Characterizing a transcriptional control region within the Type I interferon gene cluster

表征 I 型干扰素基因簇内的转录控制区域

基本信息

项目摘要

PROJECT SUMMARY Type I interferons (IFN-I) provide the first line of defense against viruses and play a pivotal role in coordinating the innate and adaptive immune responses. The presence of infectious viruses triggers a cascade of events leading to the activation of IFN-I genes that further induce the expression of a large battery of antiviral proteins. This antiviral program is something that must be selectively induced only when appropriate as chronic signaling is associated with severe inflammatory phenotypes and autoimmunity. These so called ‘interferonopathies’ are a clinically heterogenic group of diseases that are becoming increasingly recognized and speak to the importance of silencing the IFN-I locus in the absence of infection. Here we propose to define how a conserved gene called Kelch-Like Family Member 9 (KLHL9), which is found in the center of the IFN-I gene cluster, ensures the transcriptional repression of the region in the absence of virus infection. This proposed research will advance the understanding of how the IFN system functions at the center of immune and inflammatory diseases, and should also lead to a better understanding as to the molecular cause of at least a subset of interferonopathies.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)

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Benjamin R. tenOever其他文献

RNA viruses and the host microRNA machinery
RNA 病毒与宿主微小 RNA 机制
  • DOI:
    10.1038/nrmicro2971
  • 发表时间:
    2013-02-15
  • 期刊:
  • 影响因子:
    103.300
  • 作者:
    Benjamin R. tenOever
  • 通讯作者:
    Benjamin R. tenOever

Benjamin R. tenOever的其他文献

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{{ truncateString('Benjamin R. tenOever', 18)}}的其他基金

Defining the Biology of the ADAR1-RISC Complex
定义 ADAR1-RISC 复合体的生物学
  • 批准号:
    10879449
  • 财政年份:
    2022
  • 资助金额:
    $ 21.19万
  • 项目类别:
Defining the Biology of the ADAR1-RISC Complex
定义 ADAR1-RISC 复合体的生物学
  • 批准号:
    10494390
  • 财政年份:
    2022
  • 资助金额:
    $ 21.19万
  • 项目类别:
Characterizing a transcriptional control region within the Type I interferon gene cluster
表征 I 型干扰素基因簇内的转录控制区域
  • 批准号:
    10506860
  • 财政年份:
    2022
  • 资助金额:
    $ 21.19万
  • 项目类别:
Defining the Biology of the ADAR1-RISC Complex
定义 ADAR1-RISC 复合体的生物学
  • 批准号:
    10631184
  • 财政年份:
    2022
  • 资助金额:
    $ 21.19万
  • 项目类别:
Small viral RNAs as determinants of influenza A virus pathogenesis
小病毒 RNA 作为甲型流感病毒发病机制的决定因素
  • 批准号:
    10557136
  • 财政年份:
    2020
  • 资助金额:
    $ 21.19万
  • 项目类别:
Small viral RNAs as determinants of influenza A virus pathogenesis
小病毒 RNA 作为甲型流感病毒发病机制的决定因素
  • 批准号:
    10524881
  • 财政年份:
    2020
  • 资助金额:
    $ 21.19万
  • 项目类别:
Small viral RNAs as determinants of influenza A virus pathogenesis
小病毒 RNA 作为甲型流感病毒发病机制的决定因素
  • 批准号:
    10097984
  • 财政年份:
    2020
  • 资助金额:
    $ 21.19万
  • 项目类别:
Stemness and the cellular response to virus infection
干性和细胞对病毒感染的反应
  • 批准号:
    9528170
  • 财政年份:
    2018
  • 资助金额:
    $ 21.19万
  • 项目类别:
The biology of the nuclear export protein in influenza A virus replication
甲型流感病毒复制中核输出蛋白的生物学
  • 批准号:
    9975684
  • 财政年份:
    2017
  • 资助金额:
    $ 21.19万
  • 项目类别:
The mammalian small RNA machinery and its role in antiviral defenses
哺乳动物小RNA机制及其在抗病毒防御中的作用
  • 批准号:
    8967559
  • 财政年份:
    2014
  • 资助金额:
    $ 21.19万
  • 项目类别:

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