Role of distinctive cortical motor maps for hand muscles for recovery post stroke

独特的皮质运动图对手部肌肉在中风后恢复中的作用

• 批准号: 10841118
• 负责人: Na Jin Seo
• 金额: $ 6.36万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10841118
• 关键词: African American; African American population; Age; Award; Brain; Communication; Development; Discipline; Doctor of Philosophy; Doctor' s Degree; Engineering; Fostering; Hand; Hand functions; Intervention; Knowledge; Maps; Measures; Motor; Motor Cortex; Muscle; Neuronal Plasticity; Neurosciences; Neurosciences Research; Parents; Population; Recovery; Recovery of Function; Rehabilitation therapy; Reporting; Research; Research Personnel; Role; Science; Stroke; Training Activity; Transcranial magnetic stimulation; Underrepresented Minority; Work; career; grasp; hand rehabilitation; improved; insight; motor control; motor recovery; neural; neurological rehabilitation; neuromuscular; novel; parent grant; post stroke; programs; rehabilitation research; skills; stroke survivor

PROJECT SUMMARY / ABSTRACT The objective of the parent grant (R01 HD094731) is to determine if combining TheraBracelet with hand task practice is superior to hand task practice alone for recovery of hand function post-stroke in an adequately powered study. The parent grant aims to determine the effect of TheraBracelet on hand functional recovery, sensorimotor grip control, and neural communication within the cortical sensorimotor network. The proposed diversity supplement aligns nicely with the scope and approved aims of the parent award as the supplement aims to investigate neuroplasticity toward distinctive cortical motor maps for hand muscles that may contribute to motor recovery. Specifically, the supplement aims to determine the effect of rehabilitation intervention on spatial distinctiveness among motor maps of hand muscles as measured using transcranial magnetic stimulation (TMS) and determine the relationship between motor map changes and motor recovery. This supplement research is expected to inform the new insights for the mechanism for recovery of the fine motor control of the hand following stroke. This new knowledge will be critical for the development of novel rehabilitation treatments that facilitate the cortical neuroplasticity necessary to achieve hand motor recovery. Most importantly, this award will foster the underrepresented minority candidate (Ms. Arianna Alston) for a PhD neuroscience research career. The training activities will focus on developing new research skills for Ms. Alston to perform the supplement research and begin her research career. Specifically, Ms. Alston will (1) enhance her knowledge of neuroscience applied to neurorehabilitation research, (2) develop proficiency in collecting, analyzing, and interpreting TMS motor maps for corticospinal neuromuscular control, and (3) develop a successful application for a PhD program. Therefore, this supplement award will contribute to enhancing diversity in the biomedical workforce, as only 7% of doctoral degree recipients in science and engineering disciplines were African American, whereas African Americans make up 12% of the total US population between the ages of 18-74 according to NSF report.

项目总结/摘要 母公司补助金（R 01 HD 094731）的目的是确定TheraBracelet与手部任务相结合是否 对于中风后手功能的恢复，练习上级优于单独的手任务练习， 动力研究家长资助的目的是确定TheraBracelet在手功能恢复方面的效果， 感觉运动抓握控制和皮层感觉运动网络内的神经通信。拟议 多样性补充与作为补充的母公司奖的范围和批准的目标很好地一致 目的是研究神经可塑性对独特的皮质运动地图的手肌肉，可能有助于 运动恢复具体而言，该补充旨在确定康复干预对 经颅磁刺激测量手部肌肉运动图的空间特异性 (TMS)并确定运动图变化和运动恢复之间的关系。这种补充剂 研究预计将为恢复精细运动控制的机制提供新的见解。 手后中风。这一新的知识将是至关重要的发展新的康复治疗 促进皮质神经可塑性，这是实现手部运动恢复所必需的。最重要的是，这个奖项 将培养代表性不足的少数民族候选人（阿里安娜阿尔斯顿女士）的博士神经科学研究生涯。 培训活动将侧重于为阿尔斯顿女士开发新的研究技能，以进行补充 她开始了自己的研究生涯，并开始研究。具体来说，阿尔斯顿女士将（1）提高她的神经科学知识 应用于神经康复研究，（2）发展收集，分析和解释TMS的熟练程度 运动地图皮质脊髓神经肌肉控制，（3）开发一个成功的应用程序的博士课程。 因此，这一补充奖将有助于提高生物医学劳动力的多样性，因为只有7% 科学和工程学科的博士学位获得者是非洲裔美国人， 根据NSF的报告，美国人占18-74岁美国总人口的12%。