3D Printed Configurable and Themoresponsive Intracortical Electrode Array Platform

3D 打印可配置和热响应皮质内电极阵列平台

• 批准号: 10883867
• 负责人: HUANAN ZHANG
• 金额: $ 56.6万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10883867
• 关键词: 3D Print; Adhesions; Architecture; Basic Science; Biochemical; Biocompatible Materials; Biodegradation; Brain; Cell Culture Techniques; Central Nervous System; Chronic; Clinical; Communication; Computers; Data; Development; Device Designs; Devices; Diameter; Disease; Electrodes; Electron Microscopy; Electronics; Evaluation; Foreign Bodies; Future; Gallium; Histology; Implant; Implanted Electrodes; In Vitro; Individual; Knowledge; Length; Liquid substance; Mass Spectrum Analysis; Metals; Microelectrodes; Motor; Outcome; Paralysed; Patients; Performance; Polymers; Process; Property; Research; Resolution; Rodent Model; Semiconductors; Sensory; Shapes; Surface; System; Techniques; Technology; Tissues; Toxic effect; Utah; Work; biomaterial compatibility; brain circuitry; brain computer interface; carbon fiber; density; design; disability; experimental study; fabrication; implantable device; improved; in vivo; manufacture; manufacturing technology; mechanical properties; minimally invasive; nervous system disorder; neural; neural circuit; next generation; novel; prevent; response; tool; two-photon

PROJECT SUMMARY: Long-term neural recording using implantable devices has provided important discoveries that have shaped our understanding of how the neural circuitry of the brain works and, more recently, has been used experimentally to treat such disorders as paralysis that provide hope for many suffering from this disability. This promising technology has been challenging to implement reliably over long periods, limiting its use as a chronic basic science tool and threatening its widespread clinical utility. The next-generation implantable devices will need a configurable design and tissue-like material properties. Our project is focused on fundamentally changing the intracortical electrode platform available by integrating two-photon 3D printing technology with thermoresponsive and biostable electrode materials (Gallium-based liquid metal) to design scalable, configurable, and chronically reliable intracortical electrode arrays. The results will provide knowledge that will allow more rapid development of improved and next-generation electrode arrays that work better than what currently exists. The broader impact should inform improved biomedical device design in general and those intended for chronic use in contact with central nervous system tissues.

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