3D Printed Configurable and Themoresponsive Intracortical Electrode Array Platform

3D 打印可配置和热响应皮质内电极阵列平台

• 批准号: 10883867
• 负责人: HUANAN ZHANG
• 金额: $ 56.6万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10883867
• 关键词: 3D Print; Adhesions; Architecture; Basic Science; Biochemical; Biocompatible Materials; Biodegradation; Brain; Cell Culture Techniques; Central Nervous System; Chronic; Clinical; Communication; Computers; Data; Development; Device Designs; Devices; Diameter; Disease; Electrodes; Electron Microscopy; Electronics; Evaluation; Foreign Bodies; Future; Gallium; Histology; Implant; Implanted Electrodes; In Vitro; Individual; Knowledge; Length; Liquid substance; Mass Spectrum Analysis; Metals; Microelectrodes; Motor; Outcome; Paralysed; Patients; Performance; Polymers; Process; Property; Research; Resolution; Rodent Model; Semiconductors; Sensory; Shapes; Surface; System; Techniques; Technology; Tissues; Toxic effect; Utah; Work; biomaterial compatibility; brain circuitry; brain computer interface; carbon fiber; density; design; disability; experimental study; fabrication; implantable device; improved; in vivo; manufacture; manufacturing technology; mechanical properties; minimally invasive; nervous system disorder; neural; neural circuit; next generation; novel; prevent; response; tool; two-photon

PROJECT SUMMARY: Long-term neural recording using implantable devices has provided important discoveries that have shaped our understanding of how the neural circuitry of the brain works and, more recently, has been used experimentally to treat such disorders as paralysis that provide hope for many suffering from this disability. This promising technology has been challenging to implement reliably over long periods, limiting its use as a chronic basic science tool and threatening its widespread clinical utility. The next-generation implantable devices will need a configurable design and tissue-like material properties. Our project is focused on fundamentally changing the intracortical electrode platform available by integrating two-photon 3D printing technology with thermoresponsive and biostable electrode materials (Gallium-based liquid metal) to design scalable, configurable, and chronically reliable intracortical electrode arrays. The results will provide knowledge that will allow more rapid development of improved and next-generation electrode arrays that work better than what currently exists. The broader impact should inform improved biomedical device design in general and those intended for chronic use in contact with central nervous system tissues.

项目总结： 使用可植入设备的长期神经记录提供了重要的发现，这些发现塑造了我们对大脑神经电路如何工作的理解，最近被用于实验治疗瘫痪等疾病，这为许多患有这种残疾的人带来了希望。这项前景看好的技术长期难以可靠实施，限制了其作为一种慢性基础科学工具的使用，并威胁到其广泛的临床应用。下一代可植入设备将需要可配置的设计和类似组织的材料特性。我们的项目致力于从根本上改变皮质内电极平台，将双光子3D打印技术与热敏和生物稳定的电极材料(基于镓的液态金属)相结合，以设计可扩展、可配置和长期可靠的皮质内电极阵列。这些结果将提供知识，使改进和下一代电极阵列能够更快地开发出比现有电极阵列工作得更好的电极阵列。更广泛的影响应该有助于改进总体上的生物医学设备设计，以及那些打算长期使用与中枢神经系统组织接触的设备。