Administrative Core

行政核心

• 批准号: 10848509
• 负责人: BARBARA J MASON
• 金额: $ 10万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-20 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10848509
• 关键词: Abstinence; Advisory Committees; Alcoholism; Alcohols; Amygdaloid structure; Animal Model; Attention; Behavioral; Biochemical; Biological Assay; Budgets; Cells; Cellular Neurobiology; Charge; Collaborations; Communities; Community Outreach; Data; Dependence; Ensure; Expenditure; Faculty; Familiarity; Fostering; Funding; Future; Goals; Grant; Guidelines; Health Personnel; Healthcare; Heavy Drinking; Internships; Lead; Leadership; Maps; Medial; Methods; Molecular; Monitor; Neurobiology; Neuroimmune; Neuropharmacology; Neurosciences; Outcome; Postdoctoral Fellow; Preclinical Testing; Procedures; Proteomics; Publications; Recommendation; Relapse; Research; Research Institute; Research Personnel; Resources; Review Committee; Role; Science; Scientist; Series; Services; Standardization; Stress; Techniques; Underrepresented Minority; United States National Institutes of Health; Youth; alcohol effect; alcohol research; alcohol use disorder; archived data; cost effective; data archive; equity, diversity, and inclusion; experience; health disparity; high risk; interest; lecturer; meetings; neural circuit; neurophysiology; neuroproteomics; next generation; operation; outreach; posters; programs; social media; success; vapor; web site

Abstract Administrative Core The Administrative Core of The Scripps Research Institute-Alcohol Research Center (TSRI-ARC) provides leadership and an organizational framework to meet the Center’s Specific Aims. Center-wide scientific aims in the renewal are focused on the cellular and molecular mechanisms that modulate top-down medial prefrontal control of the central amygdala and underlie stress-induced vulnerability to relapse and excessive drinking during protracted abstinence. The Administrative Core facilitates Center-wide direction, oversight, and integration across 5 Research Components (Functional Connectomics, Neuropharmacology, Molecular, Neurophysiology, and Neurocircuitry), and 3 Cores (Dissemination, Animal Models, and Neuroproteomics). Specific Aims are: (1) Provide scientific and administrative leadership for TSRI-ARC Cores and Research Components to function in an optimal and synergistic manner. The Center Director chairs monthly meetings of the Steering Committee which is comprised of all Project Leads, and with the help of the Scientific Director and Deputy Scientific Director, monitors progress and outcomes of all projects, develops new collaborations, and identifies problems and proposes fair solutions. A Program Advisory Committee comprised of five external experts in domains relevant to TSRI-ARC will meet annually to review progress and make recommendations to the Director. The Director implements course corrections and the reprioritization of resources when indicated, and dynamically manages expenditures to bolster TSRI-ARC aims. (2) Facilitate the dissemination of expertise between Cores and Research Components and the utilization of Core resources. Cores provide systematic prioritization of resources and standardized methods that foster integration of projects. Rapid dissemination and utilization of Core expertise (e.g., new animal models, biochemical analyses, single-cell proteomics analysis techniques, and functional neurocircuitry mapping techniques) are accomplished by monthly Steering Committee meetings and monthly Center-at-Large scientific seminars. Requests for Core services are submitted (and data archived) on the TSRI-ARC website, providing transparency of Core operations and facilitating ongoing review of the Cores’ efficiency by the Steering Committee. (3) Provide scientific enrichment for TSRI-ARC and disseminate TSRI-ARC research. The Administrative Core will organize monthly scientific seminars to stimulate collaborations and scientific enrichment throughout the Center-at-Large. Seminars include a presentation by a project Lead on recent progress, or an invited lecturer on research relevant to TSRI-ARC’s scientific interests, in tandem with 1:1 meetings with investigators. TSRI-ARC will host an annual Scientific Retreat on the TSRI campus, consisting of a poster session, a data blitz, and presentations by TSRI-ARC and Center-at-Large investigators, T32 postdoctoral trainees, and interns. TSRI-ARC discoveries are shared with scientific, healthcare and lay stakeholders via scientific publications and presentations, our website and social media, and outreach to youth from health disparities backgrounds who are at higher risk for stress and AUD.

抽象行政核心 斯克里普斯研究所酒精研究中心（TSRI-ARC）的行政核心提供 领导和组织框架，以满足该中心的具体目标。中心范围内的科学目标， 更新的重点是调节自上而下的内侧前额叶的细胞和分子机制 中央杏仁核的控制和基础的压力诱导的脆弱性，复发和过度饮酒， 长期禁欲行政核心促进全中心的指导、监督和整合 跨5个研究组成部分（功能性连接组学，神经药理学，分子，神经生理学， 和神经电路），和3个核心（传播，动物模型和神经蛋白质组学）。具体目标是：（1） 为TSRI-ARC核心和研究组件提供科学和行政领导， 以最佳和协同的方式发挥作用。中心主任主持指导委员会每月会议 委员会由所有项目负责人组成，并在科学主任和副主任的帮助下， 科学总监，监测所有项目的进展和成果，开发新的合作，并确定 问题，并提出合理的解决方案。由五名外部专家组成的计划咨询委员会， 与TSRI-ARC相关的领域将每年举行一次会议，审查进展情况，并向主任提出建议。 司长在有指示时，动态地纠正方向，重新安排资源的优先次序。 管理支出，以支持TSRI-ARC的目标。(2)促进在下列机构之间传播专门知识： 核心和研究组件以及核心资源的利用。核心提供系统化 资源的优先次序和促进项目一体化的标准化方法。快速传播和 利用核心专业知识（例如，新的动物模型，生化分析，单细胞蛋白质组学分析 技术和功能性神经回路映射技术）由每月指导委员会完成 会议和每月的大型科学研讨会。提交核心服务请求（和数据 存档）在TSRI-ARC网站上，提供核心业务的透明度并促进持续审查 指导委员会对核心的效率进行评估。(3)为TSRI-ARC提供科学丰富， 传播TSRI-ARC研究。行政核心将每月组织科学研讨会， 促进整个中心的合作和科学丰富。研讨会包括 由项目负责人介绍最新进展，或邀请讲师介绍与TSRI-ARC相关的研究 科学兴趣，并与研究人员进行1：1的会议。TSRI-ARC将举办年度科学 在TSRI校园静修，包括海报会议，数据闪电战，以及TSRI-ARC和 中心在-大调查员，T32博士后学员，和实习生。TSRI-ARC的发现与 通过科学出版物和演示文稿，我们的网站和社交媒体， 媒体，以及对来自健康差异背景的年轻人进行宣传，这些年轻人面临更高的压力和AUD风险。