Assessing the commercial potential of high-density electrodes with single unit recording and stimulation capabilities.

评估具有单一单元记录和刺激功能的高密度电极的商业潜力。

• 批准号: 10087359
• 负责人: Ingrid van Welie
• 金额: $ 5.5万
• 依托单位: NEURAL DYNAMICS TECHNOLOGIES INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2021-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10087359
• 关键词: Acute; Amplifiers; Animals; Behavior; Brain; Brain region; Chronic; Custom; Electrodes; Grant; Individual; Innovation Corps; Methods; Microelectrodes; Neurons; Neurosciences Research; Phase; Process; Production; Research Personnel; Rodent; Small Business Innovation Research Grant; System; Technology; United States National Institutes of Health; awake; commercialization; cost; density; design; experimental study; innovation; neural circuit; programs; relating to nervous system

SF424 – Project Summary Understanding how the brain generates certain behaviors requires an understanding of the function of individual neurons in dynamical neural circuits. Currently, there are few technologies available however that allow researchers to record both the activity within a brain region, and between brain regions in the brains of awake, behaving animals. Recent advances in microelectrode fabrication are now enabling recordings of recording hundreds to thousands of neurons simultaneously across brain regions that will lead to functional analyses of dynamical neural circuits. To date however, there are no commercially available low-cost solutions for these kinds of high-density probes. In addition, available high-density probes do not offer customization in design and layout. Neural Dynamics Technologies develops low-cost, highly customizable, high-density probes for acute and chronic experiments in rodents. These probes are innovative because they rely on a new fabrication process that allows for both customization in probe design and low-cost fabrication. Furthermore, our probes are compatible for integration with existing commercial amplifier systems that are standardly used for both acute and chronic experiments in rodents. The first aim of our SBIR proposal was to streamline the design process of high-density probes such that the fabrication process will be ready to produce a wide variety of probe designs at low cost. The second aim involves streamlining the production methods to enable fabrication of customizable probes with broad compatibility with existing commercial amplifier systems. Currently, the above-mentioned aims of our Phase I proposal are largely achieved, and to prepare for commercialization, we would like to participate in the NIH I-Corps program so that we can determine best product-customer fit for our technology.

SF424-项目摘要 要了解大脑是如何产生某些行为的，需要了解 单个神经元在动态神经回路中的功能。目前，几乎没有 然而，现有的技术允许研究人员在 大脑区域，以及清醒的、行为正常的动物的大脑区域之间。近期 微电极制造的进步现在使记录成为可能 成百上千的神经元同时横跨大脑区域，这将导致 动态神经电路的功能分析。然而，到目前为止，没有 针对这类高密度探头的商用低成本解决方案。在……里面 此外，现有的高密度探头在设计和布局方面不提供定制。 神经动力学技术公司开发低成本、高度可定制、高密度 用于啮齿动物急性和慢性实验的探针。这些探头是创新的 因为它们依赖于一种新的制造工艺，该工艺允许在探测器中进行定制 设计和低成本制造。此外，我们的探头兼容集成 现有的商用功放系统标准地用于急性和 在啮齿动物身上进行的长期实验。我们的SBIR建议的第一个目标是简化 高密度探头的设计工艺，以使制造工艺准备好 以低成本生产种类繁多的探头设计。第二个目标涉及精简 能够制造可定制的宽面探头的生产方法 与现有的商用功放系统兼容。 目前，我们第一阶段提案的上述目标基本实现，并且 为了为商业化做准备，我们希望参加美国国立卫生研究院i-Corps计划 这样我们就可以确定最适合我们技术的产品-客户。