3D Printed Configurable and Themoresponsive Intracortical Electrode Array Platform
3D Printed Configurable and Themoresponsive Intracortical Electrode Array Platform
批准号:
10883867
负责人:
HUANAN ZHANG
金额:
$56.6万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
已结题
起止时间:
2023-09-01 至 2024-08-31
关键词:
3D PrintAdhesionsArchitectureBasic ScienceBiochemicalBiocompatible MaterialsBiodegradationBrainCell Culture TechniquesCentral Nervous SystemChronicClinicalCommunicationComputersDataDevelopmentDevice DesignsDevicesDiameterDiseaseElectrodesElectron MicroscopyElectronicsEvaluationForeign BodiesFutureGalliumHistologyImplantImplanted ElectrodesIn VitroIndividualKnowledgeLengthLiquid substanceMass Spectrum AnalysisMetalsMicroelectrodesMotorOutcomeParalysedPatientsPerformancePolymersProcessPropertyResearchResolutionRodent ModelSemiconductorsSensoryShapesSurfaceSystemTechniquesTechnologyTissuesToxic effectUtahWorkbiomaterial compatibilitybrain circuitrybrain computer interfacecarbon fiberdensitydesigndisabilityexperimental studyfabricationimplantable deviceimprovedin vivomanufacturemanufacturing technologymechanical propertiesminimally invasivenervous system disorderneuralneural circuitnext generationnovelpreventresponsetooltwo-photon
中文摘要
项目总结:
英文摘要
PROJECT SUMMARY:
Long-term neural recording using implantable devices has provided important discoveries that have shaped our understanding of how the neural circuitry of the brain works and, more recently, has been used experimentally to treat such disorders as paralysis that provide hope for many suffering from this disability. This promising technology has been challenging to implement reliably over long periods, limiting its use as a chronic basic science tool and threatening its widespread clinical utility. The next-generation implantable devices will need a configurable design and tissue-like material properties. Our project is focused on fundamentally changing the intracortical electrode platform available by integrating two-photon 3D printing technology with thermoresponsive and biostable electrode materials (Gallium-based liquid metal) to design scalable, configurable, and chronically reliable intracortical electrode arrays. The results will provide knowledge that will allow more rapid development of improved and next-generation electrode arrays that work better than what currently exists. The broader impact should inform improved biomedical device design in general and those intended for chronic use in contact with central nervous system tissues.
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会议论文
Gallium Based Mechanically Adaptable Microelectrode Arrays
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批准号:10057878
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项目类别:
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资助金额:$41.94万
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财政年份:2020
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负责人:HUANAN ZHANG
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依托单位:
海外基金