Using genetically informed designs to understand the impact of parental divorce/separation and parental marital discord on offspring alcohol outcomes

使用遗传信息设计来了解父母离婚/分居和父母婚姻不和对后代酗酒结果的影响

• 批准号: 10884635
• 负责人: JESSICA E SALVATORE
• 金额: $ 31.73万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10884635
• 关键词: Address; Adult; Adverse effects; African American; Age; Alcohol abuse; Alcohol consumption; Alcohols; American; Behavior; Birth Records; Clinical; Complex; Data; Data Set; Diagnostic; Distress; Divorce; Environment; Etiology; European; European ancestry; Exposure to; Family; Female; Funding; Genes; Genetic; Genetic Predisposition to Disease; Genetic Risk; Genetic study; Goals; Heritability; Individual; Inherited; Intervention; Interview; Joints; Methods; Mission; Modeling; Molecular Genetics; Nature; Onset of illness; Outcome; Parents; Participant; Pathogenicity; Pathway interactions; Population; Predictive Factor; Public Health; Recording of previous events; Research; Research Personnel; Risk; Role; Sampling; Skin; Stress; Substance Use Disorder; Testing; Twin Multiple Birth; Twin Studies; United States National Institutes of Health; Virginia; Work; alcohol misuse; alcohol misuse prevention; alcohol related problem; alcohol use disorder; archived data; childhood adversity; cost; design; divorce/separation; environmental stressor; ethnic diversity; experience; gene environment interaction; genetics of alcoholism; high risk; intergenerational; intervention program; novel; offspring; population based; proband; programs; psychoeducation; psychoeducational; psychoeducational intervention; recruit; response; social influence; stressor; tool; transmission process

Project Summary The objective in this proposal is to advance the understanding of the mechanisms through which parental divorce/separation and marital discord influence offspring alcohol use disorder (AUD) and related outcomes (e.g., earlier age at first drink and alcohol misuse). It is commonly thought that parental divorce/separation and parental marital discord have direct, pathogenic effects on offspring alcohol outcomes. Yet, there is a limited appreciation of the role of genetic factors in these associations, despite suggestive evidence that offspring exposed to parental marital problems also inherit AUD genetic predispositions, and that AUD genetic predispositions can sensitize individuals to the adverse effects of environmental stressors. This underscores the need to study the confluence of genetic factors and these common family adversities to understand their joint legacy on offspring alcohol outcomes. The goal here is to address this gap using data from two intergenerational, genetically-informative studies. The first is the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, a sample of European ancestry twins (N=9345, 45% female) recruited from birth records for whom direct psychiatric interview data were collected on all twins plus a subset of parents (N=1472, 58% female), with additional parental data collected via diagnostic psychiatric family history interviews with the twins. The second is the Collaborative Study on the Genetics of Alcoholism (N=11561, 53% female), a molecular genetic study of an ethnically diverse (69% European American, 31% African American) sample of families primarily recruited via treatment-seeking probands for whom psychiatric interview data were collected from all participants. These two samples are mutually informative in permitting examination of the generalizability and convergence of findings across different methods and populations. Guided by a bio- ecological framework, the aims are to: (1) examine the extent to which associations between parental divorce/separation, parental marital discord, and offspring alcohol outcomes reflect direct (i.e., ‘causal’) effects versus shared genetic effects; and (2) examine whether offspring genetic factors predict variability in their responses to parental divorce/separation and parental marital discord. The results may have theoretical implications for the indirect, environmental pathways through which genetic risk for alcohol problems is transmitted in families (i.e., gene-environment correlation), as well as an understanding of how genetic influences confer sensitivity to familial stressors (i.e., gene-environment interaction). In turn, the results may inform clinicians’ psychoeducation efforts to prevent alcohol misuse among offspring from families experiencing marital distress and divorce. More broadly, this work will contribute to the long-term goal of the Early Stage Investigator PI’s program of research to delineate how genetic factors and close relationship factors come together to influence the onset, persistence, and discontinuity of alcohol misuse.

项目总结

项目成果

A Prospective Study of Mental Health, Well-Being, and Substance Use During the Initial COVID-19 Pandemic Surge.

• DOI: 10.1177/21677026211013499
• 发表时间: 2021-06-02
• 期刊: Clinical psychological science : a journal of the Association for Psychological Science
• 作者: Haydon KC;Salvatore JE
• 通讯作者: Salvatore JE

Relationship perceptions and conflict behavior among cannabis users.

大麻使用者之间的关系认知和冲突行为。

• DOI: 10.1016/j.drugalcdep.2022.109502
• 发表时间: 2022
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Haydon,KatherineC;Salvatore,JessicaE
• 通讯作者: Salvatore,JessicaE

Role of parental divorce and discord in the intergenerational transmission of alcohol use disorder.

• DOI: 10.1016/j.drugalcdep.2022.109404
• 发表时间: 2022-05-01
• 期刊: DRUG AND ALCOHOL DEPENDENCE
• 影响因子: 4.2
• 作者: Salvatore, Jessica E.;Aggen, Steven H.;Kendler, Kenneth S.
• 通讯作者: Kendler, Kenneth S.