically important to understand so that people aging with HIV can benefit from strategies to
reduce their risk of dementia and multimorbidity as they age. We propose to: 1) develop the Cognitive
impairment, HIV, Aging, heaRt, MEntal health, and Dementia (CHARMED) Model, including populating the
model with clinical and outcomes data from the North American AIDS Cohort Collaboration on Research and
Design (NA-ACCORD) and nationally-representative cost data; 2) project clinical and economic outcomes of
people aging with HIV; and 3) perform cost-effectiveness analyses of targeted interventions to reduce the
burden of depression and CVD and to quantify the resultant reduction in dementia and multimorbidity.
This proposal comprises a unique collaboration of experts in methods that are complementary and essential to
complete the research aims: clinical expertise, epidemiology of people aging with HIV, costing, simulation
modeling, and cost-effectiveness analysis. The proposed innovative multimorbidity model will be the first to
include these important comorbidities that are highly prevalent, demonstrate synergies that contribute to
dementia, and are amenable to treatment. The model structure and parameterization can both be revised with
the emergence of updated data and improved understanding of the synergies and pathophysiology. This
simulation modeling approach will allow for analyses of clinical and policy questions that aim to improve clinical
outcomes, improve quality of life, and reduce costs among people aging with HIV.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Emily Parker Hyle其他文献
FORECASTING TRENDS IN CARDIOMETABOLIC RISK FACTORS IN THE UNITED STATES: ESTIMATES BASED ON THE 2020 CENSUS
- DOI:
10.1016/s0735-1097(22)02498-6 - 发表时间:
2022-03-08 - 期刊:
- 影响因子:
- 作者:
Reza Mohebi;Chen Chen;Cian P. McCarthy;Hanna Kim Gaggin;Daniel E. Singer;Emily Parker Hyle;Jason H. Wasfy;James L. Januzzi - 通讯作者:
James L. Januzzi
FUTURE OF CARDIOVASCULAR DISEASE IN THE UNITED STATES: ESTIMATES BASED ON THE 2020 CENSUS
- DOI:
10.1016/s0735-1097(22)02509-8 - 发表时间:
2022-03-08 - 期刊:
- 影响因子:
- 作者:
Reza Mohebi;Chen Chen;Cian P. McCarthy;Hanna Kim Gaggin;Daniel E. Singer;Emily Parker Hyle;Jason H. Wasfy;James L. Januzzi - 通讯作者:
James L. Januzzi
Emily Parker Hyle的其他文献
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{{ truncateString('Emily Parker Hyle', 18)}}的其他基金
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10378711 - 财政年份:2021
- 资助金额:
$ 68.61万 - 项目类别:
The Impact of Hearing Loss Treatment Scale-Up in Persons Aging with HIV on Dementia Risk, Quality of Life, and Healthcare Costs
扩大艾滋病毒感染者听力损失治疗对痴呆风险、生活质量和医疗费用的影响
- 批准号:
10845892 - 财政年份:2021
- 资助金额:
$ 68.61万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10613706 - 财政年份:2021
- 资助金额:
$ 68.61万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10763598 - 财政年份:2021
- 资助金额:
$ 68.61万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10257768 - 财政年份:2021
- 资助金额:
$ 68.61万 - 项目类别:
The CHARMED model: a multimorbidity simulation model for people aging with HIV
CHARMED 模型:针对艾滋病毒老年患者的多发病模拟模型
- 批准号:
10790700 - 财政年份:2021
- 资助金额:
$ 68.61万 - 项目类别:
Cardiovascular Disease in South African HIV Patients: Value of Prevention
南非艾滋病毒患者的心血管疾病:预防的价值
- 批准号:
9205462 - 财政年份:2016
- 资助金额:
$ 68.61万 - 项目类别:
Cardiovascular Disease in South African HIV Patients: Value of Prevention
南非艾滋病毒患者的心血管疾病:预防的价值
- 批准号:
9064426 - 财政年份:2016
- 资助金额:
$ 68.61万 - 项目类别:
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